scholarly journals Crystal structures of autoinhibitory PDZ domain of Tamalin: implications for metabotropic glutamate receptor trafficking regulation

2007 ◽  
Vol 26 (8) ◽  
pp. 2192-2205 ◽  
Author(s):  
Takuma Sugi ◽  
Takuji Oyama ◽  
Takanori Muto ◽  
Shigetada Nakanishi ◽  
Kosuke Morikawa ◽  
...  
Keyword(s):  
Crystal Structures ◽  
Glutamate Receptor ◽  
Metabotropic Glutamate Receptor ◽  
Pdz Domain ◽  
Receptor Trafficking ◽  
Metabotropic Glutamate ◽  
Glutamate Receptor Trafficking

scholarly journals Metabotropic Glutamate Receptor Trafficking and its Role in Drug-Induced Neurobehavioral Plasticity

2021 ◽  
pp. 1-16
Author(s):  
Peter U. Hámor ◽  
Marek Schwendt
Keyword(s):  
Glutamate Receptor ◽  
Membrane Trafficking ◽  
Metabotropic Glutamate Receptor ◽  
Neuropsychiatric Disorders ◽  
Surface Expression ◽  
Receptor Trafficking ◽  
Fine Tuning ◽  
Cell Surface Expression ◽  
Metabotropic Glutamate ◽  
Glutamate Receptor Trafficking

Glutamate is the major excitatory neurotransmitter in the mammalian central nervous system that guides developmental and experience-dependent changes in many cellular substrates and brain circuits, through the process collectively referred to as neurobehavioral plasticity. Regulation of cell surface expression and membrane trafficking of glutamate receptors represents an important mechanism that assures optimal excitatory transmission, and at the same time, also allows for fine-tuning neuronal responses to glutamate. On the other hand, there is growing evidence implicating dysregulated glutamate receptor trafficking in the pathophysiology of several neuropsychiatric disorders. This review provides up-to-date information on the molecular determinants regulating trafficking and surface expression of metabotropic glutamate (mGlu) receptors in the rodent and human brain and discusses the role of mGluR trafficking in maladaptive synaptic plasticity produced by addictive drugs. As substantial evidence links glutamatergic dysfunction to the progression and the severity of drug addiction, advances in our understanding of mGluR trafficking may provide opportunities for the development of novel pharmacotherapies of addiction and other neuropsychiatric disorders.

scholarly journals Activation of Metabotropic Glutamate Receptor 1 Accelerates NMDA Receptor Trafficking

2001 ◽  
Vol 21 (16) ◽  
pp. 6058-6068 ◽  
Author(s):  
Jian-yu Lan ◽  
Vytenis A. Skeberdis ◽  
Teresa Jover ◽  
Xin Zheng ◽  
Michael V. L. Bennett ◽  
...  
Keyword(s):  
Nmda Receptor ◽  
Glutamate Receptor ◽  
Metabotropic Glutamate Receptor ◽  
Receptor Trafficking ◽  
Metabotropic Glutamate ◽  
Metabotropic Glutamate Receptor 1

scholarly journals Palmitoylation-dependent regulation of glutamate receptors and their PDZ domain-containing partners

2013 ◽  
Vol 41 (1) ◽  
pp. 72-78 ◽  
Author(s):  
Gareth M. Thomas ◽  
Richard L. Huganir
Keyword(s):  
Synaptic Transmission ◽  
Glutamate Receptors ◽  
Glutamate Receptor ◽  
Pdz Domain ◽  
Receptor Trafficking ◽  
Ionotropic Glutamate Receptor ◽  
Novel Treatments ◽  
Neuronal Regulation ◽  
Glutamate Receptor Trafficking ◽  
And Function

In recent years, it has become clear that both AMPA (α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid)- and NMDA (N-methyl-D-aspartate)-type glutamate receptors, and many of their interacting partners, are palmitoylated proteins. Interfering with palmitoylation dramatically affects receptor trafficking and distribution and, in turn, can profoundly alter synaptic transmission. Increased knowledge of synaptic palmitoylation not only will aid our understanding of physiological neuronal regulation, but also may provide insights into, and even novel treatments for, neuropathological conditions. In the present paper, we review recent advances regarding the regulation of ionotropic glutamate receptor trafficking and function by palmitoylation.

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