Acute sleep deprivation upregulates serotonin 2A receptors in the frontal cortex of mice via the immediate early gene Egr3

2022 ◽  
Author(s):  
Xiuli Zhao ◽  
Annika B. Ozols ◽  
Kimberly T. Meyers ◽  
Janet Campbell ◽  
Andrew McBride ◽  
...  
Keyword(s):  
Sleep Deprivation ◽  
Frontal Cortex ◽  
Immediate Early Gene ◽  
Early Gene ◽  
Immediate Early ◽  
Acute Sleep Deprivation ◽  
Serotonin 2A

scholarly journals Sleep deprivation rapidly upregulates serotonin 2A receptor expression via the immediate early gene Egr3

2019 ◽  
Author(s):  
X. Zhao ◽  
K. T. Meyers ◽  
A. McBride ◽  
K. K. Marballi ◽  
A. M. Maple ◽  
...  
Keyword(s):  
Sleep Deprivation ◽  
Immediate Early Gene ◽  
Receptor Expression ◽  
Early Gene ◽  
Immediate Early ◽  
Early Growth Response ◽  
Brain Receptor ◽  
Serotonin 2A

AbstractSerotonin 2A receptors (5-HT2ARs) mediate the effects of hallucinogenic drugs and antipsychotic medications, and are reduced in schizophrenia patients’ brains. However, the mechanisms that regulate 5-HT2AR expression remain poorly understood. We show that an environmental stimulus, sleep deprivation, upregulates 5-HT2ARs in the mouse frontal cortex (FC) in just 6-8 hours. This induction requires the immediate early gene transcription factor early growth response 3 (Egr3). Further, EGR3 binds to the Htr2a promoter in the FC in vivo, and drives reporter construct expression in vitro via two Htr2a promoter binding sites. These findings suggest that EGR3 directly regulates FC Htr2a expression in response to physiologic stimuli, providing a mechanism by which environment rapidly alters levels of a brain receptor that mediates symptoms, and treatment, of mental illness.One Sentence SummaryJust 6-8 hours of sleep deprivation upregulates brain levels of the receptor that mediates the response to hallucinogens.

scholarly journals Immediate Early Gene Expression in Brain During Sleep Deprivation: Preliminary Observations

SLEEP ◽  
1993 ◽  
Vol 16 (1) ◽  
pp. 1-7 ◽  
Author(s):  
Bruce F. O'Hara ◽  
Kimberly A. Young ◽  
Fiona L. Watson ◽  
H. Craig Heller ◽  
Thomas S. Kilduff
Keyword(s):  
Gene Expression ◽  
Sleep Deprivation ◽  
Immediate Early Gene ◽  
Early Gene ◽  
Immediate Early ◽  
Early Gene Expression

Phylogenetic relatedness and immediate early gene expression in black-capped chickadees

2012 ◽  
Author(s):  
Christopher B. Sturdy ◽  
Marc T. Avey ◽  
Laurie L. Bloomfield ◽  
Julie E. Elie ◽  
Todd M. Freeberg ◽  
...  
Keyword(s):  
Gene Expression ◽  
Immediate Early Gene ◽  
Early Gene ◽  
Immediate Early ◽  
Phylogenetic Relatedness ◽  
Early Gene Expression

scholarly journals Role of oxidative stress in intermittent hypoxia-induced immediate early gene activation in rat PC12 cells

2004 ◽  
Vol 557 (3) ◽  
pp. 773-783 ◽  
Author(s):  
Guoxiang Yuan ◽  
Gautam Adhikary ◽  
Andrew A. McCormick ◽  
John. J. Holcroft ◽  
Ganesh K. Kumar ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Pc12 Cells ◽  
Intermittent Hypoxia ◽  
Gene Activation ◽  
Immediate Early Gene ◽  
Early Gene ◽  
Immediate Early
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