scholarly journals ∆133p53 isoform promotes tumour invasion and metastasis via interleukin-6 activation of JAK-STAT and RhoA-ROCK signalling

2018 ◽  
Vol 9 (1) ◽  
Author(s):  
Hamish Campbell ◽  
Nicholas Fleming ◽  
Imogen Roth ◽  
Sunali Mehta ◽  
Anna Wiles ◽  
...  
Keyword(s):  
Interleukin 6 ◽  
Tumour Invasion ◽  
Invasion And Metastasis

Mechanisms of tumour invasion and metastasis: emerging targets for therapy

2002 ◽  
Vol 6 (2) ◽  
pp. 217-233 ◽  
Author(s):  
Erik W Thompson ◽  
John T Price
Keyword(s):  
Tumour Invasion ◽  
Invasion And Metastasis

scholarly journals The Δ133p53 isoform and its mouse analogue Δ122p53 promote invasion and metastasis involving pro-inflammatory molecules interleukin-6 and CCL2

Oncogene ◽  
2016 ◽  
Vol 35 (38) ◽  
pp. 4981-4989 ◽  
Author(s):  
I Roth ◽  
H Campbell ◽  
C Rubio ◽  
C Vennin ◽  
M Wilson ◽  
...  
Keyword(s):  
Interleukin 6 ◽  
Invasion And Metastasis ◽  
Inflammatory Molecules

scholarly journals Tumour invasion and metastasis are promoted in mice deficient in tenascin-X

2001 ◽  
Vol 6 (12) ◽  
pp. 1101-1111 ◽  
Author(s):  
Ken-ichi Matsumoto ◽  
Noriyasu Takayama ◽  
Junji Ohnishi ◽  
Eriko Ohnishi ◽  
Yasuaki Shirayoshi ◽  
...  
Keyword(s):  
Tumour Invasion ◽  
Invasion And Metastasis

scholarly journals Erratum: Tumour invasion and metastasis initiated by microRNA-10b in breast cancer

Nature ◽  
2008 ◽  
Vol 455 (7210) ◽  
pp. 256-256 ◽  
Author(s):  
Li Ma ◽  
Julie Teruya-Feldstein ◽  
Robert A. Weinberg
Keyword(s):  
Breast Cancer ◽  
Tumour Invasion ◽  
Invasion And Metastasis

scholarly journals MicroRNA-107, an oncogene microRNA that regulates tumour invasion and metastasis by targeting DICER1 in gastric cancer

2011 ◽  
Vol 15 (9) ◽  
pp. 1887-1895 ◽  
Author(s):  
Xiaohua Li ◽  
Ying Zhang ◽  
Yongquan Shi ◽  
Guanglong Dong ◽  
Jie Liang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Tumour Invasion ◽  
Invasion And Metastasis

scholarly journals Approximate Analytical Solutions for Mathematical Model of Tumour Invasion and Metastasis Using Modified Adomian Decomposition and Homotopy Perturbation Methods

2014 ◽  
Vol 2014 ◽  
pp. 1-13 ◽  
Author(s):  
Norhasimah Mahiddin ◽  
S. A. Hashim Ali
Keyword(s):  
Decomposition Method ◽  
Nonlinear Partial Differential Equations ◽  
Adomian Decomposition Method ◽  
Nonlinear Problems ◽  
Slight Variation ◽  
Tumour Invasion ◽  
Invasion And Metastasis ◽  
Homotopy Perturbation ◽  
Approximate Analytical Solutions ◽  
Adomian Decomposition

The modified decomposition method (MDM) and homotopy perturbation method (HPM) are applied to obtain the approximate solution of the nonlinear model of tumour invasion and metastasis. The study highlights the significant features of the employed methods and their ability to handle nonlinear partial differential equations. The methods do not need linearization and weak nonlinearity assumptions. Although the main difference between MDM and Adomian decomposition method (ADM) is a slight variation in the definition of the initial condition, modification eliminates massive computation work. The approximate analytical solution obtained by MDM logically contains the solution obtained by HPM. It shows that HPM does not involve the Adomian polynomials when dealing with nonlinear problems.

Tumour invasion and metastasis: Therapeutic implications?

1986 ◽  
Vol 6 (2) ◽  
pp. 135-142 ◽  
Author(s):  
Marc M. Mareel ◽  
Marc E. Bracke ◽  
Erwin R. Boghaert
Keyword(s):  
Tumour Invasion ◽  
Invasion And Metastasis ◽  
Therapeutic Implications

scholarly journals Matrix metalloproteinases and their inhibitors in gastric cancer

Gut ◽  
1998 ◽  
Vol 43 (6) ◽  
pp. 791-797 ◽  
Author(s):  
G I Murray ◽  
M E Duncan ◽  
E Arbuckle ◽  
W T Melvin ◽  
J E Fothergill
Keyword(s):  
Gastric Cancer ◽  
Matrix Metalloproteinases ◽  
Paraffin Wax ◽  
Tumour Invasion ◽  
Invasion And Metastasis ◽  
Gastric Cancers ◽  
Formalin Fixed Paraffin ◽  
The Matrix ◽  
Normal Stomach ◽  
Formalin Fixed

Background—The matrix metalloproteinases (MMPs) and tissue inhibitors of matrix metalloproteinases (TIMPs) are strongly implicated in tumour invasion and metastasis.Aims—To investigate the presence of individual MMPs and TIMPs in gastric cancer.Methods—The presence of MMP-1, MMP-2, MMP-3, MMP-9, TIMP-1, and TIMP-2 was identified in a group of gastric cancers (n=74) by immunohistochemistry using monoclonal antibodies. These antibodies were effective on formalin fixed, paraffin wax embedded sections.Results—A large proportion (94%) of gastric cancers contained MMP-2; MMP-1 and MMP-9 were also detected in 73% and 70% of tumours respectively. MMP-3 was only present in 27% of tumours. MMP-1 and MMP-9 were found predominantly in intestinal type tumours. TIMP-1 and TIMP-2 were identified in 41% and 57% of tumours respectively. Immunoreactivity for individual MMPs or TIMPs was not identified in normal stomach.Conclusions—This study shows the presence of matrix metalloproteinases, particularly MMP-2, and TIMPs in stomach cancer. Antibodies which are effective in formalin fixed, paraffin wax embedded sections are useful for the identification of MMPs and TIMPs in diagnostic specimens.

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