Merging gold catalysis, organocatalytic oxidation, and Lewis acid catalysis for chemodivergent synthesis of functionalized oxazoles from N-propargylamides

2017 ◽  
Vol 53 (75) ◽  
pp. 10366-10369 ◽  
Author(s):  
Shaoyu Mai ◽  
Changqing Rao ◽  
Ming Chen ◽  
Jihu Su ◽  
Jiangfeng Du ◽  
...  
Keyword(s):  
Transition Metal ◽  
Lewis Acid ◽  
Lewis Acids ◽  
Acid Catalysis ◽  
Gold Catalysis ◽  
One Pot ◽  
Catalytic Systems ◽  
One Pot Synthesis ◽  
The One ◽  
Cationic Gold

Novel catalytic systems consisting of cationic gold complexes, N-hydroxyphthalimide (NHPI), and transition-metal-based Lewis acids have been developed for the one-pot synthesis of functionalized oxazoles.

Direct Propargylation of ortho-Quinone Methides with Alkynyl Zinc Reagents: An Application to the One-Pot Synthesis of 2,3-Disubstituted Benzofurans

Synlett ◽  
2020 ◽  
Vol 31 (08) ◽  
pp. 818-822
Author(s):  
Hongjun Ren ◽  
Manman Sun ◽  
Jinyu Song ◽  
Lei Wang ◽  
Wenguang Yin ◽  
...  
Keyword(s):  
Transition Metal ◽  
Functional Group ◽  
Quinone Methides ◽  
One Pot ◽  
Metal Free ◽  
Efficient Strategy ◽  
One Pot Synthesis ◽  
Subsequent Cyclization ◽  
The One

A transition-metal-free propargylation of ortho-quinone methides (o-QMs) with alkynyl zinc reagents was achieved. A conjugate alkynylation of an o-QM and subsequent cyclization sequence in the presence of KOt-Bu for the synthesis of 2,3-disubstituted benzofurans in one pot was developed. This efficient strategy exhibits good functional-group compatibility and gives moderate to good yields. The present reaction might serve as an attractive method for the synthesis of polysubstituted benzofurans.

Lewis Acid–Doped Natural Phosphate: New Catalysts for the One‐Pot Synthesis of 3,4‐Dihydropyrimdin‐2(1H)‐one

2005 ◽  
Vol 35 (19) ◽  
pp. 2561-2568 ◽  
Author(s):  
Hanane El Badaoui ◽  
Fathallaah Bazi ◽  
Soumia Tamani ◽  
Saïd Boulaajaj ◽  
Mohamed Zahouily ◽  
...  
Keyword(s):  
Lewis Acid ◽  
One Pot ◽  
Natural Phosphate ◽  
One Pot Synthesis ◽  
The One

scholarly journals Lanthanide nitrates as Lewis acids in the one-pot synthesis of 1,2,4-oxadiazole derivatives

2012 ◽  
Vol 23 (8) ◽  
pp. 1437-1440 ◽  
Author(s):  
Juliana A. Vale ◽  
Wagner M. Faustino ◽  
Davila de S. Zampieri ◽  
Paulo J. S. Moran ◽  
José A. R. Rodrigues ◽  
...  
Keyword(s):  
Lewis Acids ◽  
One Pot ◽  
One Pot Synthesis ◽  
Oxadiazole Derivatives ◽  
Lanthanide Nitrates ◽  
The One

scholarly journals Enantioselective one-pot synthesis of dihydroquinolones via BINOL-derived Lewis acid catalysis

2014 ◽  
Vol 12 (28) ◽  
pp. 5094-5097 ◽  
Author(s):  
Peter C. Knipe ◽  
Martin D. Smith
Keyword(s):  
Lewis Acid ◽  
Acid Catalysis ◽  
Lewis Acid Catalysis ◽  
One Pot ◽  
One Pot Synthesis

A high-yielding and diastereoselective route to biologically significant 2-aryl- and 2-alkyl-3-amido dihydroquinolones has been developed in up to 90 : 10 e.r. by employing a novel Lewis acidic BINOL-derived copper(ii) catalyst.

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