Clinical, pathophysiologic, and genomic analysis of the outcomes of primary head and neck malignancy after pulmonary metastasectomy

Abstract The median overall survival (OS) of some head and neck malignancies, such as head and neck squamous cell carcinoma (HNSCC), with metastatic lesions was only 12 months. Whether aggressive pulmonary metastasectomy (PM) improves survival is controversial. Patients with primary head and neck malignancy undergoing PM were enrolled. Clinical outcomes were compared among different histological types. Whole-exome sequencing was used for matched pulmonary metastatic samples. The genes where genetic variants have been identified were sent for analysis by DAVID, IPA, and STRING. Forty-nine patients with primary head and neck malignancies were enrolled. Two-year postmetastasectomy survival (PMS) rates of adenoid cystic carcinoma, thyroid carcinoma, nasopharyngeal carcinoma, and HNSCC were 100%, 88.2%, 71.4%, and 59.2%, respectively (P = 0.024). In HNSCC, the time to distant metastasis was an independent predictive factor of the efficacy of PM. Several pathways, such as branched-chain amino acid (BCAA) consumption, were significantly associated with the progression of HNSCC [P < 0.001, fold enrichment (FE) = 5.45]. Moreover, metabolism-associated signaling pathways also seemed to be involved in cancer metastasis. Histological types and time to distant metastasis were important factors influencing the clinical outcomes of PM. For HNSCC, metabolic-associated signaling pathways were significantly associated with tumor progression and distant metastasis. Future validations are warranted.

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Factors causing delay in diagnosis of head and neck malignancy

International Journal of Otorhinolaryngology and Head and Neck Surgery ◽

10.18203/issn.2454-5929.ijohns20181856 ◽

2018 ◽

Vol 4 (3) ◽

pp. 708

Author(s):

Anushree R. Bajaj ◽

Shahnaz Sheikh ◽

Samir Joshi ◽

Bhalchandra Paike

Keyword(s):

Head And Neck ◽

Psychological Factors ◽

Head And Neck Malignancy ◽

Head And Neck Malignancies ◽

Delay In Diagnosis ◽

Neck Malignancy ◽

Diagnosis Of Cancer ◽

Ultimate Outcome ◽

Fear And Anxiety ◽

Delay Of Diagnosis

Background: Besides etiological factors there are lots of other factors which are responsible for the delay of diagnosis in head and neck malignancies. These include socio-demographic, institutional and other psychological factors. The aim of our article was to emphasize the importance of these unexplored factors in the delay of diagnosis of head and neck malignancies and make an effort to reduce those.Methods: A total of 40 cases of head and neck malignancies in ENT ward of DUPMC hospital were studied. A retrospective study was undertaken using proper history taking and analysis of the patients. Results: The factors causing delay in the diagnosis were found to delay due to psychological and behavioral 32.5%, delay due to symptom recognition 87.5%, delay due to socio demographic 45%, practioner delay-10%, hospital delay-5%.Conclusions: Measures must be taken to reduce the factors causing deal in diagnosis like, Fear and anxiety about ultimate outcome of cancer should be allayed through various media and stress should be laid on fact that early detection can alter outcome of cancer so as to induce the patient to seek medical help early. Facilities for diagnosis of cancer should be available at accessible centre and only treatment should be left to certain specialized centers.

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Study of serum adenosine deaminase levels in head and neck malignancies

International Journal of Otorhinolaryngology and Head and Neck Surgery ◽

10.18203/issn.2454-5929.ijohns20204634 ◽

2020 ◽

Vol 6 (11) ◽

pp. 2069

Author(s):

Sudhakar Rao M. S. ◽

Reshma P. R.

Keyword(s):

Early Diagnosis ◽

Head And Neck ◽

Adenosine Deaminase ◽

Primary Tumor ◽

Unknown Origin ◽

Prognostic Indicator ◽

Head And Neck Malignancy ◽

Head And Neck Malignancies ◽

Neck Malignancy ◽

Venous Sample

Background: Head and neck malignancies are the malignancies occurring at various sites like scalp, ear, nose and paranasal sinuses, nasopharynx, oral cavity, oropharynx, hypopharynx, larynx, and salivary glands. There are various biomarkers which aid in early diagnosis and management of head and neck malignancies. In order to study various parameters aiding in early diagnosis, this study has been taken up to estimate serum adenosine deaminase levels among these patients.Methods: Eighty-eight clinically diagnosed head and neck malignancy patients of both genders were included in this study on simple random basis. After obtaining the written informed consent from the patient, a peripheral venous sample of blood was taken and serum ADA levels were estimated. Data was analyzed using IBM SPSS Version 22.Results: Serum ADA levels are found to be statistically significant with respect to various stages of head and neck malignancies including malignancy of unknown origin. Mean ADA level in this study was 30.33 IU/l. Mean ADA levels in MUO, primary tumor with neck secondaries were 37 IU/l, 38.7 IU/l respectively. Mean ADA levels in patients with primary tumor without neck secondaries was 27.9 IU/l.Conclusions: The Serum ADA levels among head and neck malignancy patients including MUO is a simple, inexpensive diagnostic biomarker enzyme which is easy and rapid to estimate. This study emphasizes on using Serum ADA levels as a prognostic indicator among head and neck malignancies who are on various modalities of treatment.

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Neutrophilic Dermatosis of Hands as Oncological Finding: Importance of Follow-Up

ORL ◽

10.1159/000513630 ◽

2021 ◽

pp. 1-3

Author(s):

Jérôme R. Lechien ◽

Daphné Delplace ◽

Mohamad Khalife ◽

Sven Saussez

Keyword(s):

Head And Neck Cancer ◽

Head And Neck ◽

Neck Cancer ◽

Paraneoplastic Syndrome ◽

Tobacco Consumption ◽

Neutrophilic Dermatosis ◽

Pharyngeal Cancer ◽

Head And Neck Malignancy ◽

Neck Malignancy

Neutrophilic febrile dermatosis (NFD) is a rare paraneoplastic syndrome that may be found in patients with head and neck cancer. NFD may appear before the neoplasia and may only concern the dorsal faces of the hands. This article reports the NFD findings of a patient with pharyngeal cancer, which was developed 2 years after the occurrence of NFD. The development of NFD in patient with alcohol and tobacco consumption should lead otolaryngologists and dermatologists to suspect head and neck malignancy. In cases of normal otolaryngological examination, patients have to be followed.

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