scholarly journals The antiarrhythmic effects of ischaemic preconditioning in anaesthetized dogs are prevented by atropine; role of changes in baroreceptor reflex sensitivity

2002 ◽  
Vol 135 (1) ◽  
pp. 55-64 ◽  
Author(s):  
László Babai ◽  
Julius Gy Papp ◽  
James R Parratt ◽  
Ágnes Végh
Keyword(s):  
Baroreceptor Reflex ◽  
Ischaemic Preconditioning ◽  
Baroreceptor Reflex Sensitivity ◽  
Antiarrhythmic Effects

scholarly journals Differential Neuroprotection of Selective Estrogen Receptor Agonists against Autonomic Dysfunction and Ischemic Cell Death in Permanent versus Reperfusion Injury

2011 ◽  
Vol 2011 ◽  
pp. 1-9 ◽  
Author(s):  
Barry J. Connell ◽  
Tarek M. Saleh
Keyword(s):  
Cell Death ◽  
Estrogen Receptor ◽  
Reperfusion Injury ◽  
Autonomic Dysfunction ◽  
Ischemia Reperfusion ◽  
Baroreceptor Reflex ◽  
Receptor Subtypes ◽  
Baroreceptor Reflex Sensitivity ◽  
Dose Dependent

In the present study, we tested the hypothesis that selective activation of estrogen receptor subtypes (ERαand ERβ) would be neuroprotective following ischemia and/or ischemia-reperfusion, as well as prevent the associated autonomic dysfunction. The selective ERαagonist, PPT, when administered 30 min prior to occlusion of the middle cerebral artery (pMCAO), resulted in a dose-dependent neuroprotection as measured 6 hours postpermanent MCAO, but not following 30 mins of MCAO followed by 5.5 hrs of reperfusion (I/R). In contrast, 30 min pretreatment with the selective ERβagonist, DPN, resulted in a dose-dependent neuroprotection following I/R, but was not protective following pMCAO. Both drugs prevented the ischemia-induced autonomic dysfunction as measured by a decrease in the baroreceptor reflex sensitivity (BRS). The data presented here suggest a differential role of each ER subtype in targeting the mechanisms of cell death that occur in ischemia versus reperfusion injury.

scholarly journals Remote vs. ischaemic preconditioning: the differential role of mitogen-activated protein kinase pathways

2007 ◽  
Vol 78 (1) ◽  
pp. 108-115 ◽  
Author(s):  
M. Heidbreder ◽  
A. Naumann ◽  
K. Tempel ◽  
P. Dominiak ◽  
A. Dendorfer
Keyword(s):  
Protein Kinase ◽  
Mitogen Activated Protein Kinase ◽  
Ischaemic Preconditioning ◽  
Mitogen Activated Protein
Sign in / Sign up

Export Citation Format

Share Document