A microfluidic 3D hepatocyte chip for drug toxicity testing

Lab on a Chip ◽  
2009 ◽  
Vol 9 (14) ◽  
pp. 2026 ◽  
Author(s):  
Yi-Chin Toh ◽  
Teck Chuan Lim ◽  
Dean Tai ◽  
Guangfa Xiao ◽  
Danny van Noort ◽  
...  
Keyword(s):  
Drug Toxicity ◽  
Toxicity Testing

scholarly journals An AC electrothermal self-circulating system with a minimalist process to construct a biomimetic liver lobule model for drug testing

RSC Advances ◽  
2018 ◽  
Vol 8 (65) ◽  
pp. 36987-36998 ◽  
Author(s):  
Shengli Mi ◽  
Baihan Li ◽  
Xiaoman Yi ◽  
Yuanyuan Xu ◽  
Zhichang Du ◽  
...  
Keyword(s):  
Drug Toxicity ◽  
Drug Testing ◽  
Low Cost ◽  
Toxicity Testing ◽  
Liver Lobule ◽  
On Chip

Liver-on-chip, due to its precision and low cost for constructing in vitro models, has tremendous potential for drug toxicity testing and pathological studies.

The PIT method: an automated in vitro technique for drug toxicity testing

1987 ◽  
Vol 5 (2) ◽  
pp. 161-165 ◽  
Author(s):  
Rob van Lambalgen ◽  
Peter Lelieveld
Keyword(s):  
Drug Toxicity ◽  
Toxicity Testing ◽  
In Vitro Technique

Boar spermatozoa successfully predict mitochondrial modes of toxicity: Implications for drug toxicity testing and the 3R principles

2015 ◽  
Vol 29 (3) ◽  
pp. 582-591 ◽  
Author(s):  
A. Vicente-Carrillo ◽  
I. Edebert ◽  
H. Garside ◽  
I. Cotgreave ◽  
R. Rigler ◽  
...  
Keyword(s):  
Drug Toxicity ◽  
Toxicity Testing ◽  
Boar Spermatozoa

3D spheroid culture of hESC/hiPSC-derived hepatocyte-like cells for drug toxicity testing

Biomaterials ◽  
2013 ◽  
Vol 34 (7) ◽  
pp. 1781-1789 ◽  
Author(s):  
Kazuo Takayama ◽  
Kenji Kawabata ◽  
Yasuhito Nagamoto ◽  
Keisuke Kishimoto ◽  
Katsuhisa Tashiro ◽  
...  
Keyword(s):  
Drug Toxicity ◽  
Toxicity Testing ◽  
Spheroid Culture

scholarly journals On chip two-photon metabolic imaging for drug toxicity testing

2017 ◽  
Vol 11 (3) ◽  
pp. 034108 ◽  
Author(s):  
Fang Yu ◽  
Shuangmu Zhuo ◽  
Yinghua Qu ◽  
Deepak Choudhury ◽  
Zhiping Wang ◽  
...  
Keyword(s):  
Drug Toxicity ◽  
Toxicity Testing ◽  
Metabolic Imaging ◽  
Two Photon ◽  
On Chip

scholarly journals Real-time imaging of oxidative and nitrosative stress in the liver of live animals for drug-toxicity testing

2014 ◽  
Vol 32 (4) ◽  
pp. 373-380 ◽  
Author(s):  
Adam J Shuhendler ◽  
Kanyi Pu ◽  
Lina Cui ◽  
Jack P Uetrecht ◽  
Jianghong Rao
Keyword(s):  
Real Time ◽  
Drug Toxicity ◽  
Nitrosative Stress ◽  
Toxicity Testing ◽  
Oxidative And Nitrosative Stress ◽  
Real Time Imaging

scholarly journals Is There a Space-Based Technology Solution to Problems with Preclinical Drug Toxicity Testing?

2016 ◽  
Vol 33 (7) ◽  
pp. 1545-1551 ◽  
Author(s):  
Timothy Hammond ◽  
Patricia Allen ◽  
Holly Birdsall
Keyword(s):  
Drug Toxicity ◽  
Toxicity Testing ◽  
Technology Solution
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