The effect of LNA nucleobases as enhancers for the binding of amiloride to an abasic site in DNA/DNA and DNA/RNA duplexes

2014 ◽  
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Tetsushi Sato ◽  
Takaya Sato ◽  
Seiichi Nishizawa ◽  
Norio Teramae

We report on a significant effect of locked nucleic acid (LNA) nucleobases on the binding of amiloride for abasic site (AP)-containing DNA duplexes.

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