Role of nitric oxide and septide-insensitive NK1
 receptors in bronchoconstriction induced by aerosolised neurokinin A in guinea-pigs

Airway function is largely preserved during exercise or isocapnic hyperventilation in humans and guinea pigs despite likely changes in airway milieu during hyperpnea. It is only on cessation of a hyperpneic challenge that airway function deteriorates significantly. We tested the hypothesis that nitric oxide, a known bronchodilator that is produced in the lungs and bronchi, might be responsible for the relative bronchodilation observed during hyperventilation (HV) in guinea pigs. Three groups of anesthetized guinea pigs were given saline and three groups given 50 mg/kg N G-monomethyl-l-arginine (l-NMMA), a potent nitric oxide synthase inhibitor. Three isocapnic ventilation groups included normal ventilation [40 breaths/min, 6 ml/kg tidal volume (Vt)], increased respiratory rate only (150 breaths/min, 6 ml/kg Vt), and increased respiratory rate and increased volume (100 breaths/min, 8 ml/kg Vt). l-NMMA reduced expired nitric oxide in all groups. Expired nitric oxide was slightly but significantly increased by HV in the saline groups. However, inhibition of nitric oxide production had no significant effect on rate of rise of respiratory system resistance (Rrs) during HV or on the larger rise in Rrs seen 6 min after HV. We conclude that nitric oxide synthase inhibition has no effect on changes in Rrs, either during or after HV in guinea pigs.

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Role of nitric oxide in the development and partial reversal of allergen-induced airway hyperreactivity in conscious, unrestrained guinea-pigs

British Journal of Pharmacology ◽

10.1038/sj.bjp.0701738 ◽

1998 ◽

Vol 123 (7) ◽

pp. 1450-1456 ◽

Cited By ~ 40

Author(s):

Martin Schuiling ◽

Annet B. Zuidhof ◽

Monique A. A. Bonouvrie ◽

Nicolette Venema ◽

Johan Zaagsma ◽

...

Keyword(s):

Nitric Oxide ◽

Guinea Pigs ◽

Airway Hyperreactivity ◽

Partial Reversal

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The Role of Nitric Oxide in Digoxin-Induced Arrhythmias in Guinea-Pigs*

Pharmacology & Toxicology ◽

10.1111/j.1600-0773.1999.tb02103.x ◽

1999 ◽

Vol 84 (1) ◽

pp. 3-8 ◽

Cited By ~ 9

Author(s):

Sedat Altuǧ ◽

Özge Uzun ◽

A. Tuncay Demiryürek ◽

İclal Çakıcı ◽

Nurettin Abacıoǧlu ◽

...

Keyword(s):

Nitric Oxide ◽

Guinea Pigs

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Role of nitric oxide in hyperpnea-induced bronchoconstriction and airway microvascular permeability in guinea pigs

Experimental Lung Research ◽

10.3109/01902140903103464 ◽

2010 ◽

Vol 36 (2) ◽

pp. 67-74 ◽

Cited By ~ 1

Author(s):

Patrícia Pennacchioni-Alves ◽

Rodolfo Paula Vieira ◽

Fernanda Degobi Tenório Quirino Santos Lopes ◽

Fernanda Magalhaes Arantes-Costa ◽

Fabia B. Pianheri ◽

...

Keyword(s):

Nitric Oxide ◽

Guinea Pigs ◽

Microvascular Permeability

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Nociceptive inhibition of migrating myoelectric complex by nitric oxide and monoaminergic pathways in the rat

AJP Gastrointestinal and Liver Physiology ◽

10.1152/ajpgi.1998.274.3.g480 ◽

1998 ◽

Vol 274 (3) ◽

pp. G480-G486

Author(s):

Per M. Hellström ◽

Mikael Thollander ◽

Elvar Theodorsson

Keyword(s):

Nitric Oxide ◽

Cycle Length ◽

Intraperitoneal Administration ◽

Neurokinin A ◽

Migrating Myoelectric Complex ◽

Calcitonin Gene ◽

Dopaminergic Mechanisms ◽

Intraperitoneal Instillation ◽

Stimulation Of

This study investigated the role of nitric oxide (NO) and adrenergic and dopaminergic mechanisms in reflex inhibition of the migrating myoelectric complex (MMC) after intraperitoneal administration of acid in rats. Acid instilled immediately after an activity front inhibited the migrating complex and prolonged the cycle length from 13.0 ± 0.7 to 98.5 ± 17.2 min ( P < 0.001). Administration of Nω-nitro-l-arginine, reserpine, or guanetidine before acid decreased the prolonged cycle length to 18.1 ± 2.8 ( P < 0.001), 19.0 ± 2.0 ( P < 0.001), and 27.5 ± 9.3 min ( P < 0.001), respectively. Similarly, haloperidol given before acid shortened the prolonged cycle length to 46.7 ± 5.2 min ( P < 0.05). There was no effect of phentolamine in combination with propranolol or hexamethonium given alone. After intraperitoneal instillation of acid there was an increase in the plasma levels of somatostatin and a decrease of calcitonin gene-related peptide, but there was no change of neuropeptide Y, vasoactive intestinal peptide, substance P, neurokinin A, or neurotensin. The results indicate that NO and adrenergic, dopaminergic, and somatostatinergic mechanisms cooperate in inhibiting the MMC after nociceptive stimulation of the peritoneum.

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