Using a Microfluidic Device for Culture and Drug Toxicity Testing of 3D Cells

2019 ◽  
pp. 235-241 ◽  
Author(s):  
Jonas Christoffersson ◽  
Carl-Fredrik Mandenius
Keyword(s):  
Microfluidic Device ◽  
Drug Toxicity ◽  
Toxicity Testing

scholarly journals An AC electrothermal self-circulating system with a minimalist process to construct a biomimetic liver lobule model for drug testing

RSC Advances ◽  
2018 ◽  
Vol 8 (65) ◽  
pp. 36987-36998 ◽  
Author(s):  
Shengli Mi ◽  
Baihan Li ◽  
Xiaoman Yi ◽  
Yuanyuan Xu ◽  
Zhichang Du ◽  
...  
Keyword(s):  
Drug Toxicity ◽  
Drug Testing ◽  
Low Cost ◽  
Toxicity Testing ◽  
Liver Lobule ◽  
On Chip

Liver-on-chip, due to its precision and low cost for constructing in vitro models, has tremendous potential for drug toxicity testing and pathological studies.

The PIT method: an automated in vitro technique for drug toxicity testing

1987 ◽  
Vol 5 (2) ◽  
pp. 161-165 ◽  
Author(s):  
Rob van Lambalgen ◽  
Peter Lelieveld
Keyword(s):  
Drug Toxicity ◽  
Toxicity Testing ◽  
In Vitro Technique

Boar spermatozoa successfully predict mitochondrial modes of toxicity: Implications for drug toxicity testing and the 3R principles

2015 ◽  
Vol 29 (3) ◽  
pp. 582-591 ◽  
Author(s):  
A. Vicente-Carrillo ◽  
I. Edebert ◽  
H. Garside ◽  
I. Cotgreave ◽  
R. Rigler ◽  
...  
Keyword(s):  
Drug Toxicity ◽  
Toxicity Testing ◽  
Boar Spermatozoa

3D spheroid culture of hESC/hiPSC-derived hepatocyte-like cells for drug toxicity testing

Biomaterials ◽  
2013 ◽  
Vol 34 (7) ◽  
pp. 1781-1789 ◽  
Author(s):  
Kazuo Takayama ◽  
Kenji Kawabata ◽  
Yasuhito Nagamoto ◽  
Keisuke Kishimoto ◽  
Katsuhisa Tashiro ◽  
...  
Keyword(s):  
Drug Toxicity ◽  
Toxicity Testing ◽  
Spheroid Culture

scholarly journals On chip two-photon metabolic imaging for drug toxicity testing

2017 ◽  
Vol 11 (3) ◽  
pp. 034108 ◽  
Author(s):  
Fang Yu ◽  
Shuangmu Zhuo ◽  
Yinghua Qu ◽  
Deepak Choudhury ◽  
Zhiping Wang ◽  
...  
Keyword(s):  
Drug Toxicity ◽  
Toxicity Testing ◽  
Metabolic Imaging ◽  
Two Photon ◽  
On Chip

scholarly journals Real-time imaging of oxidative and nitrosative stress in the liver of live animals for drug-toxicity testing

2014 ◽  
Vol 32 (4) ◽  
pp. 373-380 ◽  
Author(s):  
Adam J Shuhendler ◽  
Kanyi Pu ◽  
Lina Cui ◽  
Jack P Uetrecht ◽  
Jianghong Rao
Keyword(s):  
Real Time ◽  
Drug Toxicity ◽  
Nitrosative Stress ◽  
Toxicity Testing ◽  
Oxidative And Nitrosative Stress ◽  
Real Time Imaging

A microfluidic 3D hepatocyte chip for drug toxicity testing

Lab on a Chip ◽  
2009 ◽  
Vol 9 (14) ◽  
pp. 2026 ◽  
Author(s):  
Yi-Chin Toh ◽  
Teck Chuan Lim ◽  
Dean Tai ◽  
Guangfa Xiao ◽  
Danny van Noort ◽  
...  
Keyword(s):  
Drug Toxicity ◽  
Toxicity Testing

scholarly journals Transport Model for Microfluidic Device for Cell Culture and Tissue Development

2011 ◽  
Vol 1299 ◽  
Author(s):  
Niraj Inamdar ◽  
Linda Griffith ◽  
Jeffrey T. Borenstein
Keyword(s):  
Microfluidic Device ◽  
Single Channel ◽  
Transport Model ◽  
Toxicity Testing ◽  
Analytical Models ◽  
Critical Parameters ◽  
Shear Stresses ◽  
Flow Conditions ◽  
Soluble Factors ◽  
The Media

ABSTRACTIn recent years, microfluidic devices have emerged as a platform in which to culture tissue for various applications such as drug discovery, toxicity testing, and fundamental investigations of cell-cell interactions. We examine the transport phenomena associated with gradients of soluble factors and oxygen in a microfluidic device for co-culture. This work focuses on emulating conditions known to be important in sustaining a viable culture of cells. Critical parameters include the flow and the resulting shear stresses, the transport of various soluble factors throughout the flow media, and the mechanical arrangement of the cells in the device. Using analytical models derived from first principles, we investigate interactions between flow conditions and transport in a microfluidic device. A particular device of interest is a bilayer configuration in which critical solutes such as oxygen are delivered through the media into one channel, transported across a nanoporous membrane, and consumed by cells cultured in another. The ability to control the flow conditions in this membrane bilayer device to achieve sufficient oxygenation without shear damage is shown to be superior to the case present in a single channel system. Using the results of these analyses, a set of criteria that characterize the geometric and transport properties of a robust microfluidic device are provided.

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