Design, synthesis and biological evaluation of novel podophyllotoxin derivatives bearing 4β-disulfide/trisulfide bond as cytotoxic agents

RSC Advances ◽  
2015 ◽  
Vol 5 (125) ◽  
pp. 103172-103183 ◽  
Author(s):  
Shi-Jun Zhu ◽  
Hua-Zhou Ying ◽  
Yan Wu ◽  
Ni Qiu ◽  
Tao Liu ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Cytotoxic Agents ◽  
Cytotoxic Activities ◽  
Kb Cells ◽  
Design Synthesis ◽  
Podophyllotoxin Derivatives ◽  
Synthesis And Biological Evaluation

A novel series of podophyllotoxin derivatives bearing 4β-disulfide/trisulfide were designed, synthesized and biologically evaluated for their cytotoxic activities against KB cells and KB/VCR cells.

Discovering Podophyllotoxin Derivatives as Potential Anti‐Tubulin Agents: Design, Synthesis and Biological Evaluation

2020 ◽  
Vol 5 (34) ◽  
pp. 10526-10536
Author(s):  
Hongwei Han ◽  
Xinhong Xu ◽  
Yingying Ma ◽  
Yuelin Luo ◽  
Zizhen Wang ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Design Synthesis ◽  
Podophyllotoxin Derivatives ◽  
Synthesis And Biological Evaluation

Design, synthesis, and biological evaluation of new series of 2-amido-1,3,4-thiadiazole derivatives as cytotoxic agents

2016 ◽  
Vol 71 (3) ◽  
pp. 205-210 ◽  
Author(s):  
Ali Almasirad ◽  
Loghman Firoozpour ◽  
Maliheh Nejati ◽  
Najmeh Edraki ◽  
Omidreza Firuzi ◽  
...  
Keyword(s):  
Human Tumor ◽  
Inhibitory Effect ◽  
Biological Evaluation ◽  
Cytotoxic Agents ◽  
Antitumor Activities ◽  
Design Synthesis ◽  
Ethidium Bromide Staining ◽  
Thiadiazole Derivatives ◽  
Synthesis And Biological Evaluation

AbstractA series of novel 1,3,4-thiadiazole derivatives bearing an amide moiety were designed, synthesized, and evaluated for their in vitro antitumor activities against HL-60, SKOV-3 and MOLT-4 human tumor cell lines by MTT assay. Ethyl 2-((5-(4-methoxybenzamido)-1,3,4-thiadiazol-2-yl)thio)acetate (5f) showed the best inhibitory effect against SKOV-3 cells, with an IC50 value of 19.5 μm. In addition, the acridine orange/ethidium bromide staining assay in SKOV-3 cells suggested that the cytotoxic activity of 5f occurs via apoptosis.

scholarly journals Design, synthesis and biological evaluation of novel nitric oxide-donating podophyllotoxin derivatives as potential antiproliferative agents against multi-drug resistant leukemia cells

RSC Advances ◽  
2018 ◽  
Vol 8 (60) ◽  
pp. 34266-34274 ◽  
Author(s):  
Lei Zhang ◽  
Ying Rong ◽  
Jie Zheng ◽  
Chengli Yang ◽  
Yongzheng Chen ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Antiproliferative Activity ◽  
Biological Evaluation ◽  
Leukemia Cells ◽  
Drug Resistant ◽  
Design Synthesis ◽  
Antiproliferative Agents ◽  
Podophyllotoxin Derivatives ◽  
Synthesis And Biological Evaluation

Conjugate S1 exhibited potential antiproliferative activity against multi-drug resistant leukemia cells.

scholarly journals Design, synthesis and biological evaluation of benzimidazole–rhodanine conjugates as potent topoisomerase II inhibitors

MedChemComm ◽  
2018 ◽  
Vol 9 (7) ◽  
pp. 1194-1205 ◽  
Author(s):  
Penghui Li ◽  
Wenjin Zhang ◽  
Hong Jiang ◽  
Yongliang Li ◽  
Changzhi Dong ◽  
...  
Keyword(s):  
Topoisomerase Ii ◽  
Biological Evaluation ◽  
Cytotoxic Activities ◽  
Design Synthesis ◽  
Topoisomerase Ii Inhibitors ◽  
Topo Ii ◽  
Synthesis And Biological Evaluation

In this study, a series of benzimidazole–rhodanine conjugates were designed, synthesized and investigated for their topoisomerase II (Topo II) inhibitory and cytotoxic activities.

Ethyl benzoate bearing pyrrolizine/indolizine moieties: Design, synthesis and biological evaluation of anti-inflammatory and cytotoxic activities

2020 ◽  
Vol 94 ◽  
pp. 103371 ◽  
Author(s):  
Khalid M. Attalah ◽  
Ashraf N. Abdalla ◽  
Akhmed Aslam ◽  
Muhammad Ahmed ◽  
Mohammed A.S. Abourehab ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Ethyl Benzoate ◽  
Cytotoxic Activities ◽  
Design Synthesis ◽  
Anti Inflammatory ◽  
Synthesis And Biological Evaluation
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