Investigating the potential of human placenta-derived extracellular matrix sponges coupled with amniotic membrane-derived stem cells for osteochondral tissue engineering

2016 ◽  
Vol 4 (4) ◽  
pp. 613-625 ◽  
Author(s):  
Arun Prabhu Rameshbabu ◽  
Paulomi Ghosh ◽  
Elavarasan Subramani ◽  
Kamakshi Bankoti ◽  
Kausik Kapat ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Extracellular Matrix ◽  
Amniotic Membrane ◽  
Human Placenta ◽  
Osteochondral Defects ◽  
Osteochondral Tissue ◽  
Osteochondral Tissue Engineering

Placental extracellular matrix for osteochondral defects.

Stem Cells in Osteochondral Tissue Engineering

2018 ◽  
pp. 359-372 ◽  
Author(s):  
Eleonora Pintus ◽  
Matteo Baldassarri ◽  
Luca Perazzo ◽  
Simone Natali ◽  
Diego Ghinelli ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Osteochondral Tissue ◽  
Osteochondral Tissue Engineering

Regeneration of hyaline-like cartilage and subchondral bone simultaneously by poly(l-glutamic acid) based osteochondral scaffolds with induced autologous adipose derived stem cells

2016 ◽  
Vol 4 (15) ◽  
pp. 2628-2645 ◽  
Author(s):  
Kunxi Zhang ◽  
Shiming He ◽  
Shifeng Yan ◽  
Guifei Li ◽  
Danqing Zhang ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Glutamic Acid ◽  
Subchondral Bone ◽  
Hyaline Cartilage ◽  
Adipose Derived Stem Cells ◽  
Osteochondral Tissue ◽  
Osteochondral Tissue Engineering

Osteochondral tissue engineering is challenged by the difficulty in the regeneration of hyaline cartilage and the simultaneous regeneration of subchondral bone.

scholarly journals Multi-Layered Scaffolds for Osteochondral Tissue Engineering: In Vitro Response of Co-Cultured Human Mesenchymal Stem Cells

2015 ◽  
Vol 15 (11) ◽  
pp. 1535-1545 ◽  
Author(s):  
Sofia Amadori ◽  
Paola Torricelli ◽  
Silvia Panzavolta ◽  
Annapaola Parrilli ◽  
Milena Fini ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Human Mesenchymal Stem Cells ◽  
In Vitro Response ◽  
Osteochondral Tissue ◽  
Osteochondral Tissue Engineering

scholarly journals Cell Viability of Porous Poly(d,l-lactic acid)/Vertically Aligned Carbon Nanotubes/Nanohydroxyapatite Scaffolds for Osteochondral Tissue Engineering

Materials ◽  
2019 ◽  
Vol 12 (6) ◽  
pp. 849 ◽  
Author(s):  
Thiago Stocco ◽  
Eliane Antonioli ◽  
Conceição Elias ◽  
Bruno Rodrigues ◽  
Idália Siqueira ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Tissue Engineering ◽  
Lactic Acid ◽  
Type I ◽  
Osteochondral Defects ◽  
Vertically Aligned Carbon Nanotubes ◽  
Aligned Carbon Nanotubes ◽  
Vertically Aligned ◽  
Osteochondral Tissue ◽  
Osteochondral Tissue Engineering

Treatment of articular cartilage lesions remains an important challenge. Frequently the bone located below the cartilage is also damaged, resulting in defects known as osteochondral lesions. Tissue engineering has emerged as a potential approach to treat cartilage and osteochondral defects. The principal challenge of osteochondral tissue engineering is to create a scaffold with potential to regenerate both cartilage and the subchondral bone involved, considering the intrinsic properties of each tissue. Recent nanocomposites based on the incorporation of nanoscale fillers into polymer matrix have shown promising results for the treatment of osteochondral defects. In this present study, it was performed using the recently developed methodologies (electrodeposition and immersion in simulated body fluid) to obtain porous superhydrophilic poly(d,l-lactic acid)/vertically aligned carbon nanotubes/nanohydroxyapatite (PDLLA/VACNT-O:nHAp) nanocomposite scaffolds, to analyze cell behavior and gene expression of chondrocytes, and then assess the applicability of this nanobiomaterial for osteochondral regenerative medicine. The results demonstrate that PDLLA/VACNT-O:nHAp nanocomposite supports chondrocytes adhesion and decreases type I Collagen mRNA expression. Therefore, these findings suggest the possibility of novel nanobiomaterial as a scaffold for osteochondral tissue engineering applications.

scholarly journals Osteochondral tissue engineering: scaffolds, stem cells and applications

2012 ◽  
Vol 16 (10) ◽  
pp. 2247-2270 ◽  
Author(s):  
Patcharakamon Nooeaid ◽  
Vehid Salih ◽  
Justus P. Beier ◽  
Aldo R. Boccaccini
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Tissue Engineering Scaffolds ◽  
Osteochondral Tissue ◽  
Osteochondral Tissue Engineering
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