scholarly journals Aberrant integration of Hepatitis B virus DNA promotes major restructuring of human hepatocellular carcinoma genome architecture

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Eva G. Álvarez ◽  
Jonas Demeulemeester ◽  
Paula Otero ◽  
Clemency Jolly ◽  
Daniel García-Souto ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepatitis B Virus ◽  
Liver Cancer ◽  
Hepatitis B ◽  
Human Hepatocellular Carcinoma ◽  
Tumour Suppressor Genes ◽  
Cancer Evolution ◽  
Sequencing Technologies ◽  
Timing Estimation ◽  
B Virus

AbstractMost cancers are characterized by the somatic acquisition of genomic rearrangements during tumour evolution that eventually drive the oncogenesis. Here, using multiplatform sequencing technologies, we identify and characterize a remarkable mutational mechanism in human hepatocellular carcinoma caused by Hepatitis B virus, by which DNA molecules from the virus are inserted into the tumour genome causing dramatic changes in its configuration, including non-homologous chromosomal fusions, dicentric chromosomes and megabase-size telomeric deletions. This aberrant mutational mechanism, present in at least 8% of all HCC tumours, can provide the driver rearrangements that a cancer clone requires to survive and grow, including loss of relevant tumour suppressor genes. Most of these events are clonal and occur early during liver cancer evolution. Real-time timing estimation reveals some HBV-mediated rearrangements occur as early as two decades before cancer diagnosis. Overall, these data underscore the importance of characterising liver cancer genomes for patterns of HBV integration.

scholarly journals Aberrant integration of Hepatitis B virus DNA promotes major restructuring of human hepatocellular carcinoma genome architecture

2021 ◽  
Author(s):  
Eva G Alvarez ◽  
Jonas Demeulemeester ◽  
Clemency Jolly ◽  
Daniel Garcia-Souto ◽  
Paula Otero ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Structural Variation ◽  
Human Hepatocellular Carcinoma ◽  
Cancer Evolution ◽  
Sequencing Technologies ◽  
B Virus ◽  
Cancer Types ◽  
Mutational Process

Most cancers are characterized by the somatic acquisition 52 of genomic rearrangements during tumour evolution that eventually drive the oncogenesis. There are different mutational mechanisms causing structural variation, some of which are specific to particular cancer types. Here, using multiplatform sequencing technologies, we identify and characterize a remarkable mutational mechanism in human hepatocellular carcinoma caused by Hepatitis B virus, by which DNA molecules from the virus are inserted into the tumour genome causing dramatic changes in its configuration, including non-homologous chromosomal fusions and megabase-size telomeric deletions. This aberrant mutational process, present in at least 8% of all HCC tumours, is active early during liver cancer evolution and can provide the driver rearrangements that a cancer clone requires to survive and grow.

Hepatitis B virus DNA integration and expression of an erb B-like gene in human hepatocellular carcinoma

1992 ◽  
Vol 188 (1) ◽  
pp. 344-351 ◽  
Author(s):  
Xiao-Kun Zhang ◽  
Jack O. Egan ◽  
Dao-pei Huang ◽  
Zhi-lin Sun ◽  
Victoria K.Y. Chien ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Human Hepatocellular Carcinoma ◽  
Hepatitis B Virus Dna ◽  
Dna Integration ◽  
B Virus

scholarly journals Hepatitis B virus X protein-mediated non-coding RNA aberrations in the development of human hepatocellular carcinoma

2017 ◽  
Vol 49 (2) ◽  
pp. e293-e293 ◽  
Author(s):  
Bei Zhang ◽  
Siqi Han ◽  
Bing Feng ◽  
Xiaoyuan Chu ◽  
Longbang Chen ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Human Hepatocellular Carcinoma ◽  
X Protein ◽  
Non Coding Rna ◽  
B Virus

scholarly journals The mode of hepatitis B virus DNA integration in chromosomes of human hepatocellular carcinoma.

1987 ◽  
Vol 1 (8) ◽  
pp. 773-782 ◽  
Author(s):  
T Nagaya ◽  
T Nakamura ◽  
T Tokino ◽  
T Tsurimoto ◽  
M Imai ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Human Hepatocellular Carcinoma ◽  
Hepatitis B Virus Dna ◽  
Dna Integration ◽  
B Virus

scholarly journals THE RISK OF HEPATOCELLULAR CARCINOMA ON PATIENTS DIAGNOSED WITH HEPATITIS B AND HEPATITIS D (2012-2015)

2016 ◽  
Vol 63 (2) ◽  
pp. 153-158
Author(s):  
Irina Dinu ◽  
◽  
Mihai Voiculescu ◽  
Andreea Radasan ◽  
◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepatitis B Virus ◽  
Liver Cancer ◽  
Hepatitis B ◽  
Urban Areas ◽  
Primary Liver Cancer ◽  
Close Monitoring ◽  
Hepatitis D ◽  
Mortality And Morbidity ◽  
B Virus

Introduction. Hepatocellular carcinoma is the most common primary liver cancer (90%), the 5th neoplasia in terms of incidence and the 3rd mortality cause worldwide (1). This increased mortality is the consequence of diagnosis in an advanced state and of the fact that most HCC develop based on a chronic hepatic pathology. In Romania, around 7% of the population is affected by chronic hepatitis B, the incidence of this disease being increased in urban areas (2). The sooner the hepatitis B virus infection occurs in life, the higher the probability is, for this to become chronic and to lead to cirrhosis or liver cancer. Hepatitis D only occurs among people who are infected with the Hepatitis B virus because HDV is an incomplete virus that requires the helper function of HBV to replicate. Objective of the study. The main purpose of the surveillance and/or screening is to decrease mortality and morbidity by means of liver cancer for patients diagnosed with hepatitis B and hepatitis D. Matherial and methods. The study was conducted on a number of 102 patients diagnosed with viral hepatitis (HBV, HDV+HBV) admitted at the “Fundeni” Hospital, Bucharest, between 2012-2015. Two batches of patients were taken into account (patients with hepatitis B and hepatitis D). The viral load and chosen treatment were clinically, biochemically and imagistically evaluated. Results. We have noticed a significant increase in patients diagnosed with hepatitis B and D. The existence of the hepatitis D infection in patients diagnosed with hepatitis B significantly increases the occurence potential of liver cancer. The hepatic destruction degree by means of cirrhotic liver occurence respectively hepatic cirrhosisis much higher for patients diagnosed with hepatitis D. Conclusions. The close monitoring of the patients in this research program brings real benefit for the prevention of liver cancer and diagnosing it early, having a much better prognosis on the quality of life.

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