The discovery and characterization of a novel scaffold as a potent hepatitis C virus inhibitor

2016 ◽  
Vol 52 (16) ◽  
pp. 3340-3343 ◽  
Author(s):  
Na Liu ◽  
Shiping Zhu ◽  
Xianghua Zhang ◽  
Xunkui Yin ◽  
Guoqiang Dong ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Structural Optimization ◽  
Phenotypic Screening ◽  
Virus Inhibitor ◽  
Target Characterization ◽  
Novel Scaffold

A novel anti-HCV benzothiazole scaffold was discovered by phenotypic screening. Further target characterization and structural optimization led to the identification of potent anti-HCV molecules targeting NS5A.

Discovery and characterization of a novel 7-aminopyrazolo[1,5-a]pyrimidine analog as a potent hepatitis C virus inhibitor

2012 ◽  
Vol 22 (24) ◽  
pp. 7297-7301 ◽  
Author(s):  
Jong Yeon Hwang ◽  
Marc Peter Windisch ◽  
Suyeon Jo ◽  
Keumhyun Kim ◽  
Sunju Kong ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Inhibitor ◽  
Pyrimidine Analog

scholarly journals Characterization of a hepatitis C virus genotype 1 divergent isolate from an HIV-1 coinfected individual in Germany assigned to a new subtype 1o

2019 ◽  
Vol 16 (1) ◽  
Author(s):  
Bo Wang ◽  
Luise Krüger ◽  
Patrycja Machnowska ◽  
Amare Eshetu ◽  
Barbara Gunsenheimer-Bartmeyer ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Genotype 1 ◽  
Virus Genotype ◽  
Hiv 1

scholarly journals Characterization of Resistance to Non-obligate Chain-terminating Ribonucleoside Analogs That Inhibit Hepatitis C Virus Replicationin Vitro

2003 ◽  
Vol 278 (49) ◽  
pp. 49164-49170 ◽  
Author(s):  
Giovanni Migliaccio ◽  
Joanne E. Tomassini ◽  
Steven S. Carroll ◽  
Licia Tomei ◽  
Sergio Altamura ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C

Characterization of mimotopes mimicking an immunodominant conformational epitope on the hepatitis C virus NS3 helicase

2004 ◽  
Vol 72 (3) ◽  
pp. 385-395 ◽  
Author(s):  
Colette Jolivet-Reynaud ◽  
Anne Adida ◽  
Sandrine Michel ◽  
Gilbert Deléage ◽  
Glaucia Paranhos-Baccala ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Conformational Epitope

scholarly journals Clinico-pathological characterization of hepatitis C virus-related B-cell non-Hodgkin’s lymphomas without symptomatic cryoglobulinemia

1998 ◽  
Vol 9 (5) ◽  
pp. 495-498 ◽  
Author(s):  
M. Luppi ◽  
G. Longo ◽  
M.G. Ferrari ◽  
P. Barozzi ◽  
R. Marasca ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
B Cell ◽  
Hodgkin's Lymphomas

Ultrastructural and physicochemical characterization of the hepatitis C virus recovered from the serum of an agammaglobulinemic patient

1998 ◽  
Vol 143 (11) ◽  
pp. 2241-2245 ◽  
Author(s):  
A. Trestard ◽  
Y. Bacq ◽  
L. Buzelay ◽  
F. Dubois ◽  
F. Barin ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Physicochemical Characterization

Characterization of clinical predictors of naturally occurring NS3/NS4A protease polymorphism in genotype 1 hepatitis C virus mono and HIV co-infected patients

2017 ◽  
Vol 89 (12) ◽  
pp. 2249-2254 ◽  
Author(s):  
Gaspar Lisboa Neto ◽  
Fernanda M. Malta ◽  
Michele S. Gomes-Gouvêa ◽  
Caroline F. Noble ◽  
Camila M. Romano ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Genotype 1 ◽  
Clinical Predictors ◽  
Naturally Occurring
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