A DNA walker powered by endogenous enzymes for imaging uracil-DNA glycosylase activity in living cells

2019 ◽  
Vol 55 (43) ◽  
pp. 6026-6029 ◽  
Author(s):  
Xiaowen Xu ◽  
Pingping Zhang ◽  
Ruiyuan Zhang ◽  
Nan Zhang ◽  
Wei Jiang
Keyword(s):  
Living Cells ◽  
Dna Glycosylase ◽  
Uracil Dna Glycosylase ◽  
Dna Walker ◽  
Endogenous Enzymes

A DNA walker powered by endogenous enzymes detects uracil-DNA glycosylase activity in living cells.

scholarly journals Use of a molecular beacon based fluorescent method for assaying uracil DNA glycosylase (Ung) activity and inhibitor screening

2021 ◽  
Vol 26 ◽  
pp. 100954
Author(s):  
Avani Mehta ◽  
Prateek Raj ◽  
Sandeep Sundriyal ◽  
Balasubramanian Gopal ◽  
Umesh Varshney
Keyword(s):  
Molecular Beacon ◽  
Dna Glycosylase ◽  
Uracil Dna Glycosylase ◽  
Inhibitor Screening ◽  
Fluorescent Method

Crystal Structure of Family 5 Uracil-DNA Glycosylase Bound to DNA

2007 ◽  
Vol 373 (4) ◽  
pp. 839-850 ◽  
Author(s):  
Hiromichi Kosaka ◽  
Jun Hoseki ◽  
Noriko Nakagawa ◽  
Seiki Kuramitsu ◽  
Ryoji Masui
Keyword(s):  
Crystal Structure ◽  
Dna Glycosylase ◽  
Uracil Dna Glycosylase

Uracil-DNA Glycosylase Produces Excess Lethal Damage Induced by an Auger Cascade in BrdU-labelled Bacteriophage T1

1993 ◽  
Vol 64 (2) ◽  
pp. 157-164 ◽  
Author(s):  
Y. Furusawa ◽  
H. Maezawa ◽  
K. Suzuki ◽  
Y. Yamamoto ◽  
K. Kobayashi ◽  
...  
Keyword(s):  
Dna Glycosylase ◽  
Uracil Dna Glycosylase ◽  
Lethal Damage

A DNAzyme-driven random biped DNA walking nanomachine for ultrasensitive detection of UDG activity

The Analyst ◽  
2021 ◽  
Author(s):  
Li Tan ◽  
Jiangnan Lu ◽  
Xin Wang ◽  
Guang Liu ◽  
Xiaomei Mu ◽  
...  
Keyword(s):  
Medical Research ◽  
Dna Glycosylase ◽  
Ultrasensitive Detection ◽  
Genomic Integrity ◽  
Uracil Dna Glycosylase

Highly specific and ultrasensitive detection of Uracil-DNA glycosylase (UDG) activity is of great significance for maintaining genomic integrity and medical research of related diseases. Here, we constructed a random DNA...

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