Recent developments and applications of saturation transfer difference nuclear magnetic resonance (STD NMR) spectroscopy

2013 ◽  
Vol 9 (4) ◽  
pp. 571-577 ◽  
Author(s):  
Jane L. Wagstaff ◽  
Samantha L. Taylor ◽  
Mark J. Howard
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Nmr Spectroscopy ◽  
Magnetic Resonance ◽  
Saturation Transfer ◽  
Saturation Transfer Difference ◽  
Recent Developments ◽  
Std Nmr ◽  
Nuclear Magnetic

Comparison of binding properties of a novel non-steroidal anti-inflammatory agent and ibuprofen to cyclooxygenase-1 and cyclooxygenase-2 enzymes by saturation transfer difference nuclear magnetic resonance

2018 ◽  
Vol 96 (7) ◽  
pp. 693-699
Author(s):  
Nil E. Binbay ◽  
Berrin Ziyadanogullari
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Cyclooxygenase 2 ◽  
Saturation Transfer ◽  
Inflammatory Agent ◽  
Saturation Transfer Difference ◽  
Cyclooxygenase 1 ◽  
Anti Inflammatory ◽  
Novel Agent ◽  
Nuclear Magnetic

Saturation transfer difference nuclear magnetic resonance is a ligand-based screening technique that focuses directly on the physical interaction of a macromolecule (protein, enzyme, etc.) and a small ligand. It is a powerful tool in pharmaceutical research. Here, a comparison is reported of the binding characteristics of ibuprofen and a novel anti-inflammatory agent to cyclooxygenase-1 and cyclooxygenase-2 enzymes as an application of saturation transfer difference nuclear magnetic resonance. It has been shown that this novel agent is capable of binding to both isoforms of the cyclooxygenase enzymes. It has also been reported that novel agent binds better to cyclooxygenase-2.

scholarly journals Saturation transfer difference nuclear magnetic resonance titrations reveal complex multistep-binding of l-fucose to norovirus particles

Glycobiology ◽  
2016 ◽  
Vol 27 (1) ◽  
pp. 80-86 ◽  
Author(s):  
Alvaro Mallagaray ◽  
Christoph Rademacher ◽  
Francisco Parra ◽  
Grant Hansman ◽  
Thomas Peters
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Saturation Transfer ◽  
Saturation Transfer Difference ◽  
Nuclear Magnetic
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