Synthesis, in vivo evaluation and direct comparison with [18F]FPS of a novel sigma-1 receptor radiotracer [18F]2-Flouroethyl-[(4-cyanophenoxy)methyl]piperidine ([18F]WLS1.002)

2005 ◽  
Vol 25 (1_suppl) ◽  
pp. S597-S597
Author(s):  
Rikki N Waterhouse ◽  
Jun Zhao ◽  
Raymond C Chang ◽  
Patty Carambot
Keyword(s):  
In Vivo Evaluation ◽  
Sigma 1 Receptor ◽  
Sigma 1

[123I]TPCNE: A novel SPET tracer for the sigma-1 receptor binds irreversibly in humans in vivo

2005 ◽  
Vol 25 (1_suppl) ◽  
pp. S655-S655
Author(s):  
James M Stone ◽  
Erik Arstad ◽  
Kjell Erlandsson ◽  
Rikki N Waterhouse ◽  
Peter J Ell ◽  
...  
Keyword(s):  
Sigma 1 Receptor ◽  
Sigma 1

The activity of selective sigma-1 receptor ligands in seizure models in vivo

2017 ◽  
Vol 328 ◽  
pp. 13-18 ◽  
Author(s):  
Edijs Vavers ◽  
Baiba Svalbe ◽  
Lasma Lauberte ◽  
Ilmars Stonans ◽  
Ilga Misane ◽  
...  
Keyword(s):  
Receptor Ligands ◽  
Sigma 1 Receptor ◽  
Seizure Models ◽  
Sigma 1

[ 11 C]Raclopride binding was reduced in vivo by sigma 1 receptor ligand SA4503 in the mouse brain, while [ 11 C]SA4503 binding was not by raclopride

2001 ◽  
Vol 28 (7) ◽  
pp. 787-792 ◽  
Author(s):  
Kiichi Ishiwata ◽  
Tadayuki Kobayashi ◽  
Kazunori Kawamura ◽  
Kiyoshi Matsuno ◽  
Michio Senda
Keyword(s):  
Mouse Brain ◽  
Receptor Ligand ◽  
Sigma 1 Receptor ◽  
Sigma 1

scholarly journals N,N-dimethyltryptamine compound found in the hallucinogenic tea ayahuasca, regulates adult neurogenesis in vitro and in vivo

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Jose A. Morales-Garcia ◽  
Javier Calleja-Conde ◽  
Jose A. Lopez-Moreno ◽  
Sandra Alonso-Gil ◽  
Marina Sanz-SanCristobal ◽  
...  
Keyword(s):  
Adult Neurogenesis ◽  
Spatial Learning And Memory ◽  
South American ◽  
New Production ◽  
Sigma 1 Receptor ◽  
Neurogenic Niche ◽  
Sigma 1 ◽  
Functional Relevance

Abstract N,N-dimethyltryptamine (DMT) is a component of the ayahuasca brew traditionally used for ritual and therapeutic purposes across several South American countries. Here, we have examined, in vitro and vivo, the potential neurogenic effect of DMT. Our results demonstrate that DMT administration activates the main adult neurogenic niche, the subgranular zone of the dentate gyrus of the hippocampus, promoting newly generated neurons in the granular zone. Moreover, these mice performed better, compared to control non-treated animals, in memory tests, which suggest a functional relevance for the DMT-induced new production of neurons in the hippocampus. Interestingly, the neurogenic effect of DMT appears to involve signaling via sigma-1 receptor (S1R) activation since S1R antagonist blocked the neurogenic effect. Taken together, our results demonstrate that DMT treatment activates the subgranular neurogenic niche regulating the proliferation of neural stem cells, the migration of neuroblasts, and promoting the generation of new neurons in the hippocampus, therefore enhancing adult neurogenesis and improving spatial learning and memory tasks.

Fenfluramine modulates the anti-amnesic effects induced by sigma-1 receptor agonists and neuro(active)steroids in vivo

2022 ◽  
Vol 127 ◽  
pp. 108526
Author(s):  
Parthena Martin ◽  
Tangui Maurice ◽  
Arnold Gammaitoni ◽  
Gail Farfel ◽  
Brooks Boyd ◽  
...  
Keyword(s):  
Sigma 1 Receptor ◽  
Receptor Agonists ◽  
Sigma 1

scholarly journals In vitro and in vivo sigma 1 receptor imaging studies in different disease states

2020 ◽  
Author(s):  
Hebaalla Agha ◽  
Christopher R. McCurdy
Keyword(s):  
Clinical Trials ◽  
Molecular Imaging ◽  
Receptor Imaging ◽  
Imaging Studies ◽  
Sigma 1 Receptor ◽  
The Road ◽  
Disease States ◽  
Sigma 1

Molecular imaging studies have paved the road for the development of successful σ1R ligands currently in clinical trials.

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