scholarly journals Acute cognitive effects of single-dose intravenous ketamine in major depressive and posttraumatic stress disorder

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Margaret T. Davis ◽  
Nicole DellaGiogia ◽  
Paul Maruff ◽  
Robert H. Pietrzak ◽  
Irina Esterlis
Keyword(s):  
Posttraumatic Stress Disorder ◽  
Single Dose ◽  
Cognitive Function ◽  
Posttraumatic Stress ◽  
Verbal Memory ◽  
Stress Disorder ◽  
Cognitive Measures ◽  
Major Depressive ◽  
Cognitive Domains ◽  
Magnitude Improvement

AbstractIntravenous (IV) subanesthetic doses of ketamine have been shown to reduce psychiatric distress in both major depressive (MDD) and posttraumatic stress disorder (PTSD). However, the effect of ketamine on cognitive function in these disorders is not well understood. To address this gap, we examined the effect of a single dose of IV ketamine on cognition in individuals with MDD and/or PTSD relative to healthy controls (HC). Psychiatric (n = 29; 15 PTSD, 14 MDD) and sex- age- and IQ matched HC (n = 29) groups were recruited from the community. A single subanesthetic dose of IV ketamine was administered. Mood and cognitive measures were collected prior to, 2 h and 1 day post-ketamine administration. MDD/PTSD individuals evidenced a large-magnitude improvement in severity of depressive symptoms at both 2-hours and 1 day post-ketamine administration (p’s < .001, Cohen d’s = 0.80–1.02). Controlling for baseline performance and years of education, IV ketamine induced declines in attention (ATTN), executive function (EF), and verbal memory (VM) 2 h post-administration, all of which had resolved by 1 day post-ketamine across groups. The magnitude of cognitive decline was significantly larger in MDD/PTSD relative to HC on attention only (p = .012, d = 0.56). Ketamine did not affect working memory (WM) performance. Cognitive function (baseline, change from baseline to post-ketamine) was not associated with antidepressant response to ketamine. Results suggest that while ketamine may have an acute deleterious effect on some cognitive domains in both MDD/PTSD and HC individuals, most notably attention, this reduction is transient and there is no evidence of ketamine-related cognitive dysfunction at 1 day post-administration.

Learning and Consolidation of Verbal Declarative Memory in Patients with Posttraumatic Stress Disorder

2010 ◽  
Vol 218 (2) ◽  
pp. 135-140 ◽  
Author(s):  
Slawomira J. Diener ◽  
Herta Flor ◽  
Michèle Wessa
Keyword(s):  
Posttraumatic Stress Disorder ◽  
Posttraumatic Stress ◽  
Verbal Memory ◽  
Stress Disorder ◽  
Declarative Memory ◽  
Memory Performance ◽  
Verbal Learning ◽  
Depression Scale ◽  
Learning Performance ◽  
Ptsd Symptoms

Impairments in declarative memory have been reported in posttraumatic stress disorder (PTSD). Fragmentation of explicit trauma-related memory has been assumed to impede the formation of a coherent memorization of the traumatic event and the integration into autobiographic memory. Together with a strong non-declarative memory that connects trauma reminders with a fear response the impairment in declarative memory is thought to be involved in the maintenance of PTSD symptoms. Fourteen PTSD patients, 14 traumatized subjects without PTSD, and 13 non-traumatized healthy controls (HC) were tested with the California Verbal Learning Test (CVLT) to assess verbal declarative memory. PTSD symptoms were assessed with the Clinician Administered PTSD Scale and depression with the Center of Epidemiological Studies Depression Scale. Several indices of the CVLT pointed to an impairment in declarative memory performance in PTSD, but not in traumatized persons without PTSD or HC. No group differences were observed if recall of memory after a time delay was set in relation to initial learning performance. In the PTSD group verbal memory performance correlated significantly with hyperarousal symptoms, after concentration difficulties were accounted for. The present study confirmed previous reports of declarative verbal memory deficits in PTSD. Extending previous results, we propose that learning rather than memory consolidation is impaired in PTSD patients. Furthermore, arousal symptoms may interfere with successful memory formation in PTSD.

Verbal Memory Deficits in Children With Posttraumatic Stress Disorder

2008 ◽  
Author(s):  
Karen Lau ◽  
Casey Hoffman ◽  
Christiane Burnett ◽  
Kristin Samuelson
Keyword(s):  
Posttraumatic Stress Disorder ◽  
Posttraumatic Stress ◽  
Verbal Memory ◽  
Stress Disorder ◽  
Memory Deficits

scholarly journals Hemicrania Continua Headache in a Veteran with Posttraumatic Stress Disorder and Major Depressive Disorder without Traumatic Brain Injury

2012 ◽  
Vol 2012 ◽  
pp. 1-3
Author(s):  
Brandon A. Kohrt ◽  
Erica Duncan
Keyword(s):  
Posttraumatic Stress Disorder ◽  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Posttraumatic Stress ◽  
Stress Disorder ◽  
Psychiatric Symptoms ◽  
Hemicrania Continua ◽  
Major Depressive ◽  
High Flow Oxygen ◽  
Psychopharmacological Intervention

Hemicrania continua is a headache characterized by chronic unremitting unilateral pain associated with ipsilateral autonomic findings. This type of headache responds to high-flow oxygen and indomethacin. This case report describes a male veteran with posttraumatic stress disorder (PTSD) and major depressive disorder who suffers from comorbid hemicrania continua. The psychiatric symptoms were recalcitrant to psychopharmacological intervention. However, when the patient's hemicrania continua was treated appropriately, the patient's psychiatric symptoms also abated. This case demonstrates the need to address physical comorbidities that may exacerbate psychiatric disorders, such as PTSD.

Cognitive function in Japanese women with posttraumatic stress disorder: Association with exercise habits

2018 ◽  
Vol 236 ◽  
pp. 306-312 ◽  
Author(s):  
Ryoko Narita-Ohtaki ◽  
Hiroaki Hori ◽  
Mariko Itoh ◽  
Mingming Lin ◽  
Madoka Niwa ◽  
...  
Keyword(s):  
Posttraumatic Stress Disorder ◽  
Cognitive Function ◽  
Posttraumatic Stress ◽  
Stress Disorder ◽  
Japanese Women ◽  
Exercise Habits

scholarly journals Posttraumatic stress disorder: a serious post-earthquake complication

2017 ◽  
Vol 39 (2) ◽  
pp. 135-143 ◽  
Author(s):  
Mudassir Farooqui ◽  
Syed A. Quadri ◽  
Sajid S. Suriya ◽  
Muhammad Adnan Khan ◽  
Muhammad Ovais ◽  
...  
Keyword(s):  
Posttraumatic Stress Disorder ◽  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Posttraumatic Stress ◽  
Stress Disorder ◽  
Psychological Symptoms ◽  
Relevant Information ◽  
Health Condition ◽  
Major Depressive ◽  
Compulsive Disorder

Abstract Objectives Earthquakes are unpredictable and devastating natural disasters. They can cause massive destruction and loss of life and survivors may suffer psychological symptoms of severe intensity. Our goal in this article is to review studies published in the last 20 years to compile what is known about posttraumatic stress disorder (PTSD) occurring after earthquakes. The review also describes other psychiatric complications that can be associated with earthquakes, to provide readers with better overall understanding, and discusses several sociodemographic factors that can be associated with post-earthquake PTSD Method A search for literature was conducted on major databases such as MEDLINE, PubMed, EMBASE, and PsycINFO and in neurology and psychiatry journals, and many other medical journals. Terms used for electronic searches included, but were not limited to, posttraumatic stress disorder (PTSD), posttraumatic symptoms, anxiety, depression, major depressive disorder, earthquake, and natural disaster. The relevant information was then utilized to determine the relationships between earthquakes and posttraumatic stress symptoms. Results It was found that PTSD is the most commonly occurring mental health condition among earthquake survivors. Major depressive disorder, generalized anxiety disorder, obsessive compulsive disorder, social phobia, and specific phobias were also listed. Conclusion The PTSD prevalence rate varied widely. It was dependent on multiple risk factors in target populations and also on the interval of time that had elapsed between the exposure to the deadly incident and measurement. Females seemed to be the most widely-affected group, while elderly people and young children exhibit considerable psychosocial impact.

Examining the latent structure mechanisms for comorbid posttraumatic stress disorder and major depressive disorder

2018 ◽  
Vol 229 ◽  
pp. 477-482 ◽  
Author(s):  
Margo C. Hurlocker ◽  
Desirae N. Vidaurri ◽  
Lisa-Ann J. Cuccurullo ◽  
Kelly Maieritsch ◽  
C. Laurel Franklin
Keyword(s):  
Posttraumatic Stress Disorder ◽  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Posttraumatic Stress ◽  
Stress Disorder ◽  
Latent Structure ◽  
Major Depressive
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