Transition-metal-free cleavage of C–C double bonds: a three-component reaction of aromatic alkenes with S8and amides towards aryl thioamides

2018 ◽  
Vol 5 (22) ◽  
pp. 3315-3318 ◽  
Author(s):  
Lantao Liu ◽  
Zhanghong Guo ◽  
Kai Xu ◽  
Shuangshuang Hui ◽  
Xiaofang Zhao ◽  
...  
Keyword(s):  
Transition Metal ◽  
Double Bonds ◽  
Metal Free ◽  
Three Component Reaction

A novel transition-metal-free cleavage of C–C double bonds has been developed from a three-component reaction involving aromatic alkenes, S8and amides, generating various aryl thioamides in up to 96% yields.

Transition-metal-free three-component reaction of cyclopropenes, aldehydes and amines

2016 ◽  
Vol 52 (90) ◽  
pp. 13285-13287 ◽  
Author(s):  
Hang Zhang ◽  
Bo Wang ◽  
Heng Yi ◽  
Tong Sun ◽  
Yan Zhang ◽  
...  
Keyword(s):  
Transition Metal ◽  
Ring Opening ◽  
Metal Free ◽  
Three Component Reaction ◽  
Electron Withdrawing Substituents

A formal [3+2] cycloaddition triggered by enamine-mediated ring-opening of cyclopropenes bearing electron-withdrawing substituents is presented.

Transition-Metal-Free Three-Component Reaction: Additive Controlled Synthesis of Sulfonylated Imidazoles

2019 ◽  
Vol 84 (17) ◽  
pp. 11348-11358 ◽  
Author(s):  
Wei Liu ◽  
Yu Zhang ◽  
Jiaming He ◽  
Yue Yu ◽  
Jiajun Yuan ◽  
...  
Keyword(s):  
Transition Metal ◽  
Controlled Synthesis ◽  
Metal Free ◽  
Three Component Reaction

Direct synthesis of ortho-methylthio allyl and vinyl ethers via three component reaction of aryne, activated alkene and DMSO

2020 ◽  
Vol 18 (14) ◽  
pp. 2727-2738 ◽  
Author(s):  
Hemanta Hazarika ◽  
Pranjal Gogoi
Keyword(s):  
Transition Metal ◽  
Direct Synthesis ◽  
Vinyl Ethers ◽  
Metal Free ◽  
Synthetic Strategy ◽  
Three Component Reaction ◽  
Three Component Coupling

A transition-metal free synthetic strategy for the direct synthesis of ortho-methylthio allyl and vinyl ethers via cascade three-component coupling of aryne, activated alkene and DMSO.

Base-Catalyzed Tandem Cyclization: Diastereoselective Access to the 3,4-Dihydroisoquinolin-2(1H)-one Core

Synthesis ◽  
2018 ◽  
Vol 51 (06) ◽  
pp. 1473-1481 ◽  
Author(s):  
Harshadas Meshram ◽  
Ravindra Kumbhare ◽  
Prashishkumar Shirsat ◽  
Navnath Khomane ◽  
Sneha Meshram ◽  
...  
Keyword(s):  
Natural Products ◽  
Transition Metal ◽  
Acetylenic Esters ◽  
One Pot ◽  
Direct Construction ◽  
Metal Free ◽  
Diastereoselective Reaction ◽  
Three Component Reaction ◽  
Tandem Cyclization

A novel, one-pot reaction for the synthesis of 3,4-dihydroisoquinolin-2(1H)-one derivatives is developed via a base-mediated three-component reaction of ninhydrin, aniline and acetylenic esters. This diastereoselective reaction takes place in methanol at 70 °C under transition-metal-free conditions, and direct construction of the C–N and C–C bonds is readily achieved via tandem cyclization. These cyclic frameworks are resourceful small molecular keys to many natural products.

Transition-metal-free catalytic hydroboration reduction of amides to amines

2020 ◽  
Vol 7 (21) ◽  
pp. 3515-3520
Author(s):  
Wubing Yao ◽  
Jiali Wang ◽  
Aiguo Zhong ◽  
Shiliang Wang ◽  
Yinlin Shao
Keyword(s):  
Transition Metal ◽  
Selective Catalytic Reduction ◽  
Catalytic Reduction ◽  
Value Added ◽  
Metal Free

The selective catalytic reduction of amides to value-added amine products is a desirable but challenging transformation.

Deaminative carbonylative thioesterification of activated alkylamines with thiophenols under transition-metal-free conditions

2021 ◽  
Author(s):  
Fengqian Zhao ◽  
Xiao-Feng Wu
Keyword(s):  
Free Radical ◽  
Transition Metal ◽  
Metal Free

A transition-metal-free radical carbonylation of activated alkylamines with thiophenols has been successfully developed. Various thioesters were selectively produced with moderate to good yields.

Regioselective C3-H Trifluoromethylation of 2H-Indazole Under Transition-Metal-Free Photoredox Catalysis

2019 ◽  
Author(s):  
Arumugavel Murugan ◽  
Venkata Nagarjuna Babu ◽  
Nagaraj Sabarinathan ◽  
Sharada Duddu. S
Keyword(s):  
Transition Metal ◽  
Visible Light ◽  
Practical Approach ◽  
Hypervalent Iodine ◽  
Radical Mechanism ◽  
Photoredox Catalysis ◽  
Metal Free

Here we report a visible-light-promoted metal-free regioselective C3-H trifluoromehtylation reaction that proceeds via radical mechanism and which supported by control experiments. The combination of photoredox catalysis and hypervalent iodine reagent provides a practical approach for the present trifluoromethylation reaction and synthesis of a library of trifluoromethylated indazoles.

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