Facile synthesis of 2,3-benzodiazepines using one-pot two-step phosphate-assisted acylation–hydrazine cyclization reactions

2018 ◽  
Vol 16 (21) ◽  
pp. 4013-4020 ◽  
Author(s):  
Akinari Sumita ◽  
Jinhee Lee ◽  
Yuko Otani ◽  
Tomohiko Ohwada
Keyword(s):  
Cyclization Reaction ◽  
Cyclization Reactions ◽  
Acylation Reaction ◽  
Facile Synthesis ◽  
One Pot

We present a one-pot two-step methodology, in which an unprotected amino is tolerated, for rapidly synthesizing 2,3-benzodiazepines via phosphate-assisted acylation reaction and hydrazine cyclization reaction.

Triamide macrocyclic chloride receptors via a one-pot tandem reduction–condensation–cyclization reaction

2017 ◽  
Vol 15 (23) ◽  
pp. 4937-4940 ◽  
Author(s):  
Harekrushna Behera ◽  
Venkatachalam Ramkumar ◽  
Nandita Madhavan
Keyword(s):  
Cyclization Reaction ◽  
Chloride Binding ◽  
Cyclization Reactions ◽  
One Pot

A chloride binding triamide macrocycle has been developed in one pot from the corresponding monomer via tandem reduction–condensation–cyclization reactions.

Synthesis of Pyrrolo[1,2-a][1,6]- and [1,8]naphthyridines by Alkyne-Carbonyl Metathesis

Synthesis ◽  
2020 ◽  
Author(s):  
Peter Ehlers ◽  
Peter Langer ◽  
Marian Blanco Ponce ◽  
Silvio Parpart ◽  
Alexander Villinger ◽  
...  
Keyword(s):  
Heterocyclic Compounds ◽  
Metathesis Reaction ◽  
Synthetic Methodology ◽  
Facile Synthesis ◽  
Reaction Conditions ◽  
One Pot ◽  
Metal Free ◽  
Modular Synthesis

AbstractA concise and modular synthesis of pyrrolo[1,2-a][1,6]- and [1,8]naphthyridines by a one-pot two-step reaction consisting of electrophilic acylation followed by an alkyne-carbonyl-metathesis reaction as the final cyclization step is reported. This developed synthetic methodology allows the facile synthesis of these heterocyclic core structures in mainly high overall yields under metal-free conditions. Reaction conditions are carefully optimized and display a novel supplement to access these tricyclic heterocyclic compounds.

Facile Synthesis of Nitrogen-Doped [(6.)m8]nCyclacene Carbon Nanobelts by a One-Pot Self-Condensation Reaction

2021 ◽  
Vol 143 (7) ◽  
pp. 2716-2721
Author(s):  
Jun Zhu ◽  
Yi Han ◽  
Yong Ni ◽  
Guangwu Li ◽  
Jishan Wu
Keyword(s):  
Condensation Reaction ◽  
Facile Synthesis ◽  
One Pot ◽  
Nitrogen Doped

ChemInform Abstract: Facile Synthesis of Multifunctional Pyrrole[2,1-a]isoquinolin-3(2H)-ones via Sulfa-Michael-Triggered One-Pot Reactions.

ChemInform ◽  
2016 ◽  
Vol 47 (25) ◽  
Author(s):  
Tian-You Qin ◽  
Lu Cheng ◽  
Ho-Chol Jang ◽  
Sean Xiao-An Zhang ◽  
Wei-Wei Liao
Keyword(s):  
Facile Synthesis ◽  
One Pot

One-Pot Synthesis of 1,2-Disubstituted 4-, 5-, 6-, and 7-Azaindoles from Amino-o-halopyridines via N-Arylation/Sonogashira/Cyclization Reaction

2017 ◽  
Vol 19 (19) ◽  
pp. 5118-5121 ◽  
Author(s):  
Sara I. Purificação ◽  
Marina J. D. Pires ◽  
Rafael Rippel ◽  
A. Sofia Santos ◽  
M. Manuel B. Marques
Keyword(s):  
Cyclization Reaction ◽  
One Pot ◽  
One Pot Synthesis

One-Pot Synthesis of Highly Substituted Allenylidene Derivatives via Palladium- or Nickel-Catalyzed Tandem Michael Addition-Cyclization Reaction

2009 ◽  
Vol 351 (1-2) ◽  
pp. 141-146 ◽  
Author(s):  
Yun Shi ◽  
Jing Huang ◽  
Yan-Fang Yang ◽  
Lu-Yong Wu ◽  
Yan-Ning Niu ◽  
...  
Keyword(s):  
Michael Addition ◽  
Cyclization Reaction ◽  
One Pot ◽  
One Pot Synthesis

Divergent synthesis of chiral heterocycles via sequencing of enantioselective three-component reactions and one-pot subsequent cyclization reactions

2015 ◽  
Vol 51 (53) ◽  
pp. 10612-10615 ◽  
Author(s):  
Min Tang ◽  
Dong Xing ◽  
Haoxi Huang ◽  
Wenhao Hu
Keyword(s):  
Cyclization Reactions ◽  
One Pot ◽  
Highly Efficient ◽  
Subsequent Cyclization

A highly efficient sequencing of enantioselective three-component reactions with a variety of one-pot subsequent cyclization reactions was developed.

ChemInform Abstract: Synthesis of [1,2,3]-Triazolo[1,5-a][1,4]benzodiazepines via an Unprecedented One-Pot Cu-Catalyzed Azidation-Cyclization Reaction.

ChemInform ◽  
2013 ◽  
Vol 44 (38) ◽  
pp. no-no
Author(s):  
Geert Hooyberghs ◽  
Hendrik De Coster ◽  
Dipak D. Vachhani ◽  
Denis S. Ermolat'ev ◽  
Erik V. Van der Eycken
Keyword(s):  
Cyclization Reaction ◽  
One Pot
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