A water-soluble Pd(ii) complex with a terpyridine ligand: experimental and molecular modeling studies of the interaction with DNA and BSA; and in vitro cytotoxicity investigations against five human cancer cell lines

A new compound, namely hopane-6 α,16 α,22-triol (1), along with 8 known compounds 2 to 9, leucotylin (2), 16 β-acetoxyhopane-6 α,22-diol (3), 6 α-acetoxyhopane-16 β,22-diol (4), zeorin (5), 6 α-acetoxyhopane-22-ol (6), ergosterol peroxide (7), brassicasterol (8), and atranorin (9), was isolated from the lichen Parmotrema sancti-angelii. The structures of all the isolated compounds 1 to 9 were fully characterized using spectroscopic data, as well as comparison with the previous literature data. Moreover, compounds 2 and 4 were assessed for their in vitro cytotoxicity against 3 human cancer cell lines.

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Anticancer activity of newly synthesized 1,1‐disubstituted cyclohexane‐1‐carboxamides: in vitro caspases mediated apoptosis activators in human cancer cell lines and their molecular modeling

Drug Development Research ◽

10.1002/ddr.21573 ◽

2019 ◽

Vol 80 (7) ◽

pp. 933-947 ◽

Cited By ~ 1

Author(s):

Walaa Hamada Abd‐Allah ◽

Asmaa Salman ◽

Samah Sabry Saad

Keyword(s):

Molecular Modeling ◽

Anticancer Activity ◽

Cell Lines ◽

Cancer Cell ◽

Human Cancer ◽

Cancer Cell Lines ◽

Human Cancer Cell ◽

Human Cancer Cell Lines

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A New Non-glucosidic Iridoid from the Roots of Strychnos nux-blanda

Natural Product Communications ◽

10.1177/1934578x1601100602 ◽

2016 ◽

Vol 11 (6) ◽

pp. 1934578X1601100 ◽

Cited By ~ 1

Author(s):

Jirapast Sichaem ◽

Suttira Khumkratok ◽

Pongpun Siripong ◽

Santi Tip-pyang

Keyword(s):

Physical Properties ◽

Cell Lines ◽

Cancer Cell ◽

Human Cancer ◽

In Vitro Cytotoxicity ◽

Previous Literature ◽

Spectroscopic Methods ◽

Human Cancer Cell ◽

Human Cancer Cell Lines

Strychnuxin (1), a new non-glucosidic iridoid, together with four known compounds, IX (2), loganetin (3), loganin (4) and sweroside (5), were isolated from the roots of Strychnos nux-blanda. The structures of all isolated compounds (1-5) were elucidated through their physical properties and by the use of spectroscopic methods, as well as comparisons with the previous literature. To the best of our knowledge, this is the first isolation of compounds 1-5 from this plant. All isolated compounds were evaluated for their in vitro cytotoxicity against five human cancer cell lines.

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In vitro cytotoxicity against different human cancer cell lines of laticifer proteins of Calotropis procera (Ait.) R. Br

Toxicology in Vitro ◽

10.1016/j.tiv.2007.05.007 ◽

2007 ◽

Vol 21 (8) ◽

pp. 1563-1573 ◽

Cited By ~ 38

Author(s):

Jefferson Soares de Oliveira ◽

Daniel Pereira Bezerra ◽

Cleverson Diniz Teixeira de Freitas ◽

José Delano Barreto Marinho Filho ◽

Manoel Odorico de Moraes ◽

...

Keyword(s):

Cell Lines ◽

Cancer Cell ◽

Human Cancer ◽

Cancer Cell Lines ◽

In Vitro Cytotoxicity ◽

Calotropis Procera ◽

Human Cancer Cell ◽

Human Cancer Cell Lines

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Synthesis, characterisation and in vitro cytotoxicity of mixed ligand Pt(ii) oxadiazoline complexes with hexamethylenetetramine and 7-nitro-1,3,5-triazaadamantane

Dalton Transactions ◽

10.1039/c7dt02406a ◽

2017 ◽

Vol 46 (36) ◽

pp. 12226-12238 ◽

Cited By ~ 4

Author(s):

Stefanie Sieste ◽

Irina Lifincev ◽

Nina Stein ◽

Gabriele Wagner

Keyword(s):

Cell Lines ◽

Cancer Cell ◽

Human Cancer ◽

Cancer Cell Lines ◽

In Vitro Cytotoxicity ◽

Mixed Ligand ◽

Human Cancer Cell ◽

Human Cancer Cell Lines

The synthesis, spectroscopic and DFT-computational characterisation of trans-Pt(ii) oxadiazoline complexes is described. Some are more cytotoxic in vitro than cisplatin with the human cancer cell lines HeLa and A549.

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