Enantioselective conjugate addition of hydroxylamines to α,β-unsaturated 2-acyl imidazoles catalyzed by a chiral-at-metal Rh(iii) complex

2017 ◽  
Vol 4 (4) ◽  
pp. 573-577 ◽  
Author(s):  
Tao Deng ◽  
Ganesh Kumar Thota ◽  
Yi Li ◽  
Qiang Kang
Keyword(s):  
Amino Acid ◽  
Michael Addition ◽  
Conjugate Addition ◽  
Amino Acid Derivatives ◽  
Highly Efficient

A highly efficient chiral-at-metal Rh(iii) complex catalyzed asymmetric aza-Michael addition was developed, affordingN-protected β-amino acid derivatives with excellent enantioselectivity.

Highly Stereoselective Michael Addition Reactions of CamTHP*-Desymmetrized Glycinamide for the Synthesis of Functionally Dense Amino Acid Derivatives

2004 ◽  
Vol 6 (24) ◽  
pp. 4427-4429 ◽  
Author(s):  
Darren J. Dixon ◽  
Richard A. J. Horan ◽  
Nathaniel J. T. Monck ◽  
Paul Berg
Keyword(s):  
Amino Acid ◽  
Michael Addition ◽  
Amino Acid Derivatives ◽  
Addition Reactions

scholarly journals Substrate-controlled Diastereoselective Michael Addition of Alkylidene Malonates by Grignard Reagents

2019 ◽  
Vol 25 (1) ◽  
pp. 116-121
Author(s):  
Wei Zhou ◽  
Qingwei Xiao ◽  
Yuanyuan Chang ◽  
Qifa Liu ◽  
Xiaohao Zang ◽  
...  
Keyword(s):  
Amino Acid ◽  
Asymmetric Synthesis ◽  
Michael Addition ◽  
Chiral Auxiliary ◽  
Grignard Reagents ◽  
Amino Acid Derivatives ◽  
Catalyst Free ◽  
Chemical Efficiency

AbstractHerein is described a diastereoselective Michael addition of Grignard reagents to α, β- unsaturated diethyl malonates incorporated with a 2-oxazolidone chiral auxiliary. The catalyst-free Michael addition proceeds with good chemical efficiency and excellent stereoselectivity; and it provides new thoughts to the asymmetric synthesis of β-substituted β3 amino acid derivatives.

Cinchona alkaloid-based chiral catalysts act as highly efficient multifunctional organocatalysts for the asymmetric conjugate addition of malonates to nitroolefins

2015 ◽  
Vol 13 (40) ◽  
pp. 10216-10225 ◽  
Author(s):  
Veeramanoharan Ashokkumar ◽  
Ayyanar Siva
Keyword(s):  
Michael Addition ◽  
Quaternary Ammonium ◽  
Conjugate Addition ◽  
Quaternary Ammonium Salts ◽  
Cinchona Alkaloid ◽  
Ammonium Salts ◽  
Addition Reactions ◽  
Chiral Catalysts ◽  
Reaction Conditions ◽  
Highly Efficient

New pentaerythritol tetrabromide based chiral quaternary ammonium salts have been prepared and used as organocatalysts for enantioselective Michael addition reactions between various nitroolefins and Michael donors under mild reaction conditions with very good chemical yields and ee's.

Highly efficient and selective phosphorylation of amino acid derivatives and polyols catalysed by 2-aryl-4-(dimethylamino)pyridine-N-oxides – towards kinase-like reactivity

2014 ◽  
Vol 50 (88) ◽  
pp. 13608-13611 ◽  
Author(s):  
James I. Murray ◽  
Rudiger Woscholski ◽  
Alan C. Spivey
Keyword(s):  
Amino Acid ◽  
Amino Acid Derivatives ◽  
Highly Efficient

The chemoselective phosphorylation of hydroxyl containing amino acid derivatives and polyols by phosphoryl chlorides catalyzed by 2-aryl-4-(dimethylamino)pyridine-N-oxides is described.

ChemInform Abstract: Enantioselective Conjugate Addition of Oximes to Trisubstituted β-Nitroacrylates: An Organocatalytic Approach to β2,2-Amino Acid Derivatives.

ChemInform ◽  
2011 ◽  
Vol 42 (12) ◽  
pp. no-no
Author(s):  
Fu-Gen Zhang ◽  
Qing-Qing Yang ◽  
Jun Xuan ◽  
Hai-Hua Lu ◽  
Shu-Wen Duan ◽  
...  
Keyword(s):  
Amino Acid ◽  
Conjugate Addition ◽  
Amino Acid Derivatives

Straightforward synthesis of fluorinated amino acids by Michael addition of ethyl bromodifluoroacetate to α,β-unsaturated α-amino acid derivatives

2018 ◽  
Vol 211 ◽  
pp. 100-108 ◽  
Author(s):  
Ivan S. Kondratov ◽  
Maxym Ya. Bugera ◽  
Nataliya A. Tolmachova ◽  
Constantin G. Daniliuc ◽  
Günter Haufe
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Michael Addition ◽  
Amino Acid Derivatives ◽  
Fluorinated Amino Acids

scholarly journals Synthesis of bis-amino acid derivatives by Suzuki cross-coupling, Michael addition and substitution reactions

Amino Acids ◽  
2008 ◽  
Vol 36 (3) ◽  
pp. 429-436 ◽  
Author(s):  
P. M. T. Ferreira ◽  
L. S. Monteiro ◽  
M.-J. R. P. Queiroz ◽  
G. Pereira
Keyword(s):  
Amino Acid ◽  
Michael Addition ◽  
Cross Coupling ◽  
Amino Acid Derivatives ◽  
Substitution Reactions
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