scholarly journals Switched reaction specificity in polyesterases towards amide bond hydrolysis by enzyme engineering

RSC Advances ◽  
2019 ◽  
Vol 9 (62) ◽  
pp. 36217-36226 ◽  
Author(s):  
Antonino Biundo ◽  
Raditya Subagia ◽  
Michael Maurer ◽  
Doris Ribitsch ◽  
Per-Olof Syrén ◽  
...  
Keyword(s):  
Enzyme Engineering ◽  
Amide Bond ◽  
Water Network ◽  
Nitrogen Inversion ◽  
Reaction Specificity ◽  
Inversion Mechanism

The constitution of a water network for the nitrogen inversion mechanism by H-bonding can increase amide-containing substrate acceptance of polyesterases.

scholarly journals Application of enzyme engineering in pharmacy

2020 ◽  
Vol 9 (2) ◽  
Author(s):  
Qiaole Li ◽  
Yanhong Li ◽  
Haoran Niu
Keyword(s):  
High Efficiency ◽  
Development Trend ◽  
Enzyme Engineering ◽  
Reaction Conditions ◽  
Important Method ◽  
Reaction Specificity ◽  
Prevention And Treatment ◽  
Modern Biotechnology ◽  
Catalytic Functions ◽  
The Development Trend

Enzyme engineering is an important part of modern biotechnology. Due to its high reaction specificity, high efficiency, mild reaction conditions, and low pollution, it is also an important method widely used in the pharmaceutical field. The application of enzymes in medicine is diverse, such as: diagnosis, prevention and treatment of diseases with enzymes, manufacture of various drugs with enzymes, etc., mainly through manual operations, to obtain enzymes required by the pharmaceutical industry, and through various means Enzymes perform their catalytic functions. This article mainly introduces the application of enzyme engineering in the pharmaceutical field, and also prospects the development trend of enzyme engineering in the pharmaceutical field.

scholarly journals Anandamide Hydrolysis in FAAH Reveals a Dual Strategy for Efficient Enzyme-Assisted Amide Bond Cleavage via Nitrogen Inversion

2014 ◽  
Vol 119 (3) ◽  
pp. 789-801 ◽  
Author(s):  
Giulia Palermo ◽  
Pablo Campomanes ◽  
Andrea Cavalli ◽  
Ursula Rothlisberger ◽  
Marco De Vivo
Keyword(s):  
Bond Cleavage ◽  
Amide Bond ◽  
Nitrogen Inversion ◽  
Amide Bond Cleavage ◽  
Dual Strategy

ChemInform Abstract: (E,Z)-Equilibria. Part 17. Demonstration of the Nitrogen Inversion Mechanism of Imines in a Schiff Base Model.

ChemInform ◽  
2010 ◽  
Vol 24 (27) ◽  
pp. no-no
Author(s):  
R. KNORR ◽  
J. RUHDORFER ◽  
J. MEHLSTAEUBL ◽  
P. BOEHRER ◽  
D. S. STEPHENSON
Keyword(s):  
Schiff Base ◽  
Nitrogen Inversion ◽  
Inversion Mechanism

(E, Z)1-Equilibria, 17 Demonstration of the Nitrogen Inversion Mechanism of Imines in a Schiff Base Model

1993 ◽  
Vol 126 (3) ◽  
pp. 747-754 ◽  
Author(s):  
Rudolf Knorr ◽  
Jakob Ruhdorfer ◽  
Johann Mehlstäubl ◽  
Petra Böhrer ◽  
David S. Stephenson
Keyword(s):  
Schiff Base ◽  
Nitrogen Inversion ◽  
Inversion Mechanism

Hindered rotation around the amide bond in a series of derivatives of 2-acetamidothiophenes

1991 ◽  
Vol 88 ◽  
pp. 689-707 ◽  
Author(s):  
P Andriamadio ◽  
D Nicole ◽  
A Cartier ◽  
M Wierzbicki ◽  
G Kirsch
Keyword(s):  
Amide Bond ◽  
Hindered Rotation ◽  
Derivatives Of
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