Direct CuO nanoparticle-catalyzed synthesis of poly-substituted furans via oxidative C–H/C–H functionalization in aqueous medium

RSC Advances ◽  
2016 ◽  
Vol 6 (40) ◽  
pp. 33462-33467 ◽  
Author(s):  
Soumen Payra ◽  
Arijit Saha ◽  
Sandip Guchhait ◽  
Subhash Banerjee
Keyword(s):  
Aqueous Medium ◽  
Carbonyl Compounds ◽  
Aqueous Ethanol ◽  
Conjugate Addition ◽  
Cuo Nanoparticles ◽  
Domino Reactions ◽  
Furan Derivatives ◽  
Direct Functionalization ◽  
Substituted Furans ◽  
Cuo Nanoparticle

Here, we have reported CuO nanoparticles catalyzed synthesis of poly-functionalized furan derivatives via direct functionalization of α,β-unsaturated carbonyl compounds through conjugate addition initiated domino reactions in aqueous ethanol.

Pseudobase formation in 2-methylpapaverinium cations and their biotransformation by enzymes of rat liver homogenates in vitro

1980 ◽  
Vol 45 (3) ◽  
pp. 956-965 ◽  
Author(s):  
Daniela Walterová ◽  
Vladimír Preininger ◽  
Ladislav Dolejš ◽  
František Grambal ◽  
Miroslav Kyselý ◽  
...  
Keyword(s):  
Ionic Strength ◽  
Aqueous Medium ◽  
Rat Liver ◽  
Carbonyl Compounds ◽  
Liver Enzymes ◽  
Aqueous Ethanol ◽  
Equilibrium Constants ◽  
Liver Homogenates

2-Methylpapaverinium iodide (I), 2'-hydroxymethyl-2-methylpapaverinium iodide (IX), and 2-methyl-3,4-dihydropapaverinium iodide (X. CH3I) form pseudobase by addition of hydroxide ions to the C(1)=N(+) bond. 2'-Hydroxymethyl-2-methyl-3,4-dihydropapaverinium iodide (XV) and 2'-hydroxymethyl-2-methyl-9-oxo-3,4-dihydropapaverinium iodide (XVI) react with hydroxide ions in aqueous medium under formation of cyclic pseudobases XVII and XVIII. The equilibrium constants (KR+) of pseudobase formation have been measured in aqueous ethanol (1 : 1 w/w, 25°C, ionic strength 0.1). The quaternary papaverinium derivatives are metabolized to isoquinilones and carbonyl compounds by means of rat liver enzymes. The role of pseudobases in these biotransformations has been discussed and biogenetic conclusions have been drawn.

Conjugate addition of dimethylphenylsilyllithium to α,β-unsaturated carbonyl compounds mediated by sub-stoichiometric quantities of dimethylzinc

1997 ◽  
Vol 38 (42) ◽  
pp. 7313-7316 ◽  
Author(s):  
Bonnie L. MacLean ◽  
Kimberlea A. Hennigar ◽  
Kevin W. Kells ◽  
Robert D. Singer
Keyword(s):  
Carbonyl Compounds ◽  
Conjugate Addition
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