Synthesis and biological evaluation of 4′-[(benzimidazol-1-yl) methyl]biphenyl-2-amides as dual angiotensin II and endothelin A receptor antagonists

MedChemComm ◽  
2015 ◽  
Vol 6 (8) ◽  
pp. 1479-1483 ◽  
Author(s):  
Xiao-Feng Han ◽  
Wei-Zhe Xue ◽  
Li-Ping Hao ◽  
Zhi-Ming Zhou
Keyword(s):  
Angiotensin Ii ◽  
Biological Evaluation ◽  
The Novel ◽  
Receptor Antagonists ◽  
Endothelin A Receptor ◽  
Endothelin A ◽  
Synthesis And Biological Evaluation ◽  
Amide Fragment

Discovery of new benzimidazoles as potent dual AT1 and ETA receptor antagonists with the novel N-(1H-tetrazol-5-yl)-amide fragment.

Design, synthesis and biological activity of 4′-[(benzimidazol-1-yl)methyl]biphenyl-2-sulphonamides as dual angiotensin II and endothelin A receptor antagonists

MedChemComm ◽  
2015 ◽  
Vol 6 (4) ◽  
pp. 715-718 ◽  
Author(s):  
Li-Ping Hao ◽  
Wei-Zhe Xue ◽  
Xiao-Feng Han ◽  
Xing He ◽  
Jun Zhang ◽  
...  
Keyword(s):  
Biological Activity ◽  
Angiotensin Ii ◽  
Model Simulation ◽  
Molecular Model ◽  
Pharmacophore Model ◽  
Receptor Antagonists ◽  
Design Synthesis ◽  
3D Pharmacophore ◽  
Endothelin A Receptor ◽  
Endothelin A

A series of novel 4′-[(benzimidazol-1-yl)methyl]biphenyl-2-sulphonamides was designed, and their molecular model simulation fitting to a new HipHop 3D pharmacophore model was examined.

Discovery ofN-Isoxazolyl Biphenylsulfonamides as Potent Dual Angiotensin II and Endothelin A Receptor Antagonists

2002 ◽  
Vol 45 (18) ◽  
pp. 3829-3835 ◽  
Author(s):  
Natesan Murugesan ◽  
John E. Tellew ◽  
Zhengxiang Gu ◽  
Bridgette L. Kunst ◽  
Leena Fadnis ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Receptor Antagonists ◽  
Endothelin A Receptor ◽  
Endothelin A

Dual Angiotensin II and Endothelin A Receptor Antagonists:  Synthesis of 2‘-Substituted N-3-Isoxazolyl Biphenylsulfonamides with Improved Potency and Pharmacokinetics

2005 ◽  
Vol 48 (1) ◽  
pp. 171-179 ◽  
Author(s):  
Natesan Murugesan ◽  
Zhengxiang Gu ◽  
Leena Fadnis ◽  
John E. Tellew ◽  
Rose Ann F. Baska ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Receptor Antagonists ◽  
Endothelin A Receptor ◽  
Endothelin A
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