scholarly journals Black pepper-based beverage induced appetite-suppressing effects without altering postprandial glycaemia, gut and thyroid hormones or gastrointestinal well-being: a randomized crossover study in healthy subjects

2018 ◽  
Vol 9 (5) ◽  
pp. 2774-2786 ◽  
Author(s):  
Yoghatama Cindya Zanzer ◽  
Merichel Plaza ◽  
Anestis Dougkas ◽  
Charlotta Turner ◽  
Elin Östman
Keyword(s):  
Glucose Metabolism ◽  
Thyroid Hormones ◽  
Crossover Study ◽  
Healthy Subjects ◽  
Clinical Investigation ◽  
Well Being ◽  
Black Pepper ◽  
Pleiotropic Effects ◽  
Energy Regulation ◽  
Randomized Crossover Study

Pleiotropic effects of spices on health, particularly on glucose metabolism and energy regulation, deserve further clinical investigation into their efficacy.

Single-Dose Comparative Pharmacokinetics of Two Formulations of Lenalidomide 25 mg in Healthy Subjects: A Randomized Crossover Study

2018 ◽  
Vol 35 (2) ◽  
pp. 210-217
Author(s):  
SeungHwan Lee ◽  
Jun Gi Hwang ◽  
Sang Yeob Park ◽  
Hye Jung Lim ◽  
Sa-Won Lee ◽  
...  
Keyword(s):  
Single Dose ◽  
Crossover Study ◽  
Healthy Subjects ◽  
Randomized Crossover Study

scholarly journals Erratum to: Tolerability of High-Volume Subcutaneous Injections of a Viscous Placebo Buffer: A Randomized, Crossover Study in Healthy Subjects

2015 ◽  
Vol 16 (6) ◽  
pp. 1500-1500 ◽  
Author(s):  
Clapton Dias ◽  
Bassam Abosaleem ◽  
Caroline Crispino ◽  
Bing Gao ◽  
Adam Shaywitz
Keyword(s):  
Crossover Study ◽  
Healthy Subjects ◽  
High Volume ◽  
Subcutaneous Injections ◽  
Randomized Crossover Study

scholarly journals Acute effects of three pulmonary reexpansion modalities on thoracoabdominal motion of healthy subjects: Randomized crossover study

PLoS ONE ◽  
2019 ◽  
Vol 14 (3) ◽  
pp. e0213773
Author(s):  
Rêncio Bento Florêncio ◽  
Andrea Aliverti ◽  
Marina Lyra Lima Cabral Fagundes ◽  
Ilsa Priscila dos Santos Batista ◽  
Antônio José Sarmento da Nóbrega ◽  
...  
Keyword(s):  
Crossover Study ◽  
Healthy Subjects ◽  
Acute Effects ◽  
Randomized Crossover Study

scholarly journals Effect of Grapefruit Juice on Clarithromycin Pharmacokinetics

1998 ◽  
Vol 42 (4) ◽  
pp. 927-929 ◽  
Author(s):  
Kit L. Cheng ◽  
Anne N. Nafziger ◽  
Charles A. Peloquin ◽  
Guy W. Amsden
Keyword(s):  
Crossover Study ◽  
Healthy Subjects ◽  
Peak Concentration ◽  
Grapefruit Juice ◽  
Pharmacokinetic Parameters ◽  
Time To Peak ◽  
Before And After ◽  
Randomized Crossover Study

ABSTRACT To investigate whether grapefruit juice inhibits the metabolism of clarithromycin, 12 healthy subjects were given water or grapefruit juice before and after a clarithromycin dose of 500 mg in a randomized crossover study. Administration of grapefruit juice increased the time to peak concentration of both clarithromycin (82 ± 35 versus 148 ± 83 min; P = 0.02) and 14-hydroxyclarithromycin (84 ± 38 min versus 173 ± 85;P = 0.01) but did not affect other pharmacokinetic parameters.

Effect of thyroid hormones on oxidative and nonoxidative glucose metabolism in humans

1988 ◽  
Vol 255 (2) ◽  
pp. E146-E152 ◽  
Author(s):  
M. J. Muller ◽  
K. J. Acheson ◽  
E. Jequier ◽  
A. G. Burger
Keyword(s):  
Glucose Metabolism ◽  
Thyroid Hormones ◽  
Lipid Oxidation ◽  
Healthy Subjects ◽  
Insulin Infusion ◽  
Glucose Disposal ◽  
Similar Extent ◽  
Before And After ◽  
Glucose Storage ◽  
Basal Energy Expenditure

The glucoregulatory function of thyroid hormones was investigated in six healthy subjects before and after 14 day 3,5,3',5'-tetraiodothyronine (T4) treatment (300 micrograms/day) using a sequential clamp protocol for 5 h at euglycemia (0–2 h) and hyperglycemia (165 mg/dl, 2–5 h) and different insulin infusion rates (1.0 for 0–3.5 h and 6.5 mU.kg-1.min-1, for 3.5–5 h). T4 treatment increased basal energy expenditure (+8%), glucose disposal (+31%), and oxidation (+87%) but decreased nonoxidative glucose metabolism (-30%) and was without effect on lipid oxidation. During the euglycemic clamp, T4 treatment enhanced insulin-induced glucose disposal (+16%), glucose oxidation (+34%), and inhibition of lipid oxidation (-66 vs. -40%); nonoxidative glucose metabolism was stimulated to a similar extent before and after T4. During hyperglycemia, 3,5,3'-triiodothyronine (T3) did not affect glucose disposal but increased carbohydrate-induced lipogenesis at both insulin infusion rates. We conclude that T4 treatment promotes glucose disposal and oxidation, T3 decreases noninsulin-mediated glucose storage but does not antagonize insulin action.

scholarly journals Tolerability of High-Volume Subcutaneous Injections of a Viscous Placebo Buffer: A Randomized, Crossover Study in Healthy Subjects

2015 ◽  
Vol 16 (5) ◽  
pp. 1101-1107 ◽  
Author(s):  
Clapton Dias ◽  
Bassam Abosaleem ◽  
Caroline Crispino ◽  
Bing Gao ◽  
Adam Shaywitz
Keyword(s):  
Crossover Study ◽  
Healthy Subjects ◽  
High Volume ◽  
Subcutaneous Injections ◽  
Randomized Crossover Study
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