scholarly journals Offset of openings in optic nerve head canal at level of Bruch’s membrane, anterior sclera, and lamina cribrosa

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Kyoung Min Lee ◽  
Hyoung Jun Ahn ◽  
Martha Kim ◽  
Sohee Oh ◽  
Seok Hwan Kim
Keyword(s):  
Optic Nerve ◽  
Optic Nerve Head ◽  
Lamina Cribrosa ◽  
Angular Deviation ◽  
Bruch's Membrane ◽  
Bruch’S Membrane ◽  
Bruch’S Membrane Opening

AbstractWe compared the central retinal vascular trunk (CRVT) position, as a surrogate of lamina cribrosa (LC) offset, with the anterior scleral opening (ASCO) offset from the Bruch’s membrane opening (BMO). Based on the BMO-centered radial scans, the BMO and ASCO margins were demarcated, and each center was determined as the center of the best-fitted ellipse for each margin. The ASCO/BMO offset was defined as the offset between each center. Angular deviations and the extent of ASCO and CRVT offsets from the BMO center were compared directly. Incomplete demarcation of ASCO was found in 20%, which was associated with a larger BMO area and a larger ASCO offset from the BMO. The angular deviation of ASCO offset was associated with that of CRVT offset and that of the longest externally oblique border. The ASCO offset was smaller than the CRVT offset, and, unlike the CRVT offset, it was rarely deviated to the inferior side. The complete ASCO margin might not be demarcatable when determined on BMO-centered radial scans in the presence of an offset. Also, the ASCO, which reflects only the superficial scleral layer, might not reflect the LC position, because the LC might be shifted further from the ASCO.

scholarly journals Offset of Openings in Optic Nerve Head Canal at Level of Bruch’s Membrane, Anterior Sclera, and Lamina Cribrosa

2021 ◽  
Author(s):  
Kyoung Min Lee ◽  
Hyoung Jun Ahn ◽  
Martha Kim ◽  
Sohee Oh ◽  
Seok Hwan Kim
Keyword(s):  
Optic Nerve ◽  
Optic Nerve Head ◽  
Lamina Cribrosa ◽  
Angular Deviation ◽  
Bruch's Membrane ◽  
Bruch’S Membrane ◽  
Bruch’S Membrane Opening

Abstract We compared the central retinal vascular trunk (CRVT) position, as a surrogate of lamina cribrosa (LC) offset, with the anterior scleral opening (ASCO) offset from the Bruch’s membrane opening (BMO). Based on the BMO-centered radial scans, the BMO and ASCO margins were demarcated, and each center was determined as the center of the best-fitted ellipse for each margin. The ASCO/BMO offset was defined as the offset between each center. Angular deviations and the extent of ASCO and CRVT offsets from the BMO center were compared directly. Incomplete demarcation of ASCO was found in 20%, which was associated with a larger BMO area and a larger ASCO offset from the BMO. The angular deviation of ASCO offset was associated with that of CRVT offset and that of the longest externally oblique border. The ASCO offset was smaller than the CRVT offset, and, unlike the CRVT offset, it was rarely deviated to the inferior side. The complete ASCO margin might not be demarcateable when determined on BMO-centered radial scans in the presence of an offset. Also, the ASCO, which reflects only the superficial scleral layer, might not reflect the LC position, because the LC might be shifted further from the ASCO.

scholarly journals Bruch’s membrane opening enlargement and its implication on the myopic optic nerve head

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Mi Sun Sung ◽  
Min Young Heo ◽  
Hwan Heo ◽  
Sang Woo Park
Keyword(s):  
Optic Nerve ◽  
Optic Nerve Head ◽  
Lamina Cribrosa ◽  
Cross Sectional Study ◽  
Multivariate Regression Model ◽  
Bruch's Membrane ◽  
Bruch’S Membrane ◽  
Cross Sectional ◽  
Bruch’S Membrane Opening ◽  
Parapapillary Atrophy

AbstractWe examined the association between Bruch’s membrane opening (BMO) area and various ocular parameters and investigated the implication of BMO enlargement on the myopic optic nerve head. One hundred eighty-five myopic eyes were included in this cross-sectional study. Among the included eyes, 53 having axial lengths between 26 and 27 mm were further analyzed to investigate the association between BMO area and various ocular parameters. BMO area, BMO-minimum rim width (BMO-MRW), peripapillary choroidal thickness (pCT), width of β-parapapillary atrophy with and without Bruch’s membrane (PPA+BM and PPA−BM), and presence of lamina cribrosa (LC) defect were evaluated. We found that BMO area tended to increase with increasing axial length, but varied among the highly myopic eyes even though they had similar degrees of myopia. In the subgroup analysis of eyes with axial lengths between 26 and 27 mm, BMO area was highly variable and it significantly correlated with PPA−BM width and temporal-inferior, nasal-inferior, and nasal BMO-MRW and pCT. LC defects were more common in myopic eyes with enlarged BMO. A multivariate regression model revealed that higher intraocular pressure, enlarged BMO, and thinner BMO-MRW were associated with LC defects in highly myopic eyes. These findings should be considered when evaluating myopic eyes.

scholarly journals Pattern Electroretinogram Parameters Are Associated with Optic Nerve Morphology in Preperimetric Glaucoma after Adjusting for Disc Area

2021 ◽  
Vol 2021 ◽  
pp. 1-12
Author(s):  
Andrew Tirsi ◽  
Vasiliki Gliagias ◽  
Julie Moehringer ◽  
Derek Orshan ◽  
Sofia Tello ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Retinal Nerve Fiber Layer ◽  
Pattern Electroretinogram ◽  
Bruch's Membrane ◽  
Bruch’S Membrane ◽  
Fiber Layer ◽  
Disc Area ◽  
Preperimetric Glaucoma ◽  
Bruch’S Membrane Opening ◽  
Retinal Nerve Fiber

Purpose. We examined the relationships between pattern electroretinogram and optical coherence tomography derived optic nerve head measurements, after controlling for disc area. Methods. Thirty-two eyes from 20 subjects with preperimetric glaucoma underwent pattern electroretinogram and optical coherence tomography. Pattern electroretinogram parameters (Magnitude, MagnitudeD, and MagnitudeD/Magnitude ratio) and optic nerve head measurements (rim area, average cup to disc ratio, vertical cup to disc ratio, cup volume, retinal nerve fiber layer thickness sectors, and Bruch’s membrane opening-minimum rim width thickness sectors) were analyzed after controlling for disc area. Results. Magnitude and MagnitudeD were significantly associated with rim area (r ≥ 0.503, p ≤ 0.004 ). All pattern electroretinogram parameters significantly correlated with Bruch’s membrane opening-minimum rim width sectors—temporal superior and nasal inferior (r = 0.400, p = 0.039 )—and retinal nerve fiber layer sectors—superior, nasal superior, and inferior (r ≥ 0.428, p ≤ 0.026 ). Magnitude and MagnitudeD explained an additional 26.8% and 25.2% of variance in rim area (B = 0.174 (95% CI: 0.065, 0.283), p = 0.003 , and B = 0.160 (95% CI: 0.056, 0.265), p = 0.004 ), respectively. MagnitudeD and MagnitudeD/Magnitude ratio explained an additional 13.4% and 12.8% of the variance in Bruch’s membrane opening-minimum rim width global (B = 38.921 [95% CI: 3.872, 73.970], p = 0.031 , and B = 129.024 (95% CI: 9.589, 248.460), p = 0.035 ), respectively. All Bruch’s membrane opening-minimum rim width sectors and retinal nerve fiber layer sectors (nasal superior, nasal inferior, and inferior) were significantly correlated with rim area (r ≥ 0.389, p ≤ 0.045 ). Conclusion. PERG abnormalities can predict rim area loss in preperimetric glaucoma after controlling for disc area. We recommend controlling for disc area to increase diagnostic accuracy in early glaucoma.

Bruch's membrane opening changes and lamina cribrosa displacement in non-arteritic anterior ischaemic optic neuropathy

2016 ◽  
Vol 101 (2) ◽  
pp. 143-149 ◽  
Author(s):  
Gema Rebolleda ◽  
Javier García-Montesinos ◽  
Elisabet De Dompablo ◽  
Noelia Oblanca ◽  
Francisco J Muñoz-Negrete ◽  
...  
Keyword(s):  
Optic Neuropathy ◽  
Lamina Cribrosa ◽  
Bruch's Membrane ◽  
Bruch’S Membrane ◽  
Ischaemic Optic Neuropathy ◽  
Anterior Ischaemic Optic Neuropathy ◽  
Bruch’S Membrane Opening

scholarly journals Biomechanical Properties of Bruch's Membrane–Choroid Complex and Their Influence on Optic Nerve Head Biomechanics

2018 ◽  
Vol 59 (7) ◽  
pp. 2808 ◽  
Author(s):  
Xiaofei Wang ◽  
Clarence Ken Guan Teoh ◽  
Anita S. Y. Chan ◽  
Sathiyan Thangarajoo ◽  
Jost B. Jonas ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Optic Nerve Head ◽  
Biomechanical Properties ◽  
Bruch's Membrane ◽  
Bruch’S Membrane

scholarly journals Bruch’s Membrane Opening Minimum Rim Width Measurement with SD-OCT: A Method to Correct for the Opening Size of Bruch’s Membrane

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Robert Kromer ◽  
Martin Stephan Spitzer
Keyword(s):  
Optic Nerve ◽  
Internal Limiting Membrane ◽  
Bruch's Membrane ◽  
Bruch’S Membrane ◽  
Fiber Layer ◽  
Future Studies ◽  
Nerve Fiber Layer Thickness ◽  
Bruch’S Membrane Opening ◽  
The Mean ◽  
Sd Oct

A precise evaluation of the retinal nerve fiber layer thickness (RNFLT) is key for diagnosing and monitoring glaucoma. The Bruch’s membrane opening minimum rim width (BMO-MRW) has been proposed as a reproducible assessment of the optic nerve. The BMO-MRW measures the minimum distance from the BMO to the internal limiting membrane. We propose an approach to correct the BMO-MRW using the BMO size for increased accuracy in interindividual comparisons in future studies. Eighty-one healthy patients received SPECTRALIS spectral domain optical coherence tomography measurements for the peripapillary RNFLT and BMO-MRW. We calculated a BMO size-corrected BMO-MRW using the mean BMO size of our cohort. BMO size was defined using the manufacturer-provided BMO area and manually measured BMO perimeter. We observed that the BMO-MRW correlated highly with the perimeter (r=−0.553, p<0.0001) and the area of the BMO (r=−0.546, p<0.0001). Using these parameters, we provided a corrected BMO size-adjusted BMO-MRW which was better correlated with the RNFLT compared to the noncorrected one (z=−3.3495, p=0.0004). We demonstrated the dependency of the BMO-MRW on ONH size. Furthermore, we showed the superiority of the corrected BMO-MRW using either the manually measured optic nerve head perimeter or the automatically provided ONH for future studies.

Lamina cribrosa position and Bruch’s membrane opening differences between anterior ischemic optic neuropathy and open-angle glaucoma

2018 ◽  
Vol 29 (2) ◽  
pp. 202-209 ◽  
Author(s):  
Gema Rebolleda ◽  
Ane Pérez-Sarriegui ◽  
Laura Díez-Álvarez ◽  
Victoria De Juan ◽  
Francisco J Muñoz-Negrete
Keyword(s):  
Optic Neuropathy ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Lamina Cribrosa ◽  
Anterior Ischemic Optic Neuropathy ◽  
Ischemic Optic Neuropathy ◽  
Open Angle ◽  
Bruch's Membrane ◽  
Bruch’S Membrane ◽  
Bruch’S Membrane Opening

Purpose: To compare the optic nerve head morphology among primary open-angle glaucoma, non-arteritic anterior ischemic optic neuropathy eyes, their fellow healthy eyes and control eyes, using spectral-domain optical coherence tomography with enhanced depth imaging. Methods: Observational cross-sectional study including 88 eyes of 68 patients. In this study, 23 non-arteritic anterior ischemic optic neuropathy eyes, 17 fellow unaffected eyes, 25 primary open-angle glaucoma eyes, and 23 age-matched control eyes were included. Peripapillary retinal nerve fiber layer thickness and optic disk area were evaluated. Bruch’s membrane opening diameter, optic cup depth, anterior lamina cribrosa depth, and prelaminar tissue thickness were assessed. Results: Non-arteritic anterior ischemic optic neuropathy and primary open-angle glaucoma eyes had similar visual field mean deviation and peripapillary retinal nerve fiber layer thickness (P = 0.6 and P = 0.56, respectively). Bruch’s membrane opening diameter was significantly larger in primary open-angle glaucoma eyes than in control eyes (P = 0.02). Lamina cribrosa and disk cup were deeper in eyes with primary open-angle glaucoma than both control and non-arteritic anterior ischemic optic neuropathy eyes (P < 0.001). Prelaminar tissue thickness was significantly thinner in primary open-angle glaucoma eyes than in non-arteritic anterior ischemic optic neuropathy eyes (P < 0.001). Lamina cribrosa was shallower in both non-arteritic anterior ischemic optic neuropathy and unaffected fellow eyes compared to healthy eyes (P < 0.001 and P = 0.04, respectively). No differences were found in the optic disk area. Conclusion: A forward lamina cribrosa placement and not a smaller disk could be involved in the pathogenesis of non-arteritic anterior ischemic optic neuropathy. A significantly larger Bruch’s membrane opening diameter was found in primary open-angle glaucoma eyes compared with control eyes. This issue has clinical implications because Bruch’s membrane opening has been considered a stable reference for disk-related measures.

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