A novel electrochemical immunosensor based on CoS2 for early screening of tumor marker carcinoembryonic antigen

2020 ◽  
Vol 44 (8) ◽  
pp. 3524-3532 ◽  
Author(s):  
Chulei Zhao ◽  
Chaoyun Ma ◽  
Mei Wu ◽  
Wenjun Li ◽  
Yiju Song ◽  
...  

In this work, PANI–HRP nanoparticles integrate biometric recognition and signal amplification functions in one body, which can be converted to each other without consuming the material itself.

The Analyst ◽  
2018 ◽  
Vol 143 (21) ◽  
pp. 5271-5277 ◽  
Author(s):  
Yu Jiang ◽  
Zhiying Su ◽  
Jian Zhang ◽  
Meijiao Cai ◽  
Lili Wu

A portable electrochemical immunosensor was designed for the detection of CEA on a pH meter by using glucose oxidase-encapsulated gold hollow microspheres for signal amplification.


Micromachines ◽  
2020 ◽  
Vol 11 (7) ◽  
pp. 660 ◽  
Author(s):  
Aihua Jing ◽  
Qiong Xu ◽  
Wenpo Feng ◽  
Gaofeng Liang

Carcinoembryonic antigen (CEA) is an important broad-spectrum tumor marker. The quantitative detection of a low concentration of CEA has important medical significance. In this study, three-dimensional porous graphene-oxide-supported platinum metal nanoparticles (3DPt/HGO) composites were prepared by a wet chemical method and modified on an electrode with enhanced conductivity, a large surface area, and good adsorption of immobilizing antibodies (Ab1). Horseradish peroxidase (HRP)-functionalized Au nanoparticles were fabricated to label the secondary antibodies (Ab2). The proposed immunosensor showed a good linear relationship in the range of 0.001–150 ng/mL for CEA and a detection limit of 0.0006 ng/mL. The immunosensor had high sensitivity, good stability and reproducibility, and has great application prospects for the clinical diagnosis of cancer.


2021 ◽  
Vol 613 ◽  
pp. 114017
Author(s):  
Maryam Jozghorbani ◽  
Mojtaba Fathi ◽  
Sayed Habib Kazemi ◽  
Navid Alinejadian

2021 ◽  
Author(s):  
Xiangrong Huang ◽  
Na Wu ◽  
Wenxiu Liu ◽  
Yazhuo Shang ◽  
Honglai Liu ◽  
...  

In this work, a novel redox hydrogel was proposed for ultrasensitive label-free electrochemical detection of carcinoembryonic antigen (CEA). The redox hydrogel composed by cellulose nanocrystalline (CNC), methylene blue (MB), multi-walled...


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