Object
The goal of this study was to evaluate gene delivery to a benign brain tumor.
Methods
A recombinant adenovirus vector bearing the Escherichia coli ß-galactosidase reporter gene was selectively injected into the vascular supply of a spontaneously occurring canine olfactory groove meningioma. The tumor and a small amount of peritumoral brain tissue were removed 5 days after viral injection and stained with X-Gal to assess gene delivery. The authors noted significant ß-galactosidase gene expression by the tumor, but not by surrounding brain tissue. No obvious viral-related cytotoxicity was noted.
Conclusions
The authors found that meningiomas can be successfully transduced by adenovirus vectors by using endovascular techniques.
Efficient repetitive gene delivery to skeletal muscle using recombinant adenovirus vector containing the Coxsackievirus and adenovirus receptor cDNA
