scholarly journals ERP evidence of preserved early memory function in term infants with neonatal encephalopathy following therapeutic hypothermia

2016 ◽  
Vol 80 (6) ◽  
pp. 800-808 ◽  
Author(s):  
Katie M. Pfister ◽  
Lei Zhang ◽  
Neely C. Miller ◽  
Solveig Hultgren ◽  
Chris J. Boys ◽  
...  
Keyword(s):  
Therapeutic Hypothermia ◽  
Memory Function ◽  
Neonatal Encephalopathy ◽  
Term Infants ◽  
Early Memory

Is there a role for therapeutic hypothermia administration in term infants with mild neonatal encephalopathy?

2019 ◽  
Vol 40 (3) ◽  
pp. 522-529 ◽  
Author(s):  
Laura Perretta ◽  
Rachel Reed ◽  
Gail Ross ◽  
Jeffrey Perlman
Keyword(s):  
Therapeutic Hypothermia ◽  
Neonatal Encephalopathy ◽  
Term Infants

scholarly journals Mammillary body atrophy and other MRI correlates of school-age outcome following neonatal hypoxic-ischemic encephalopathy

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Kim V. Annink ◽  
Linda S. de Vries ◽  
Floris Groenendaal ◽  
Rian M. J. C. Eijsermans ◽  
Manouk Mocking ◽  
...  
Keyword(s):  
Therapeutic Hypothermia ◽  
Memory Function ◽  
Neurodevelopmental Outcome ◽  
Standard Of Care ◽  
Hypoxic Ischemic Encephalopathy ◽  
School Age ◽  
Brain Volumes ◽  
Mammillary Bodies ◽  
Memory Problems ◽  
Ischemic Encephalopathy

AbstractThe mammillary bodies (MB) and hippocampi are important for memory function and are often affected following neonatal hypoxic ischemic encephalopathy (HIE). The aim of this study was to assess neurodevelopmental outcome in 10-year-old children with HIE with and without therapeutic hypothermia. Additional aims were to assess the associations between MB atrophy, brain volumes (including the hippocampi), white matter microstructure and neurodevelopmental outcome at school-age. Ten-year-old children with HIE were included, who were treated with therapeutic hypothermia (n = 22) or would have qualified but were born before this became standard of care (n = 28). Children completed a neuropsychological and motor assessment and MRI. Mammillary bodies were scored as normal or atrophic at 10 years. Brain volumes were segmented on childhood MRI and DTI scans were analysed using tract-based spatial statistics. Children with HIE suffered from neurocognitive and memory problems at school-age, irrespective of hypothermia. Hippocampal volumes and MB atrophy were associated with total and performance IQ, processing speed and episodic memory in both groups. Normal MB and larger hippocampi were positively associated with global fractional anisotropy. In conclusion, injury to the MB and hippocampi was associated with neurocognition and memory at school-age in HIE and might be an early biomarker for neurocognitive and memory problems.

scholarly journals Erythropoietin monotherapy for neuroprotection after neonatal encephalopathy in low-to-middle income countries: a systematic review and meta-analysis

2021 ◽  
Author(s):  
Phoebe Ivain ◽  
Paolo Montaldo ◽  
Aamir Khan ◽  
Ramyia Elagovan ◽  
Constance Burgod ◽  
...  
Keyword(s):  
Meta Analysis ◽  
Neonatal Encephalopathy ◽  
Neurodevelopmental Outcomes ◽  
Term Infants ◽  
Middle Income ◽  
Middle Income Countries ◽  
Pooled Data ◽  
Risk Of Death ◽  
Low Middle Income Countries ◽  
Near Term

Abstract Objective We examined whether erythropoietin monotherapy improves neurodevelopmental outcomes in near-term and term infants with neonatal encephalopathy (NE) in low-middle income countries (LMICs). Methods We searched Pubmed, Embase, and Web of Science databases to identify studies that used erythropoietin (1500–12,500 units/kg/dose) or a derivative to treat NE. Results Five studies, with a total of 348 infants in LMICs, were retrieved. However, only three of the five studies met the primary outcome of death or neuro-disability at 18 months of age or later. Erythropoietin reduced the risk of death (during the neonatal period and at follow-up) or neuro-disability at 18 months or later (p < 0.05). Death or neuro-disability occurred in 27.6% of the erythropoietin group and 49.7% of the comparison group (risk ratio 0.56 (95% CI: 0.42–0.75)). Conclusion The pooled data suggest that erythropoietin monotherapy may improve outcomes after NE in LMICs where therapeutic hypothermia is not available.

Management of Comfort and Sedation in Neonates with Neonatal Encephalopathy Treated with Therapeutic Hypothermia

2021 ◽  
pp. 101264
Author(s):  
Christopher McPherson ◽  
Adam Frymoyer ◽  
Cynthia M. Ortinau ◽  
Steven P. Miller ◽  
Floris Groenendaal
Keyword(s):  
Therapeutic Hypothermia ◽  
Neonatal Encephalopathy

Chorioamnionitis and Neonatal Encephalopathy in Term Infants With Fetal Acidemia: Histopathologic Correlations

2005 ◽  
Vol 33 (3) ◽  
pp. 162-165 ◽  
Author(s):  
Lina Shalak ◽  
Sarah Johnson-Welch ◽  
Jeffrey M. Perlman
Keyword(s):  
Neonatal Encephalopathy ◽  
Term Infants

scholarly journals Cost-Effectiveness of Therapeutic Hypothermia to Treat Neonatal Encephalopathy

2010 ◽  
Vol 13 (6) ◽  
pp. 695-702 ◽  
Author(s):  
Dean A. Regier ◽  
Stavros Petrou ◽  
Jane Henderson ◽  
Oya Eddama ◽  
Nishma Patel ◽  
...  
Keyword(s):  
Cost Effectiveness ◽  
Therapeutic Hypothermia ◽  
Neonatal Encephalopathy
Sign in / Sign up

Export Citation Format

Share Document