Synthesis of oligo-closo-dodecaborates by Hüisgen click reaction as encapsulated agents for the preparation of high-boron-content liposomes for neutron capture therapy

2015 ◽  
Vol 39 (8) ◽  
pp. 6388-6394 ◽  
Author(s):  
Hayato Koganei ◽  
Shoji Tachikawa ◽  
Mohamed E. El-Zaria ◽  
Hiroyuki Nakamura
Keyword(s):  
Neutron Capture ◽  
Boron Content ◽  
Click Reaction ◽  
Neutron Capture Therapy ◽  
High Boron

High boron-content molecules and their encapsulated liposomes.

Development of High Boron Content Liposomes and Their Promising Antitumor Effect for Neutron Capture Therapy of Cancers

2012 ◽  
Vol 24 (1) ◽  
pp. 124-132 ◽  
Author(s):  
Hayato Koganei ◽  
Manabu Ueno ◽  
Shoji Tachikawa ◽  
Lisa Tasaki ◽  
Hyun Seung Ban ◽  
...  
Keyword(s):  
Neutron Capture ◽  
Antitumor Effect ◽  
Boron Content ◽  
Neutron Capture Therapy ◽  
High Boron

scholarly journals Recent Advances in the Synthesis of High Boron-Loaded Nucleic Acids for BNCT

2021 ◽  
Vol 9 ◽  
Author(s):  
Darya Sergeevna Novopashina ◽  
Mariya Alexandrovna Vorobyeva ◽  
Alya Venyaminova
Keyword(s):  
Nucleic Acids ◽  
Boron Content ◽  
Neutron Capture Therapy ◽  
Boron Clusters ◽  
Boron Neutron Capture ◽  
High Boron ◽  
Low Toxicity ◽  
Therapeutic Tools ◽  
Phosphate Diesters ◽  
Oligonucleotide Conjugates

Boron clusters attract considerable attention as promising therapeutic tools for boron neutron capture therapy (BNCT). They combine high boron content with high chemical and biological stability, biorthogonality, and low toxicity. The development of oligonucleotide-based constructs and nucleic acid-like molecules, such as oligomeric phosphate diesters, bearing one or multiple boron clusters permits to create potential high boron-loaded agents for BNCT with good bioavailability, specifically interacting with nucleic acids inside the cell. Here, we shortly review the strategies and solutions in the design of oligonucleotide conjugates with boron clusters in light of the requirements for effective BNCT and future prospects of their practical use.

scholarly journals High Boron-loaded DNA-Oligomers as Potential Boron Neutron Capture Therapy and Antisense Oligonucleotide Dual-Action Anticancer Agents

Molecules ◽  
2017 ◽  
Vol 22 (9) ◽  
pp. 1393 ◽  
Author(s):  
Damian Kaniowski ◽  
Katarzyna Ebenryter-Olbińska ◽  
Milena Sobczak ◽  
Błażej Wojtczak ◽  
Sławomir Janczak ◽  
...  
Keyword(s):  
Anticancer Agents ◽  
Boron Neutron Capture Therapy ◽  
Neutron Capture ◽  
Antisense Oligonucleotide ◽  
Neutron Capture Therapy ◽  
Dna Oligomers ◽  
Boron Neutron Capture ◽  
Dual Action ◽  
High Boron

B-Decachloro-o-carborane Derivatives Suitable for the Preparation of Boron-Labeled Biological Macromolecules

1982 ◽  
Vol 37 (10) ◽  
pp. 1038-1039 ◽  
Author(s):  
Detlef Gabel ◽  
Rita Walczyna
Keyword(s):  
Concanavalin A ◽  
Neutron Capture ◽  
Boron Content ◽  
Water Soluble ◽  
Well Water ◽  
Neutron Capture Therapy ◽  
Biological Macromolecules ◽  
Human Igg ◽  
Alkaline Conditions

B-decachloro-o-carborane derivatives in which one of the carbon atoms was substituted by -CH2CH2CO2H (I), -CH2CHOHCH2-O-CH2CH=CH2 (II) and -CH2CHOHCH2-O-p-C6H4NHCOOC(CH3)3 (III) were prepared from decachloro-o-carborane and the corre­sponding bromo (I) or epoxi (II and III) derivatives under alkaline conditions. II could be epoxidized and bound to dextran, Concanavalin A, and human IgG, with a boron content of 4.3, 4.8. and 4.9% (w/w), respectively. III could be converted to the corresponding amine and further to the isothiocyanate. Such boron derivatives could be suitable compounds for neutron capture therapy of tumors, as they are well water soluble and could be attached to tumor spe­cific antibodies.

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