scholarly journals Phase I metabolic profiling and unexpected reactive metabolites in human liver microsome incubations of X-376 using LC-MS/MS: bioactivation pathway elucidation and in silico toxicity studies of its metabolites

RSC Advances ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. 5412-5427 ◽  
Author(s):  
Mohamed W. Attwa ◽  
Adnan A. Kadi ◽  
Ali S. Abdelhameed
Keyword(s):  
Phase I ◽  
Metabolic Profiling ◽  
In Silico ◽  
Human Liver ◽  
Liver Microsome ◽  
Human Liver Microsome ◽  
Reactive Metabolites ◽  
Toxicity Studies ◽  
Pyridazine Ring ◽  
In Silico Toxicity

Metabolites of X-376 were characterized by LC-MS/MS. Pyridazine ring and dichloro-phenyl groups were bioactivated by novel pathways.

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