Segregated ordered lipid phases and protein-promoted membrane cohesivity are required for pulmonary surfactant films to stabilize and protect the respiratory surface

2013 ◽  
Vol 161 ◽  
pp. 535-548 ◽  
Author(s):  
Jorge Bernardino de la Serna ◽  
Rodolfo Vargas ◽  
Victoria Picardi ◽  
Antonio Cruz ◽  
Rocío Arranz ◽  
...  
Keyword(s):  
Pulmonary Surfactant ◽  
Respiratory Surface

scholarly journals Restoring pulmonary surfactant membranes and films at the respiratory surface

2017 ◽  
Vol 1859 (9) ◽  
pp. 1725-1739 ◽  
Author(s):  
Mercedes Echaide ◽  
Chiara Autilio ◽  
Raquel Arroyo ◽  
Jesus Perez-Gil
Keyword(s):  
Pulmonary Surfactant ◽  
Respiratory Surface

Pulmonary surfactant given prophylactically alleviates an asthma attack in guinea-pigs

1996 ◽  
Vol 26 (3) ◽  
pp. 270-275 ◽  
Author(s):  
M. LIU ◽  
L. WANG ◽  
E. LI ◽  
G. ENHORNING
Keyword(s):  
Guinea Pigs ◽  
Pulmonary Surfactant ◽  
Asthma Attack

Microflora of the respiratory surface of rodents exposed to "inert" particulates

1971 ◽  
Vol 127 (6) ◽  
pp. 1103-1104 ◽  
Author(s):  
M. C. Battigelli
Keyword(s):  
Respiratory Surface

Foreign Body Reaction to Exogenous Pulmonary Surfactant in an Infant with Hydrops and Cardiomyopathy

1996 ◽  
Vol 16 (1) ◽  
pp. 83-88
Author(s):  
Robert Bendon ◽  
Jim Greenberg ◽  
Sue Heffelfinger
Keyword(s):  
Foreign Body ◽  
Pulmonary Surfactant ◽  
Foreign Body Reaction

Screening and Identification of Aptamers Aganinst Pulmonary Surfactant Protein A

2013 ◽  
Vol 41 (11) ◽  
pp. 1659
Author(s):  
Li-Juan LIU ◽  
Yi CHEN ◽  
Wei WANG ◽  
Chao CHEN ◽  
Ming-Hao GAO ◽  
...  
Keyword(s):  
Pulmonary Surfactant ◽  
Protein A ◽  
Surfactant Protein ◽  
Surfactant Protein A ◽  
Screening And Identification ◽  
Pulmonary Surfactant Protein

Possible benefits of reformulating antiviral drugs with nanoemulsion system in the treatment of novel coronavirus infection

Coronaviruses ◽  
2020 ◽  
Vol 01 ◽  
Author(s):  
Manish Kumar ◽  
Chandra Prakash Jain
Keyword(s):  
Drug Delivery ◽  
Drug Therapy ◽  
Pulmonary Surfactant ◽  
Antiviral Drug ◽  
Treatment Strategies ◽  
Drug Dosage ◽  
Antiviral Drugs ◽  
Antiviral Action ◽  
Coronavirus Infection ◽  
Novel Coronavirus

Background: An outbreak of SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) infection or COVID 19, causing serious threats to all around the world. Until an effective and safe vaccine for novel coronavirus is developed by scientists, current drug therapy should by optimize for the control and treatment of COVID 19. Objective: In this manuscript, we are presenting a perspective on possible benefits of reformulating antiviral drug dosage form with nanoemulsion system against novel coronavirus infection. Methods: Literature review has been done on COVID 19, treatment strategies, novel drug delivery systems and role of pulmonary surfactant on lungs protection. Results: Nanoemulsion system and its components have certain biophysical properties which could increase the efficacy of drug therapy. Antiviral drugs, delivered through a nanoemulsion system containing P-gp inhibitor (surfactant and cosolvent), can inhibit the cellular resistance to drugs and would potentiate the antiviral action of drugs. Pulmonary surfactant (PS) assisted antiviral drug delivery by nanoemulsion system could be another effective approach for the treatment of COVID 19. Use of functional excipients like pulmonary surfactant (PS) and surfactant proteins (SPs), in the formulation of the antiviral drug-loaded nanoemulsion system can improve the treatment of coronavirus infection. Conclusion: In our opinion for synergizing antiviral action, lipid and protein portion of PS and their commercial analogs should be explored by pharmaceutical scientists to use them as a functional excipient in the formulation of antiviral drugloaded nanoemulsion system.

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