scholarly journals Irradiation-induced progenitor cell death in the developing brain is resistant to erythropoietin treatment and caspase inhibition

2004 ◽  
Vol 11 (11) ◽  
pp. 1166-1178 ◽  
Author(s):  
H Fukuda ◽  
A Fukuda ◽  
C Zhu ◽  
L Korhonen ◽  
J Swanpalmer ◽  
...  
Keyword(s):  
Cell Death ◽  
Progenitor Cell ◽  
Developing Brain ◽  
Caspase Inhibition ◽  
Erythropoietin Treatment

Caspase inhibition blocks apoptosis caused by MLL-AF4 depletion in t(4;11) positive ALL cell lines, but cannot abrogate subsequent necroptosis-like cell death

2009 ◽  
Vol 221 (03) ◽  
Author(s):  
P Garrido Castro ◽  
A Gessner ◽  
J Greil ◽  
HJ Vormoor ◽  
O Heidenreich
Keyword(s):  
Cell Death ◽  
Cell Lines ◽  
Caspase Inhibition

Triggers of Cell Death in the Developing Brain

2011 ◽  
Vol 7 (4) ◽  
pp. 293-300 ◽  
Author(s):  
Chrysanthy Ikonomidou
Keyword(s):  
Cell Death ◽  
Developing Brain

The glutaminergic, GABAergic, dopaminergic but not cholinergic neurons are susceptible to anaesthesia-induced cell death in the rat developing brain

Neuroscience ◽  
2011 ◽  
Vol 174 ◽  
pp. 64-70 ◽  
Author(s):  
Z.-W. Zhou ◽  
Y. Shu ◽  
M. Li ◽  
X. Guo ◽  
C. Pac-Soo ◽  
...  
Keyword(s):  
Cell Death ◽  
Cholinergic Neurons ◽  
Developing Brain

scholarly journals Programmed Cell Death Is Impaired in the Developing Brain ofFmr1Mutants

2013 ◽  
Vol 35 (4) ◽  
pp. 347-358 ◽  
Author(s):  
Ying Cheng ◽  
Joshua G. Corbin ◽  
Richard J. Levy
Keyword(s):  
Cell Death ◽  
Programmed Cell Death ◽  
Developing Brain

Mechanisms of Ischemic Cell Death in the Developing Brain

2007 ◽  
pp. 209-233 ◽  
Author(s):  
Z. S. Vexler ◽  
D. M. Ferriero
Keyword(s):  
Cell Death ◽  
Developing Brain

scholarly journals Caspase inhibition impaired the neural stem/progenitor cell response after cortical ischemia in mice

Oncotarget ◽  
2015 ◽  
Vol 7 (3) ◽  
pp. 2239-2248 ◽  
Author(s):  
Ahmed M. Osman ◽  
Susanne Neumann ◽  
H. Georg Kuhn ◽  
Klas Blomgren
Keyword(s):  
Cell Response ◽  
Progenitor Cell ◽  
Caspase Inhibition ◽  
Cortical Ischemia

Matrix metalloproteinase 9 regulates cell death following pilocarpine-induced seizures in the developing brain

2012 ◽  
Vol 48 (3) ◽  
pp. 339-347 ◽  
Author(s):  
Yvonne Hoehna ◽  
Ortrud Uckermann ◽  
Hella Luksch ◽  
Vanya Stefovska ◽  
Jenny Marzahn ◽  
...  
Keyword(s):  
Cell Death ◽  
Matrix Metalloproteinase ◽  
Matrix Metalloproteinase 9 ◽  
Developing Brain ◽  
Metalloproteinase 9

scholarly journals Consumption of a Blueberry-Enriched Diet by Women for 6 Weeks Alters Determinants of Human Muscle Progenitor Cell Function

2020 ◽  
Vol 150 (9) ◽  
pp. 2412-2418 ◽  
Author(s):  
Jamie E Blum ◽  
Brandon J Gheller ◽  
Sinwoo Hwang ◽  
Erica Bender ◽  
Mary Gheller ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cell Death ◽  
Oxygen Consumption ◽  
Muscle Regeneration ◽  
Progenitor Cell ◽  
Human Muscle ◽  
Skeletal Muscle Regeneration ◽  
Dietary Interventions ◽  
Freeze Dried ◽  
Muscle Progenitor Cell

ABSTRACT Background Human muscle progenitor cell (hMPC) function facilitates skeletal muscle regeneration and is influenced by circulating factors. Yet it is unknown whether dietary interventions impact hMPC function. Blueberry consumption was examined due to the pro-proliferative and antioxidant effects of blueberries and blueberry-derived compounds. Objectives This study measured indicators of hMPC function in young and old cultures treated with serum collected from a blueberry-enriched diet (BED) intervention. Methods Younger (21–40 y, n = 12) and older (60–79 y, n = 10) women consumed a 6-wk BED (38 g of freeze-dried blueberries daily). Fasting serum was collected at 0, 4, and 6 wk, and a fed serum sample at 1.5 h (acute) after starting the BED intervention. Young and old hMPCs, derived from 3–5 distinct donors (biological replicates), were individually cultured in media containing pooled, age-group–matched serum from each time point. Determinants of hMPC function (e.g., hMPC number, oxidative stress resistance, and upregulation of metabolic pathways) were measured and compared within age groups. Results Culturing young hMPCs in acute (compared with 0 wk) BED serum did not alter hMPC number or oxidative stress–induced cell death, but increased cellular oxygen consumption (29%, P = 0.026). Culturing young hMPCs in 6-wk (compared with 0-wk) BED serum increased hMPC number (40%, P = 0.0024), conferred minor resistance to oxidative stress–induced cell death (12.6 percentage point decrease, P = 0.10), and modestly increased oxygen consumption (36%, P = 0.09). No beneficial effect of the acute or long-term BED serum was observed in old hMPCs. Conclusions In younger women, dietary interventions could be a feasible strategy to improve hMPC function and thus muscle regeneration, through altering the serum environment. This study was registered at clinicaltrials.gov (NCT04262258).

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