Faculty Opinions recommendation of Rapid influx and death of plasmacytoid dendritic cells in lymph nodes mediate depletion in acute simian immunodeficiency virus infection.

2009 ◽  
Author(s):  
Jason Brenchley ◽  
Nichole Klatt
Keyword(s):  
Dendritic Cells ◽  
Virus Infection ◽  
Lymph Nodes ◽  
Simian Immunodeficiency Virus ◽  
Plasmacytoid Dendritic Cells ◽  
Simian Immunodeficiency Virus Infection ◽  
Immunodeficiency Virus

scholarly journals Nonpathogenesis of Simian Immunodeficiency Virus Infection Is Associated with Reduced Inflammation and Recruitment of Plasmacytoid Dendritic Cells to Lymph Nodes, Not to Lack of an Interferon Type I Response, during the Acute Phase

2009 ◽  
Vol 84 (4) ◽  
pp. 1838-1846 ◽  
Author(s):  
Laure Campillo-Gimenez ◽  
Mireille Laforge ◽  
Michèle Fay ◽  
Audrey Brussel ◽  
Marie-Christine Cumont ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Virus Infection ◽  
Lymph Nodes ◽  
Simian Immunodeficiency Virus ◽  
Rhesus Macaques ◽  
Plasmacytoid Dendritic Cells ◽  
Simian Immunodeficiency Virus Infection ◽  
Type I ◽  
Immunodeficiency Virus ◽  
Tlr9 Signaling

ABSTRACT Divergent Toll-like receptor 7 (TLR7) and TLR9 signaling has been proposed to distinguish pathogenic from nonpathogenic simian immunodeficiency virus infection in primate models. We demonstrate here that increased expression of type I interferon in pathogenic rhesus macaques compared to nonpathogenic African green monkeys was associated with the recruitment of plasmacytoid dendritic cells in the lymph nodes and the presence of an inflammatory environment early after infection, instead of a difference in the TLR7/9 response.

scholarly journals Chemokine and Cytokine Mediated Loss of Regulatory T Cells in Lymph Nodes during Pathogenic Simian Immunodeficiency Virus Infection

2008 ◽  
Vol 180 (8) ◽  
pp. 5530-5536 ◽  
Author(s):  
Shulin Qin ◽  
Yongjun Sui ◽  
Adam C. Soloff ◽  
Beth A. Fallert Junecko ◽  
Denise E. Kirschner ◽  
...  
Keyword(s):  
T Cells ◽  
Virus Infection ◽  
Regulatory T Cells ◽  
Lymph Nodes ◽  
Simian Immunodeficiency Virus ◽  
Simian Immunodeficiency Virus Infection ◽  
Immunodeficiency Virus
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