Discovering Podophyllotoxin Derivatives as Potential Anti‐Tubulin Agents: Design, Synthesis and Biological Evaluation

2020 ◽  
Vol 5 (34) ◽  
pp. 10526-10536
Author(s):  
Hongwei Han ◽  
Xinhong Xu ◽  
Yingying Ma ◽  
Yuelin Luo ◽  
Zizhen Wang ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Design Synthesis ◽  
Podophyllotoxin Derivatives ◽  
Synthesis And Biological Evaluation

scholarly journals Design, synthesis and biological evaluation of novel nitric oxide-donating podophyllotoxin derivatives as potential antiproliferative agents against multi-drug resistant leukemia cells

RSC Advances ◽  
2018 ◽  
Vol 8 (60) ◽  
pp. 34266-34274 ◽  
Author(s):  
Lei Zhang ◽  
Ying Rong ◽  
Jie Zheng ◽  
Chengli Yang ◽  
Yongzheng Chen ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Antiproliferative Activity ◽  
Biological Evaluation ◽  
Leukemia Cells ◽  
Drug Resistant ◽  
Design Synthesis ◽  
Antiproliferative Agents ◽  
Podophyllotoxin Derivatives ◽  
Synthesis And Biological Evaluation

Conjugate S1 exhibited potential antiproliferative activity against multi-drug resistant leukemia cells.

Design, synthesis and biological evaluation of novel podophyllotoxin derivatives bearing 4β-disulfide/trisulfide bond as cytotoxic agents

RSC Advances ◽  
2015 ◽  
Vol 5 (125) ◽  
pp. 103172-103183 ◽  
Author(s):  
Shi-Jun Zhu ◽  
Hua-Zhou Ying ◽  
Yan Wu ◽  
Ni Qiu ◽  
Tao Liu ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Cytotoxic Agents ◽  
Cytotoxic Activities ◽  
Kb Cells ◽  
Design Synthesis ◽  
Podophyllotoxin Derivatives ◽  
Synthesis And Biological Evaluation

A novel series of podophyllotoxin derivatives bearing 4β-disulfide/trisulfide were designed, synthesized and biologically evaluated for their cytotoxic activities against KB cells and KB/VCR cells.

Design, Synthesis and Biological Evaluation of Hybrid Molecules Containing Conjugated Styryl Ketone and α-Bromoacryloyl Moieties

2012 ◽  
Vol 9 (2) ◽  
pp. 140-152 ◽  
Author(s):  
Romeo Romagnoli ◽  
Pier Giovanni Baraldi ◽  
Olga Cruz-Lopez ◽  
Maria Kimatrai Salvador ◽  
Delia Preti ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Design Synthesis ◽  
Hybrid Molecules ◽  
Synthesis And Biological Evaluation

Design, Synthesis and Biological Evaluation of Novel Aminosaccharide Derivatives of Combretastatin A-4

2013 ◽  
Vol 10 (10) ◽  
pp. 935-941
Author(s):  
Yan Tang ◽  
Zhewei Tu ◽  
Jing Sun ◽  
Xiong Zhu ◽  
Kun Liu ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Design Synthesis ◽  
Synthesis And Biological Evaluation ◽  
Derivatives Of
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