Characterization of clinical predictors of naturally occurring NS3/NS4A protease polymorphism in genotype 1 hepatitis C virus mono and HIV co-infected patients

2017 ◽  
Vol 89 (12) ◽  
pp. 2249-2254 ◽  
Author(s):  
Gaspar Lisboa Neto ◽  
Fernanda M. Malta ◽  
Michele S. Gomes-Gouvêa ◽  
Caroline F. Noble ◽  
Camila M. Romano ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Genotype 1 ◽  
Clinical Predictors ◽  
Naturally Occurring

P0911 : Characterization of clinical predictors of naturally occurring NS3/NS4A protease polymorphism in genotype 1 Hepatitis C virus infected patients

2015 ◽  
Vol 62 ◽  
pp. S686
Author(s):  
G. Lisboa Neto ◽  
C. Noble ◽  
J.R.R. Pinho ◽  
F.M. Malta ◽  
M.S. Gomes-Gouvêa ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Genotype 1 ◽  
Clinical Predictors ◽  
Naturally Occurring

scholarly journals Characterization of a hepatitis C virus genotype 1 divergent isolate from an HIV-1 coinfected individual in Germany assigned to a new subtype 1o

2019 ◽  
Vol 16 (1) ◽  
Author(s):  
Bo Wang ◽  
Luise Krüger ◽  
Patrycja Machnowska ◽  
Amare Eshetu ◽  
Barbara Gunsenheimer-Bartmeyer ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Genotype 1 ◽  
Virus Genotype ◽  
Hiv 1

Characterization of vaniprevir, a hepatitis C virus NS3/4A protease inhibitor, in patients with HCV genotype 1 infection: Safety, antiviral activity, resistance, and pharmacokinetics

2013 ◽  
Vol 99 (3) ◽  
pp. 214-220 ◽  
Author(s):  
Eric Lawitz ◽  
Mark Sulkowski ◽  
Ira Jacobson ◽  
Walter K. Kraft ◽  
Benedict Maliakkal ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Antiviral Activity ◽  
Protease Inhibitor ◽  
Genotype 1 ◽  
Hcv Genotype ◽  
Hcv Genotype 1

scholarly journals Erratum for Mokhtari et al., Characterization of Samples Identified as Hepatitis C Virus Genotype 1 without Subtype by Abbott RealTime HCV Genotype II Assay Using the New Abbott HCV GenotypePlusRUO Test

2016 ◽  
Vol 54 (9) ◽  
pp. 2402-2402
Author(s):  
Camelia Mokhtari ◽  
Anne Ebel ◽  
Birgit Reinhardt ◽  
Sandra Merlin ◽  
Stéphanie Proust ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Genotype 1 ◽  
Virus Genotype ◽  
Hcv Genotype ◽  
Genotype Ii

scholarly journals Pretreatment Hepatitis C Virus NS5A/NS5B Resistance-Associated Substitutions in Genotype 1 Uruguayan Infected Patients

2018 ◽  
Vol 2018 ◽  
pp. 1-9 ◽  
Author(s):  
Fabián Aldunate ◽  
Natalia Echeverría ◽  
Daniela Chiodi ◽  
Pablo López ◽  
Adriana Sánchez-Cicerón ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Antiviral Agents ◽  
South American ◽  
Genotype 1 ◽  
Direct Acting Antiviral ◽  
Naturally Occurring ◽  
Before And After ◽  
Treatment Naïve ◽  
Direct Acting

Hepatitis C Virus (HCV) infection treatment has dramatically changed with the advent of direct-acting antiviral agents (DAAs). However, the efficacy of DAAs can be attenuated by the presence of resistance-associated substitutions (RASs) before and after treatment. Indeed, RASs detected in DAA treatment-naïve HCV-infected patients could be useful for clinical management and outcome prediction. Although the frequency of naturally occurring HCV NS5A and NS5B RASs has been addressed in many countries, there are only a few reports on their prevalence in the South American region. The aim of this study was to investigate the presence of RASs to NS5A and NS5B inhibitors in a DAA treatment naïve cohort of Uruguayan patients infected with chronic hepatitis C and compare them with reports from other South American countries. Here, we found that naturally occurring substitutions conferring resistance to NS5A and NS5B inhibitors were present in 8% and 19.2%, respectively, of treatment-naïve HCV genotype 1 infected patients. Importantly, the baseline substitutions in NS5A and NS5B herein identified differ from the studies previously reported in Brazil. Furthermore, Uruguayan strains subtype 1a clustered within all major world clades, showing that HCV variants currently circulating in this country are characterized by a remarkable genetic diversity.

scholarly journals Characterization of Samples Identified as Hepatitis C Virus Genotype 1 without Subtype by Abbott RealTime HCV Genotype II Assay Using the New Abbott HCV GenotypePlusRUO Test

2015 ◽  
Vol 54 (2) ◽  
pp. 296-299 ◽  
Author(s):  
Camelia Mokhtari ◽  
Anne Ebel ◽  
Birgit Reinhardt ◽  
Sandra Merlin ◽  
Stéphanie Proust ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Core Region ◽  
Genotype 1 ◽  
Virus Genotype ◽  
Hcv Genotype ◽  
The Core ◽  
Hcv Genotyping ◽  
Genotype Ii

Hepatitis C virus (HCV) genotyping continues to be relevant for therapeutic strategies. Some samples are reported as genotype 1 (gt 1) without subtype by the Abbott RealTime HCV Genotype II (GT II) test. To characterize such samples further, the Abbott HCV GenotypePlusRUO (Plus) assay, which targets the core region for gt 1a, gt 1b, and gt 6 detection, was evaluated as a reflex test in reference to NS5B or 5′-untranslated region (UTR)/core region sequencing. Of 3,626 routine samples, results of gt 1 without subtype were received for 171 samples (4.7%), accounting for 11.5% of gt 1 specimens. The Plus assay and sequencing were applied to 98 of those samples. NS5B or 5′-UTR/core region sequencing was successful for 91/98 specimens (92.9%). Plus assay and sequencing results were concordant for 87.9% of specimens (80/91 samples). Sequencing confirmed Plus assay results for 82.6%, 85.7%, 100%, and 89.3% of gt 1a, gt 1b, gt 6, and non-gt 1a/1b/6 results, respectively. Notably, 12 gt 6 samples that had been identified previously as gt 1 without subtype were assigned correctly here; for 25/28 samples reported as “not detected” by the Plus assay, sequencing identified the samples as gt 1 with subtypes other than 1a/1b. The genetic variability of HCV continues to present challenges for the current genotyping platforms regardless of the applied methodology. Samples identified by the GT II assay as gt 1 without subtype can be further resolved and reliably characterized by the new Plus assay.

Naturally occurring NS3 resistance-associated variants in hepatitis C virus genotype 1: Their relevance for developing countries

2016 ◽  
Vol 223 ◽  
pp. 140-146 ◽  
Author(s):  
Natalia Echeverría ◽  
Gabriela Betancour ◽  
Fabiana Gámbaro ◽  
Nelia Hernández ◽  
Pablo López ◽  
...  
Keyword(s):  
Developing Countries ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Genotype 1 ◽  
Virus Genotype ◽  
Naturally Occurring

scholarly journals Production and characterization of high-titer serum-free cell culture grown hepatitis C virus particles of genotype 1–6

Virology ◽  
2014 ◽  
Vol 458-459 ◽  
pp. 190-208 ◽  
Author(s):  
Christian K. Mathiesen ◽  
Tanja B. Jensen ◽  
Jannick Prentoe ◽  
Henrik Krarup ◽  
Alfredo Nicosia ◽  
...  
Keyword(s):  
Cell Culture ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
High Titer ◽  
Free Cell ◽  
Genotype 1 ◽  
Serum Free ◽  
Virus Particles
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