Hepatic Stellate Cell as a Mac‐2‐binding Protein‐producing Cell in Patients with Liver Fibrosis

2021 ◽  
Author(s):  
Dolgormaa Gantumur ◽  
Norifumi Harimoto ◽  
Ryo Muranushi ◽  
Kouki Hoshino ◽  
Chingun Batbayar ◽  
...  
Keyword(s):  
Liver Fibrosis ◽  
Hepatic Stellate Cell ◽  
Stellate Cell ◽  
Binding Protein

scholarly journals Induction of tropomyosin during hepatic stellate cell activation and the progression of liver fibrosis

2008 ◽  
Vol 3 (2) ◽  
pp. 378-383 ◽  
Author(s):  
Kohji Otogawa ◽  
Tomohiro Ogawa ◽  
Ryoko Shiga ◽  
Kazuo Ikeda ◽  
Norifumi Kawada
Keyword(s):  
Liver Fibrosis ◽  
Hepatic Stellate Cell ◽  
Cell Activation ◽  
Stellate Cell ◽  
Hepatic Stellate Cell Activation

scholarly journals Lenvatinib prevents liver fibrosis by inhibiting hepatic stellate cell activation and sinusoidal capillarization in experimental liver fibrosis

2021 ◽  
Author(s):  
Hiroyuki Ogawa ◽  
Kosuke Kaji ◽  
Norihisa Nishimura ◽  
Hirotetsu Takagi ◽  
Koji Ishida ◽  
...  
Keyword(s):  
Liver Fibrosis ◽  
Hepatic Stellate Cell ◽  
Cell Activation ◽  
Stellate Cell ◽  
Hepatic Stellate Cell Activation ◽  
Experimental Liver

Physalin B attenuates liver fibrosis via suppressing LAP2α‐HDAC1 mediated deacetylation of GLI1 and hepatic stellate cell activation

2021 ◽  
Author(s):  
Xiaoyun Zhu ◽  
Shengtao Ye ◽  
Dongke Yu ◽  
Yanqiu Zhang ◽  
Jie Li ◽  
...  
Keyword(s):  
Liver Fibrosis ◽  
Hepatic Stellate Cell ◽  
Cell Activation ◽  
Stellate Cell ◽  
Hepatic Stellate Cell Activation

scholarly journals Dominant-negative soluble PDGF-β receptor inhibits hepatic stellate cell activation and attenuates liver fibrosis

2004 ◽  
Vol 84 (6) ◽  
pp. 766-777 ◽  
Author(s):  
Erawan Borkham-Kamphorst ◽  
Jens Herrmann ◽  
Doris Stoll ◽  
Jens Treptau ◽  
Axel M Gressner ◽  
...  
Keyword(s):  
Liver Fibrosis ◽  
Hepatic Stellate Cell ◽  
Cell Activation ◽  
Stellate Cell ◽  
Dominant Negative ◽  
Hepatic Stellate Cell Activation ◽  
Β Receptor

The Role of Matrix Stiffness in Hepatic Stellate Cell Activation and Liver Fibrosis

2005 ◽  
Vol 13 (1) ◽  
pp. A24-A24 ◽  
Author(s):  
MDA Gaca ◽  
PC Georges ◽  
JJ Hui ◽  
PA Janmey ◽  
RG Wells
Keyword(s):  
Liver Fibrosis ◽  
Hepatic Stellate Cell ◽  
Cell Activation ◽  
Stellate Cell ◽  
Matrix Stiffness ◽  
Hepatic Stellate Cell Activation

scholarly journals GW501516-activated PPARβ/δ promotes liver fibrosis via p38-JNK MAPK-induced hepatic stellate cell proliferation

2012 ◽  
Vol 2 (1) ◽  
pp. 34 ◽  
Author(s):  
Radina Kostadinova ◽  
Alexandra Montagner ◽  
Erwan Gouranton ◽  
Sébastien Fleury ◽  
Hervé Guillou ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Liver Fibrosis ◽  
Hepatic Stellate Cell ◽  
Stellate Cell

MicroRNA-195-3p promotes hepatic stellate cell activation and liver fibrosis by suppressing PTEN expression

2021 ◽  
Author(s):  
Ao Wang ◽  
Fang-tian Bu ◽  
Juan-juan Li ◽  
Ya-fei Zhang ◽  
Peng-cheng Jia ◽  
...  
Keyword(s):  
Liver Fibrosis ◽  
Hepatic Stellate Cell ◽  
Cell Activation ◽  
Stellate Cell ◽  
Pten Expression ◽  
Hepatic Stellate Cell Activation

Hepatic stellate cell-targeted imatinib nanomedicine versus conventional imatinib: A novel strategy with potent efficacy in experimental liver fibrosis

2017 ◽  
Vol 266 ◽  
pp. 226-237 ◽  
Author(s):  
Nesrine S. El-Mezayen ◽  
Wessam F. El-Hadidy ◽  
Wessam M. El-Refaie ◽  
Th.I. Shalaby ◽  
Mahmoud M. Khattab ◽  
...  
Keyword(s):  
Liver Fibrosis ◽  
Hepatic Stellate Cell ◽  
Stellate Cell ◽  
Novel Strategy ◽  
Experimental Liver

scholarly journals Identification of GDF15 as A Pro-Fibrotic Factor in Mouse Liver Fibrosis Progression

2021 ◽  
Author(s):  
Peng Qi ◽  
Ming-Ze Ma ◽  
Jing-Hua Kuai
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Fibrosis ◽  
Hepatic Stellate Cell ◽  
Hepatic Stellate Cells ◽  
Liver Tissue ◽  
Cell Activation ◽  
Stellate Cell ◽  
Neutralizing Antibody ◽  
Stellate Cells ◽  
Fibrosis Progression

Abstract Aim:To elucidate the inhibitory role of growth differentiation factor 15 (GDF15) in liver fibrosis and its possible activation mechanism in hepatic stellate cells of mice.Methods:We generated a GDF15-neutralizing antibody that can inhibit TGF-β1-induced activation of the TGF-β/Smad2/3 pathway in LX-2 cells. All the mice in this study were induced by carbon tetrachloride and thioacetamide. In addition, primary hepatic stellate cells from mice were isolated from fresh livers using Nycodenz density gradient separation. The severity and extent of liver fibrosis in mice were evaluated by Sirius Red and Masson staining. The effect of GDF15 on the activation of the TGF-β pathway was detected using dual-luciferase reporter assays and Western blotting assays.Results:The expression of GDF15 in cirrhotic liver tissue was higher than that in normal liver tissue. Blocking GDF15 with a neutralizing antibody resulted in a delay in primary hepatic stellate cell activation and remission of liver fibrosis induced by carbon tetrachloride or thioacetamide. Meanwhile, TGF-β pathway activation was partly inhibited by a GDF15-neutralizing antibody in primary hepatic stellate cells. These results indicated that GDF15 plays an important role in regulating HSC activation and liver fibrosis progression.Conclusions:The inhibition of GDF15 attenuates chemical-inducible liver fibrosis and delays hepatic stellate cell activation, and this effect is probably mainly attributed to its regulatory role in TGF-β signalling.

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