BPO-promoted direct oxidative C–H functionalization of unactivated alkanes into 6-alkyl-6H-benzo[c]chromenes under transition-metal-free conditions

A simple and efficient BPO-promoted free radical-based cascade reaction of biaryl vinyl ethers with easily available unactivated alkanes has been developed.

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A metal-free radical cascade reaction of phosphine oxides with 2-aryloxy phenylacetylenes to assemble diphosphonyl xanthene derivatives

Organic & Biomolecular Chemistry ◽

10.1039/d1ob01045j ◽

2021 ◽

Author(s):

Tao Fan ◽

Yan Liu ◽

Caina Jiang ◽

Yanli Xu ◽

Yan-Yan Chen

Keyword(s):

Free Radical ◽

Transition Metal ◽

Cascade Reaction ◽

Phosphine Oxides ◽

Metal Free ◽

Mild Conditions ◽

Xanthene Derivatives ◽

Reaction Proceeds ◽

Radical Cascade

A radical cascade reaction of 2-aryloxy phenylacetylene with phosphine oxides promoted by K2S2O8 was developed, provided diphosphonyl xanthenes as products. This reaction proceeds under transition metal-free and mild conditions with...

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Deaminative carbonylative thioesterification of activated alkylamines with thiophenols under transition-metal-free conditions

Organic Chemistry Frontiers ◽

10.1039/d0qo01479f ◽

2021 ◽

Author(s):

Fengqian Zhao ◽

Xiao-Feng Wu

Keyword(s):

Free Radical ◽

Transition Metal ◽

Metal Free

A transition-metal-free radical carbonylation of activated alkylamines with thiophenols has been successfully developed. Various thioesters were selectively produced with moderate to good yields.

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Transition-Metal-Free Radical C(sp3)–C(sp2) and C(sp3)–C(sp3) Coupling Enabled by 2-Azaallyls as Super-Electron-Donors and Coupling-Partners

Journal of the American Chemical Society ◽

10.1021/jacs.7b09394 ◽

2017 ◽

Vol 139 (45) ◽

pp. 16327-16333 ◽

Cited By ~ 35

Author(s):

Minyan Li ◽

Simon Berritt ◽

Lucas Matuszewski ◽

Guogang Deng ◽

Ana Pascual-Escudero ◽

...

Keyword(s):

Free Radical ◽

Transition Metal ◽

Electron Donors ◽

Metal Free

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A transition-metal-free multicomponent reaction towards constructing chiral 2H-1,4-benzoxazine scaffolds

Green Chemistry ◽

10.1039/d0gc02134b ◽

2020 ◽

Vol 22 (21) ◽

pp. 7506-7512

Author(s):

Lixiang Zhu ◽

Xiaoyu Ren ◽

Juan Du ◽

Jia-Hong Wu ◽

Jian-Ping Tan ◽

...

Keyword(s):

Transition Metal ◽

Multicomponent Reaction ◽

Phosphonium Salt ◽

Cascade Reaction ◽

Metal Free

A transition-metal-free multicomponent cascade reaction of α-halogenated ketones, ortho-aminophenols, and aldehydes using a dipeptide phosphonium salt catalyst was developed for the construction of various 2H-1,4-benzoxazines.

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Stereoselective three-component cascade synthesis of α-substituted 2,4-dienamides from gem-difluorochloro ethanes

Chemical Communications ◽

10.1039/c9cc07100h ◽

2019 ◽

Vol 55 (95) ◽

pp. 14355-14358

Author(s):

Shyamsundar Das ◽

Nakeun Ko ◽

Eunsung Lee ◽

Sang Eun Kim ◽

Byung Chul Lee

Keyword(s):

Transition Metal ◽

Claisen Rearrangement ◽

Cascade Reaction ◽

One Pot ◽

Metal Free

Herein, we describe a new transition metal-free Claisen rearrangement for the synthesis of α-substituted 2,4-dienamide. This one-pot, stereoselective three-component cascade reaction affords various polysubstituted 2,4-dienamides in good yields.

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One-pot transition-metal-free cascade synthesis of thieno[2,3-c]coumarins from chromones

RSC Advances ◽

10.1039/c6ra21776a ◽

2016 ◽

Vol 6 (106) ◽

pp. 103895-103898 ◽

Cited By ~ 3

Author(s):

Yuhong Yang ◽

Xueyu Qi ◽

Ruiling Liu ◽

Qian He ◽

Chunhao Yang

Keyword(s):

Transition Metal ◽

Cascade Reaction ◽

Free Base ◽

One Pot ◽

Metal Free

A one-pot transition-metal-free, base-mediated synthesis of a novel series of functionalized thieno[2,3-c]coumarins has been developed through a cascade reaction from chromones.

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