Biomedical Applications of Iron Oxide Nanoparticles: Current Insights Progress and Perspectives

The enormous development of nanomaterials technology and the immediate response of many areas of science, research, and practice to their possible application has led to the publication of thousands of scientific papers, books, and reports. This vast amount of information requires careful classification and order, especially for specifically targeted practical needs. Therefore, the present review aims to summarize to some extent the role of iron oxide nanoparticles in biomedical research. Summarizing the fundamental properties of the magnetic iron oxide nanoparticles, the review’s next focus was to classify research studies related to applying these particles for cancer diagnostics and therapy (similar to photothermal therapy, hyperthermia), in nano theranostics, multimodal therapy. Special attention is paid to research studies dealing with the opportunities of combining different nanomaterials to achieve optimal systems for biomedical application. In this regard, original data about the synthesis and characterization of nanolipidic magnetic hybrid systems are included as an example. The last section of the review is dedicated to the capacities of magnetite-based magnetic nanoparticles for the management of oncological diseases.

Synthesis of Ti-Al-xNb Ternary Alloys via Laser-Engineered Net Shaping for Biomedical Application: Densification, Electrochemical and Mechanical Properties Studies

The lives of many people around the world are impaired and shortened mostly by cardiovascular diseases (CVD). Despite the fact that medical interventions and surgical heart transplants may improve the lives of patients suffering from cardiovascular disease, the cost of treatments and securing a perfect donor are aspects that compel patients to consider cheaper and less invasive therapies. The use of synthetic biomaterials such as titanium-based implants are an alternative for cardiac repair and regeneration. In this work, an in situ development of Ti-Al-xNb alloys were synthesized via laser additive manufacturing for biomedical application. The effect of Nb composition on Ti-Al was investigated. The microstructural evolution was characterized using a scanning electron microscope (SEM) equipped with energy dispersive spectroscopy (EDS). A potentiodynamic polarization technique was utilized to investigate the corrosion behavior of TiAl-Nb in 3.5% NaCl. The microhardness and corrosion behaviour of the synthesized Ti-Al-Nb alloys were found to be dependent on laser-processing parameters. The microhardness performance of the samples increased with an increase in the Nb feed rate to the Ti-Al alloy system. Maximum microhardness of 699.8 HVN was evident at 0.061 g/min while at 0.041 g/min the microhardness was 515.8 HVN at Nb gas carrier of 1L/min, respectively.

Coordination-assembled Nanoarchitectonics of Antioxidant Peptide and Flavonoid Myricetin for Sustainably Scavenging Free Radicals

Oxidative stress can lead to permanent and irreversible damage for cellular components, and even cause cancer and many diseases. Therefore, the development of antioxidative reagents is a significant strategy for alleviating chronic diseases and maintaining the redox balance. Small-molecule bioactive compounds have exhibited huge therapeutic potential in antioxidant and anti-inflammatory. Myricetin (Myr) as well-defined natural flavonoid, has drawn wide attention on highly effective antioxidant, anti-inflammatory, antimicrobial, and anticancer activities. Especially at antioxidation, Myr is capable of not only chelating intracellular transition metal ions for removing reactive oxygen species (ROS), but also activating antioxidant enzymes and related signal, achieving sustainable scavenging radical activity. However, Myr possesses poor water solubility, which limits its bioavailability for biomedical application, even clinical therapeutic potential. The endogenous antioxidant peptide glutathione (GSH) plays a direct role on antioxidant in cells and possesses good hydrophilicity and biocompatibility, but is easily metabolized by enzyme. To take advantages of their antioxidation activity and overcome the above-mentioned limitations, the GSH, Zn2+ and Myr are selected to co-assemble into Myr-Zn2+-GSH (abbreviated as MZG nanoparticles or nanoarchitectonics). Thence, this study offers a new design to harness stable, sustainable antioxidant nanoparticles with high loading capacity and bioavailability, good biocompatibility for optimizing antioxidant to protect cells from oxygenated damage.

Physical and Mechanical Properties of Tilapia Scale Hydroxyapatite-Filled High-Density Polyethylene Composites

The effects of filler loading and silane coupling agent on the properties of hydroxyapatite (HAp)-filled high density polyethylene (HDPE) composites have been studied. The (HAp) powder was successfully produced from tilapia scales using the spray drying process utilized to prepare the HDPE/HAp composites. The FTIR peaks for the untreated HDPE/30HAp composite corresponded to the functional groups of HDPE (C-CH3) and –CH2 and HAp (PO4−3 and O-H). The FTIR spectrum for the silane-treated composite showed that the C=O and silanol groups were eliminated, which strongly confirms the chemical interaction between the HAp fillers and the HDPE matrix. The developed composites demonstrated enhanced mechanical performance, and in particular the treated HDPE/30HAp-S composite exhibited superior tensile strength, Young’s modulus and flexural modulus of 28.26 MPa, 1272 MPa and 796 MPa, respectively. In vitro cytotoxicity analysis showed that the developed composites were non-toxic and have great potential to be used for biomedical application.

Recent Advances in Zwitterionic Hydrogels: Preparation, Property, and Biomedical Application

Nonspecific protein adsorption impedes the sustainability of materials in biologically related applications. Such adsorption activates the immune system by quick identification of allogeneic materials and triggers a rejection, resulting in the rapid failure of implant materials and drugs. Antifouling materials have been rapidly developed in the past 20 years, from natural polysaccharides (such as dextran) to synthetic polymers (such as polyethylene glycol, PEG). However, recent studies have shown that traditional antifouling materials, including PEG, still fail to overcome the challenges of a complex human environment. Zwitterionic materials are a class of materials that contain both cationic and anionic groups, with their overall charge being neutral. Compared with PEG materials, zwitterionic materials have much stronger hydration, which is considered the most important factor for antifouling. Among zwitterionic materials, zwitterionic hydrogels have excellent structural stability and controllable regulation capabilities for various biomedical scenarios. Here, we first describe the mechanism and structure of zwitterionic materials. Following the preparation and property of zwitterionic hydrogels, recent advances in zwitterionic hydrogels in various biomedical applications are reviewed.

Synthesis, Characterization and Biomedical Application of Silver Nanoparticles

Silver nanoparticles (AgNPs) have been employed in various fields of biotechnology due to their proven properties as an antibacterial, antiviral and antifungal agent. AgNPs are generally synthesized through chemical, physical and biological approaches involving a myriad of methods. As each approach confers unique advantages and challenges, a trends analysis of literature for the AgNPs synthesis using different types of synthesis were also reviewed through a bibliometric approach. A sum of 10,278 publications were analyzed on the annual numbers of publication relating to AgNPs and biological, chemical or physical synthesis from 2010 to 2020 using Microsoft Excel applied to the Scopus publication database. Furthermore, another bibliometric clustering and mapping software were used to study the occurrences of author keywords on the biomedical applications of biosynthesized AgNPs and a total collection of 224 documents were found, sourced from articles, reviews, book chapters, conference papers and reviews. AgNPs provides an excellent, dependable, and effective solution for seven major concerns: as antibacterial, antiviral, anticancer, bone healing, bone cement, dental applications and wound healing. In recent years, AgNPs have been employed in biomedical sector due to their antibacterial, antiviral and anticancer properties. This review discussed on the types of synthesis, how AgNPs are characterized and their applications in biomedical field.

Nanomedicine-enabled chemotherapy-based synergetic cancer treatments

Chemotherapy remains one of the most prevailing regimens hitherto in the fight against cancer, but its development has been being suffering from various fatal side effects associated with the non-specific toxicity of common chemical drugs. Advances in biomedical application of nanomedicine have been providing alternative but promising approaches for cancer therapy, by leveraging its excellent intrinsic physicochemical properties to address these critical concerns. In particular, nanomedicine-enabled chemotherapy has been established as a safer and promising therapeutic modality, especially the recently proposed nanocatalytic medicine featuring the capabilities to generate toxic substances by initiating diverse catalytic reactions within the tumor without directly relying on highly toxic but non-selective chemotherapeutic agents. Of special note, under exogenous/endogenous stimulations, nanomedicine can serve as a versatile platform that allows additional therapeutic modalities (photothermal therapy (PTT), photodynamic therapy (PDT), chemodynamic therapy (CDT), etc.) to be seamlessly integrated with chemotherapy for efficacious synergistic treatments of tumors. Here, we comprehensively review and summarize the representative studies of multimodal synergistic cancer treatments derived from nanomedicine and nanocatalytic medicine-enabled chemotherapy in recent years, and their underlying mechanisms are also presented in detail. A number of existing challenges and further perspectives for nanomedicine-synergized chemotherapy for malignant solid tumor treatments are also highlighted for understanding this booming research area as comprehensively as possible. Graphical Abstract

Aptamer-Enabled Nanomaterials for Therapeutics, Drug Targeting and Imaging

A wide variety of nanomaterials have emerged in recent years with advantageous properties for a plethora of therapeutic and diagnostic applications. Such applications include drug delivery, imaging, anti-cancer therapy and radiotherapy. There is a critical need for further components which can facilitate therapeutic targeting, augment their physicochemical properties, or broaden their theranostic applications. Aptamers are single-stranded nucleic acids which have been selected or evolved to bind specifically to molecules, surfaces, or cells. Aptamers can also act as direct biologic therapeutics, or in imaging and diagnostics. There is a rich field of discovery at the interdisciplinary interface between nanomaterials and aptamer science that has significant potential across biomedicine. Herein, we review recent progress in aptamer-enabled materials and discuss pending challenges for their future biomedical application.

Analysis and Comparison of Electromagnetic Microrobotic Platforms for Biomedical Applications

Magnetic microrobotics is a promising technology for improving minimally invasive surgery (MIS) with the ambition of enhancing patient care and comfort. The potential benefits include limited incisions, less hemorrhaging and postoperative pain, and faster recovery time. To achieve this, a key issue relies on the design of a proper electromagnetic actuation (EMA) setup which is based on the use of magnetic sources. The magnetic field and its gradient generated by the EMA platform is then used to induce magnetic torque and force for microrobot manipulations inside the human body. Like any control systems, the EMA system must be adapted to the given controlled microrobot and customized for the application. With great research efforts on magnetic manipulating of microrobots, the EMA systems are approaching commercial applications, and their configurations are becoming more suitable to be employed in real medical surgeries. However, most of the proposed designs have not followed any specific rule allowing to take into account the biomedical applications constraints. Through reviewing the different proposed EMA systems in the literature, their various specifications and configurations are comprehensively discussed and analyzed. This study focus on EMA platforms that use electromagnets. From this review and based on the biomedical application specifications, the appropriate EMA system can be determined efficiently.