Inter- and intra-molecular condensations of CN–and NH2–with co-ordinated acetonitrile: an amino acid synthesis. X-Ray crystal structure of [(NH3)3Co{(Me)C(NH2)(NH2CNH2)2}]Br3·2/3H2O
α-Amino acids find widespread applications in various areas of life and physical sciences. Their syntheses are carried out by a multitude of protocols, of which Petasis and Strecker reactions have emerged as the most straightforward and most widely used. Both reactions are three-component reactions using the same starting materials, except the nucleophilic species. The differences and similarities between these two important reactions are highlighted in this review.
Petasis vs. Strecker Amino Acid Synthesis: Convergence, Divergence and Opportunities in Organic Synthesis