scholarly journals Characterization of novel safe lentiviral vectors derived from simian immunodeficiency virus (SIVmac251) that efficiently transduce mature human dendritic cells

Gene Therapy ◽  
2000 ◽  
Vol 7 (19) ◽  
pp. 1613-1623 ◽  
Author(s):  
D Nègre ◽  
P-E Mangeot ◽  
G Duisit ◽  
S Blanchard ◽  
P-O Vidalain ◽  
...  
2006 ◽  
Vol 20 (5) ◽  
Author(s):  
Ning‐Sun Yang ◽  
Chien‐Yu Wang ◽  
Vani Staniforth ◽  
Ming‐Tsang Chiao ◽  
Po‐Jen Yen ◽  
...  

2015 ◽  
Vol 89 (7) ◽  
pp. 4030-4034 ◽  
Author(s):  
Véronique Barateau ◽  
Xuan-Nhi Nguyen ◽  
Fanny Bourguillault ◽  
Grégory Berger ◽  
Stéphanie Cordeil ◽  
...  

The block toward human immunodeficiency virus type 1 (HIV-1) infection of dendritic cells (DCs) can be relieved by Vpx (viral protein X), which degrades sterile alpha motif-hydroxylase domain 1 (SAMHD1) or by exogenously added deoxynucleosides (dNs), lending support to the hypothesis that SAMHD1 acts by limiting deoxynucleoside triphosphates (dNTPs). This notion has, however, been questioned. We show that while dNs and Vpx increase the infectivity of HIV-1, only the latter restores the infectivity of a simian immunodeficiency virus of macaques variant, SIVMACΔVpx virus. This distinct behavior seems to map to CA, suggesting that species-specific CA interactors modulate infection of DCs.


2009 ◽  
Vol 6 (1) ◽  
pp. 27-33 ◽  
Author(s):  
Guoyan Liu ◽  
Shuxun Liu ◽  
Ping Li ◽  
Ling Tang ◽  
Yanmei Han ◽  
...  

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