scholarly journals A critical assessment of the photodegradation of pharmaceuticals in aquatic environments: defining our current understanding and identifying knowledge gaps

2014 ◽  
Vol 16 (4) ◽  
pp. 672 ◽  
Author(s):  
Jonathan K. Challis ◽  
Mark L. Hanson ◽  
Ken J. Friesen ◽  
Charles S. Wong
Author(s):  
Julie Roux ◽  
Maissa Zeghidi ◽  
Stephanie Villar ◽  
Zisis Kozlakidis

BJR|Open ◽  
2020 ◽  
Vol 2 (1) ◽  
pp. 20190020 ◽  
Author(s):  
Keshav Shree Mudgal ◽  
Neelanjan Das

Artificial intelligence (AI) is rapidly transforming healthcare—with radiology at the pioneering forefront. To be trustfully adopted, AI needs to be lawful, ethical and robust. This article covers the different aspects of a safe and sustainable deployment of AI in radiology during: training, integration and regulation. For training, data must be appropriately valued, and deals with AI companies must be centralized. Companies must clearly define anonymization and consent, and patients must be well-informed about their data usage. Data fed into algorithms must be made AI-ready by refining, purification, digitization and centralization. Finally, data must represent various demographics. AI needs to be safely integrated with radiologists-in-the-loop: guiding forming concepts of AI solutions and supervising training and feedback. To be well-regulated, AI systems must be approved by a health authority and agreements must be made upon liability for errors, roles of supervised and unsupervised AI and fair workforce distribution (between AI and radiologists), with a renewal of policy at regular intervals. Any errors made must have a root-cause analysis, with outcomes fedback to companies to close the loop—thus enabling a dynamic best prediction system. In the distant future, AI may act autonomously with little human supervision. Ethical training and integration can ensure a "transparent" technology that will allow insight: helping us reflect on our current understanding of imaging interpretation and fill knowledge gaps, eventually moulding radiological practice. This article proposes recommendations for ethical practise that can guide a nationalized framework to build a sustainable and transparent system.


2010 ◽  
Vol 213 (6) ◽  
pp. 894-900 ◽  
Author(s):  
S. K. Wilson ◽  
M. Adjeroud ◽  
D. R. Bellwood ◽  
M. L. Berumen ◽  
D. Booth ◽  
...  

Nano LIFE ◽  
2014 ◽  
Vol 04 (01) ◽  
pp. 1440004 ◽  
Author(s):  
Yun Zhao ◽  
Kee Woei Ng

Nanotoxicology is a concern. While skin exposure is generally perceived as less hazardous than inhalation or ingestion of engineered nanoparticles, there remain significant knowledge gaps in the topic to suggest greater caution in making a conclusion. Penetration of nanoparticles across an intact skin barrier is low. However, the verdict is still out on how this will change in situations where the skin barrier is compromised. Many studies on the interaction of nanoparticles with biological systems including skin cells have been reported. Under different scenarios, nanoparticles commonly found in topical skin products have been shown to be capable of exerting a variety of toxicological influences. These influences include causing cell death, stress, inflammation and damage to DNA. While alarming, it should also be noted that there remains much confusion and contradiction in the literature due to the complexity of studying cell–nanoparticle interactions. This review aims to provide a concise perspective on our current understanding of nanotoxicology in the skin, and identify the knowledge gaps where research efforts may be focused to help clarify the uncertainties in the field.


2015 ◽  
Vol 76 ◽  
pp. 130-146 ◽  
Author(s):  
Farshad Rajabipour ◽  
Eric Giannini ◽  
Cyrille Dunant ◽  
Jason H. Ideker ◽  
Michael D.A. Thomas

2020 ◽  
Vol 136 ◽  
pp. 105464 ◽  
Author(s):  
Katie Wan Yee Yeung ◽  
Guang-Jie Zhou ◽  
Klára Hilscherová ◽  
John P. Giesy ◽  
Kenneth Mei Yee Leung

2016 ◽  
Vol 3 (5) ◽  
pp. 966-981 ◽  
Author(s):  
Stine Rosendal Tangaa ◽  
Henriette Selck ◽  
Margrethe Winther-Nielsen ◽  
Farhan R. Khan

We review trophic transfer of metal-based nanoparticles in aquatic ecosystems, present key factors affecting this transfer and highlight knowledge gaps.


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