scholarly journals STAT3 inhibition suppresses hepatic stellate cell fibrogenesis: HJC0123, a potential therapeutic agent for liver fibrosis

RSC Advances ◽  
2016 ◽  
Vol 6 (102) ◽  
pp. 100652-100663 ◽  
Author(s):  
Omar Nunez Lopez ◽  
Fredrick J. Bohanon ◽  
Xiaofu Wang ◽  
Na Ye ◽  
Tiziana Corsello ◽  
...  
Keyword(s):  
Liver Fibrosis ◽  
Small Molecule ◽  
Hepatic Stellate Cell ◽  
Potential Role ◽  
Therapeutic Agent ◽  
Stellate Cell ◽  
The Novel ◽  
Potential Therapeutic Agent ◽  
Human Hscs ◽  
Stat3 Inhibition

The novel small molecule HJC0123 will inhibit STAT3 activation in human HSCs resulting in decreased fibrogenesis, unveiling a potential role for its use as a therapeutic agent for the treatment of liver fibrosis.

scholarly journals Induction of tropomyosin during hepatic stellate cell activation and the progression of liver fibrosis

2008 ◽  
Vol 3 (2) ◽  
pp. 378-383 ◽  
Author(s):  
Kohji Otogawa ◽  
Tomohiro Ogawa ◽  
Ryoko Shiga ◽  
Kazuo Ikeda ◽  
Norifumi Kawada
Keyword(s):  
Liver Fibrosis ◽  
Hepatic Stellate Cell ◽  
Cell Activation ◽  
Stellate Cell ◽  
Hepatic Stellate Cell Activation

Hepatic Stellate Cell as a Mac‐2‐binding Protein‐producing Cell in Patients with Liver Fibrosis

2021 ◽  
Author(s):  
Dolgormaa Gantumur ◽  
Norifumi Harimoto ◽  
Ryo Muranushi ◽  
Kouki Hoshino ◽  
Chingun Batbayar ◽  
...  
Keyword(s):  
Liver Fibrosis ◽  
Hepatic Stellate Cell ◽  
Stellate Cell ◽  
Binding Protein

scholarly journals Dominant-negative soluble PDGF-β receptor inhibits hepatic stellate cell activation and attenuates liver fibrosis

2004 ◽  
Vol 84 (6) ◽  
pp. 766-777 ◽  
Author(s):  
Erawan Borkham-Kamphorst ◽  
Jens Herrmann ◽  
Doris Stoll ◽  
Jens Treptau ◽  
Axel M Gressner ◽  
...  
Keyword(s):  
Liver Fibrosis ◽  
Hepatic Stellate Cell ◽  
Cell Activation ◽  
Stellate Cell ◽  
Dominant Negative ◽  
Hepatic Stellate Cell Activation ◽  
Β Receptor

scholarly journals GW501516-activated PPARβ/δ promotes liver fibrosis via p38-JNK MAPK-induced hepatic stellate cell proliferation

2012 ◽  
Vol 2 (1) ◽  
pp. 34 ◽  
Author(s):  
Radina Kostadinova ◽  
Alexandra Montagner ◽  
Erwan Gouranton ◽  
Sébastien Fleury ◽  
Hervé Guillou ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Liver Fibrosis ◽  
Hepatic Stellate Cell ◽  
Stellate Cell
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