A novel self-assembled pH-sensitive targeted nanoparticle platform based on antibody–4arm-polyethylene glycol–pterostilbene conjugates for co-delivery of anticancer drugs

2018 ◽  
Vol 6 (4) ◽  
pp. 656-665 ◽  
Author(s):  
Ke-Feng Liu ◽  
Yan-Xue Liu ◽  
Lin Dai ◽  
Chun-Xiao Li ◽  
Luying Wang ◽  
...  
Keyword(s):  
Polyethylene Glycol ◽  
Cancer Immunotherapy ◽  
Anticancer Drugs ◽  
Targeted Delivery ◽  
Ph Sensitive ◽  
Antibody Drug Conjugates ◽  
Drug Conjugates ◽  
Self Assembled ◽  
Antibody Drug

Recently, antibody–drug conjugates (ADC) have shown potential for cancer immunotherapy by tumor-targeted delivery of anticancer drugs.

Cancer-targeting Antibody–Drug Conjugates: Site-specific Conjugation of Doxorubicin to Anti-EGFR 528 Fab' through a Polyethylene Glycol Linker

2011 ◽  
Vol 64 (6) ◽  
pp. 779 ◽  
Author(s):  
Lisa P. T. Hong ◽  
Judith A. Scoble ◽  
Larissa Doughty ◽  
Gregory Coia ◽  
Charlotte C. Williams
Keyword(s):  
Polyethylene Glycol ◽  
Growth Factor Receptor ◽  
Antibody Fragment ◽  
Aqueous Solubility ◽  
Cancer Targeting ◽  
Antibody Activity ◽  
Antibody Drug Conjugates ◽  
Drug Conjugates ◽  
Epidermal Growth ◽  
Antibody Drug

Antibody–drug conjugates have been prepared to examine the effect that attaching small-molecule drugs to an antibody fragment has on antibody activity. The anticancer drug doxorubicin was covalently attached through a polyethylene glycol linker to a cancer-targeting, anti-epidermal growth factor receptor antibody fragment (Fab′). The reactivity of maleimide was compared with a substituted maleimide derivative (citraconimide) in conjugation reactions with cysteine residues on a Fab′. Introduction of polyethylene glycol increased aqueous solubility of the cytotoxic drug, which led to an improvement in overall yield of the conjugation reaction with the antibody fragment. Antibody–drug conjugates prepared retained activity of the parent antibody, as determined by antigen binding experiments measured by surface plasmon resonance.

scholarly journals Targeted Delivery of Cytotoxic NAMPT Inhibitors Using Antibody–Drug Conjugates

2018 ◽  
Vol 17 (12) ◽  
pp. 2633-2642 ◽  
Author(s):  
Christopher S. Neumann ◽  
Kathleen C. Olivas ◽  
Martha E. Anderson ◽  
Julia H. Cochran ◽  
Steven Jin ◽  
...  
Keyword(s):  
Targeted Delivery ◽  
Antibody Drug Conjugates ◽  
Drug Conjugates ◽  
Antibody Drug

The Methylene Alkoxy Carbamate Self-Immolative Unit: Utilization for the Targeted Delivery of Alcohol-Containing Payloads with Antibody-Drug Conjugates

2016 ◽  
Vol 128 (28) ◽  
pp. 8080-8083 ◽  
Author(s):  
Robert V. Kolakowski ◽  
Karl T. Haelsig ◽  
Kim K. Emmerton ◽  
Chris I. Leiske ◽  
Jamie B. Miyamoto ◽  
...  
Keyword(s):  
Targeted Delivery ◽  
Antibody Drug Conjugates ◽  
Drug Conjugates ◽  
Antibody Drug

Abstract 930: Targeted delivery of cytotoxic NAMPT inhibitors using antibody-drug conjugates

2018 ◽  
Author(s):  
Christopher S. Neumann ◽  
Kathleen C. Olivas ◽  
Andrew B. Waight ◽  
David Meyer ◽  
Luke V. Loftus ◽  
...  
Keyword(s):  
Targeted Delivery ◽  
Antibody Drug Conjugates ◽  
Drug Conjugates ◽  
Antibody Drug

Computationally designed antibody–drug conjugates self-assembled via affinity ligands

2019 ◽  
Vol 3 (11) ◽  
pp. 917-929 ◽  
Author(s):  
Nimish Gupta ◽  
Aasif Ansari ◽  
Gaurao V. Dhoke ◽  
Maheshwerreddy Chilamari ◽  
Jwala Sivaccumar ◽  
...  
Keyword(s):  
Affinity Ligands ◽  
Antibody Drug Conjugates ◽  
Drug Conjugates ◽  
Self Assembled ◽  
Antibody Drug

scholarly journals Author Correction: Computationally designed antibody–drug conjugates self-assembled via affinity ligands

2020 ◽  
Vol 4 (1) ◽  
pp. 131-131
Author(s):  
Nimish Gupta ◽  
Aasif Ansari ◽  
Gaurao V. Dhoke ◽  
Maheshwerreddy Chilamari ◽  
Jwala Sivaccumar ◽  
...  
Keyword(s):  
Affinity Ligands ◽  
Antibody Drug Conjugates ◽  
Drug Conjugates ◽  
Self Assembled ◽  
Antibody Drug

scholarly journals Considerations for the Nonclinical Safety Evaluation of Antibody–Drug Conjugates

Antibodies ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 15
Author(s):  
J. Edward Fisher
Keyword(s):  
Targeted Delivery ◽  
Safety Assessment ◽  
Adverse Reactions ◽  
Complex Molecule ◽  
Safety Evaluation ◽  
Clinical Development ◽  
Antibody Drug Conjugates ◽  
Drug Conjugates ◽  
Important Approach ◽  
Antibody Drug

The targeted delivery of drugs by means of linking them to antibodies (Abs) to form antibody–drug conjugates (ADCs) has become an important approach in oncology and could potentially be used in other therapeutic areas. Targeted therapy is aimed at improving clinical efficacy while minimizing adverse reactions. The nonclinical safety assessment of ADCs presents several unique challenges involving the need to examine a complex molecule, each component of which can contribute to the effects observed, in appropriate animal models. Some considerations for the nonclinical safety evaluation of ADCs based on a literature review of ADCs in clinical development (currently or previously) are discussed.

Sign in / Sign up

Export Citation Format

Share Document