Proteomic profiling and potential cellular target identification of K11777, a clinical cysteine protease inhibitor, in Trypanosoma brucei

2012 ◽  
Vol 48 (6) ◽  
pp. 835-837 ◽  
Author(s):  
Peng-Yu Yang ◽  
Min Wang ◽  
Cynthia Y. He ◽  
Shao Q. Yao
Keyword(s):  
Protease Inhibitor ◽  
Trypanosoma Brucei ◽  
Cysteine Protease ◽  
Target Identification ◽  
Cysteine Protease Inhibitor ◽  
Proteomic Profiling ◽  
Cellular Target

scholarly journals A Novel Cysteine Protease Inhibitor of Naegleria fowleri That Is Specifically Expressed during Encystation and at Mature Cysts

Pathogens ◽  
2021 ◽  
Vol 10 (4) ◽  
pp. 388
Author(s):  
Hương Giang Lê ◽  
A-Jeong Ham ◽  
Jung-Mi Kang ◽  
Tuấn Cường Võ ◽  
Haung Naw ◽  
...  
Keyword(s):  
Protease Inhibitor ◽  
Cysteine Protease ◽  
Expression Profiles ◽  
Critical Role ◽  
Cyst Formation ◽  
Cysteine Proteases ◽  
Cysteine Protease Inhibitor ◽  
Naegleria Fowleri ◽  
Nægleria Fowleri ◽  
Cystatin Family

Naegleria fowleri is a free-living amoeba that is ubiquitous in diverse natural environments. It causes a fatal brain infection in humans known as primary amoebic meningoencephalitis. Despite the medical importance of the parasitic disease, there is a great lack of knowledge about the biology and pathogenicity of N. fowleri. In this study, we identified and characterized a novel cysteine protease inhibitor of N. fowleri (NfCPI). NfCPI is a typical cysteine protease inhibitor belonging to the cystatin family with a Gln-Val-Val-Ala-Gly (QVVAG) motif, a characteristic motif conserved in the cystatin family of proteins. Bacterially expressed recombinant NfCPI has a dimeric structure and exhibits inhibitory activity against several cysteine proteases including cathespin Bs of N. fowleri at a broad range of pH values. Expression profiles of nfcpi revealed that the gene was highly expressed during encystation and cyst of the amoeba. Western blot and immunofluorescence assays also support its high level of expression in cysts. These findings collectively suggest that NfCPI may play a critical role in encystation or cyst formation of N. fowleri by regulating cysteine proteases that may mediate encystation or mature cyst formation of the amoeba. More comprehensive studies to investigate the roles of NfCPI in encystation and its target proteases are necessary to elucidate the regulatory mechanism and the biological significance of NfCPI.

Molecular Modeling in Cysteine Protease Inhibitor Design

2002 ◽  
Vol 8 (18) ◽  
pp. 1673-1681 ◽  
Author(s):  
Mika Lindvall
Keyword(s):  
Molecular Modeling ◽  
Protease Inhibitor ◽  
Cysteine Protease ◽  
Cysteine Protease Inhibitor ◽  
Inhibitor Design

A novel cysteine protease inhibitor with lectin activity from the epidermis of the Japanese eel Anguilla japonica

2005 ◽  
Vol 141 (1) ◽  
pp. 103-109 ◽  
Author(s):  
Eiichi Saitoh ◽  
Satoko Isemura ◽  
Akira Chiba ◽  
Shunya Oka ◽  
Shoji Odani
Keyword(s):  
Protease Inhibitor ◽  
Cysteine Protease ◽  
Anguilla Japonica ◽  
Japanese Eel ◽  
Cysteine Protease Inhibitor ◽  
Lectin Activity

Inhibition of amyloid-beta fibril formation and neurotoxicity by the cysteine protease inhibitor cystatin C

Neuropeptides ◽  
2006 ◽  
Vol 40 (6) ◽  
pp. 427-428
Author(s):  
E. Levy ◽  
W. Mi ◽  
B. Tizon ◽  
M. Pawlik
Keyword(s):  
Protease Inhibitor ◽  
Cystatin C ◽  
Amyloid Beta ◽  
Cysteine Protease ◽  
Fibril Formation ◽  
Cysteine Protease Inhibitor

Characterization of serine/cysteine protease inhibitor α1-antitripsin from meconium-instilled rabbit lungs

2005 ◽  
Vol 96 (1) ◽  
pp. 137-144 ◽  
Author(s):  
A.M. Zagariya ◽  
R. Bhat ◽  
E. Zhabotynsky ◽  
G. Chari ◽  
S. Navale ◽  
...  
Keyword(s):  
Protease Inhibitor ◽  
Cysteine Protease ◽  
Cysteine Protease Inhibitor

scholarly journals An animal model of the procognitive properties of cysteine protease inhibitor and immunomodulatory peptides based on colostrum.

2017 ◽  
Vol 26 (4) ◽  
pp. 563-569 ◽  
Author(s):  
Bartłomiej Stańczykiewicz ◽  
Marta Jakubik-Witkowska ◽  
Antoni Polanowski ◽  
Tadeusz Trziszka ◽  
Joanna Rymaszewska
Keyword(s):  
Animal Model ◽  
Protease Inhibitor ◽  
Cysteine Protease ◽  
Cysteine Protease Inhibitor ◽  
Immunomodulatory Peptides

ChemInform Abstract: Conformation of Ethyl (+)-(2S,3S)-3-(1-(N-(3-Methylbutyl)amino)leucylcarbonyl)oxirane-2-carboxylate (Loxistatin) (I), a Cysteine Protease Inhibitor: X-Ray Crystallographic and 1H NMR Studies

ChemInform ◽  
1988 ◽  
Vol 19 (40) ◽  
Author(s):  
T. ISHIDA ◽  
M. SAKAGUCHI ◽  
D. YAMAMOTO ◽  
M. INOUE ◽  
K. KITAMURA ◽  
...  
Keyword(s):  
Protease Inhibitor ◽  
1H Nmr ◽  
Cysteine Protease ◽  
Cysteine Protease Inhibitor ◽  
Nmr Studies ◽  
X Ray

scholarly journals Effect of phenyl vinyl sulphone cysteine protease inhibitor on Schistosoma mansoni: in vitro and in vivo experimental studies

2017 ◽  
Vol 41 (4) ◽  
pp. 1049-1058
Author(s):  
Manal Salah El-Din Mahmoud ◽  
Ayman Nabil Ibrahim ◽  
Abeer Fathy Badawy ◽  
Nourhan Mohamed Abdelmoniem
Keyword(s):  
Protease Inhibitor ◽  
Schistosoma Mansoni ◽  
Cysteine Protease ◽  
Experimental Studies ◽  
Cysteine Protease Inhibitor ◽  
Phenyl Vinyl
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