Deaminative metal-free reaction of alkenylboronic acids, sodium metabisulfite and Katritzky salts

2021 ◽  
Author(s):  
Tonghao Zhu ◽  
Jia Shen ◽  
Yuyuan Sun ◽  
Jie Wu
Keyword(s):  
Sodium Metabisulfite ◽  
Metal Free ◽  
Efficient Approach ◽  
Three Component Reaction

A convenient and efficient approach to (E)-alkylsulfonyl olefins via a metal/light-free three-component reaction of alkenylboronic acids, sodium metabisulfite and Katritzky salts is described. This alkylsulfonylation proceeds smoothly with a broad substrate scope, leading to diverse (E)-alkylsulfonyl olefins in moderate to good yields.

Electrochemical Synthesis of Quinazolinones by the Metal-Free and Acceptor-Free Dehydrogenation of 2-Aminobenzamides

Synlett ◽  
2020 ◽  
Vol 31 (18) ◽  
pp. 1795-1799
Author(s):  
Qing-Hu Teng ◽  
Yan-Yan Chen ◽  
Yan Yao ◽  
Xiu-Jin Meng
Keyword(s):  
Electrochemical Synthesis ◽  
Metal Free ◽  
Efficient Approach

An efficient approach has been developed for the construction of quinazolin-4(3H)-ones by the selective anodic dehydrogenative oxidation/cyclization of benzylic chlorides and 2-aminobenzamides. The method features acceptor-free and metal-free dehydrogenation of amines to imines; a subsequent intermolecular addition provides the products in moderate to good yields.

Visible-light-promoted sulfonylation of thiols with aryldiazonium and sodium metabisulphite leading to unsymmetrical thiosulfonates

2021 ◽  
Author(s):  
Yu-Fen Lv ◽  
Jinyun Luo ◽  
Yuchuan Ma ◽  
Qi Dong ◽  
Lin He
Keyword(s):  
Visible Light ◽  
Room Temperature ◽  
Metal Free ◽  
Sodium Metabisulphite ◽  
Three Component Reaction

A new visible-light-mediated protocol has been proposed for the synthesis of thiosulfonates via metal-free sulfonylation of thiols with aryldiazonium and sodium metabisulphite at room temperature. This mild three-component reaction, simply...

Ketene Three-Component Reaction: A Metal-Free Multicomponent Approach to Stereodefined Captodative Olefins

2013 ◽  
Vol 52 (7) ◽  
pp. 2096-2099 ◽  
Author(s):  
Andrea Basso ◽  
Luca Banfi ◽  
Silvia Garbarino ◽  
Renata Riva
Keyword(s):  
Metal Free ◽  
Three Component Reaction

Three-component 3-(phosphoryl)methylindole synthesis from indoles, H-phosphine oxides and carbonyl compounds under metal-free conditions

2019 ◽  
Vol 21 (4) ◽  
pp. 792-797 ◽  
Author(s):  
Jiaoting Pan ◽  
Runmin Zhao ◽  
Jiami Guo ◽  
Dumei Ma ◽  
Ying Xia ◽  
...  
Keyword(s):  
Carbonyl Compounds ◽  
Indole Derivatives ◽  
Phosphine Oxides ◽  
One Pot ◽  
Metal Free ◽  
Three Component Reaction ◽  
Acid Catalyzed

The first facile and efficient acid-catalyzed three-component reaction of indoles, H-phosphine oxides and carbonyl compounds has been developed, providing a general, one-pot approach to structurally diverse C3-alkylated indole derivatives.

scholarly journals Efficient synthesis of pyrazolopyridines containing a chromane backbone through domino reaction

2019 ◽  
Vol 15 ◽  
pp. 874-880
Author(s):  
Razieh Navari ◽  
Saeed Balalaie ◽  
Saber Mehrparvar ◽  
Fatemeh Darvish ◽  
Frank Rominger ◽  
...  
Keyword(s):  
Room Temperature ◽  
High Selectivity ◽  
Domino Reaction ◽  
Primary Amines ◽  
Efficient Synthesis ◽  
Atom Economy ◽  
Reaction Conditions ◽  
Efficient Approach ◽  
Three Component Reaction ◽  
High Yields

An efficient approach for the synthesis of pyrazolopyridines containing the aminochromane motif through a base-catalyzed cyclization reaction is reported. The synthesis was carried out through a three-component reaction of (arylhydrazono)methyl-4H-chromen-4-one, malononitrile, primary amines in the presence of Et3N at room temperature. However, carrying out the reaction under the same conditions without base led to a fused chromanyl-cyanopyridine. High selectivity, high atom economy, and good to high yields in addition to mild reaction conditions are the advantages of this approach.

ChemInform Abstract: A Simple and Efficient Approach to the Synthesis of 4H-Furo[3,4-b]pyrans via a Three-Component Reaction of Isocyanides.

ChemInform ◽  
2008 ◽  
Vol 39 (48) ◽  
Author(s):  
Ahmad Shaabani ◽  
Ebrahim Soleimani ◽  
Afshin Sarvary ◽  
Ali Hossein Rezayan
Keyword(s):  
Efficient Approach ◽  
Three Component Reaction
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