scholarly journals A search for enhanced photodynamic activity against Staphylococcus aureus planktonic cells and biofilms: the evaluation of phthalocyanine–detonation nanodiamond–Ag nanoconjugates

2020 ◽  
Vol 19 (10) ◽  
pp. 1442-1454
Author(s):  
Yolande Ikala Openda ◽  
Refilwe Matshitse ◽  
Tebello Nyokong
Keyword(s):  
Staphylococcus Aureus ◽  
Antimicrobial Chemotherapy ◽  
Ag Nanoparticles ◽  
Detonation Nanodiamonds ◽  
Detonation Nanodiamond ◽  
Planktonic Cells ◽  
Photodynamic Antimicrobial Chemotherapy ◽  
Photodynamic Activity

Photodynamic antimicrobial chemotherapy (PACT) activity of phthalocyanines against planktonic cells and biofilms of S. aureus improved in the presence of detonation nanodiamonds, chitosan and Ag nanoparticles.

scholarly journals Photodynamic Antimicrobial Action of Asymmetrical Porphyrins Functionalized Silver-Detonation Nanodiamonds Nanoplatforms for the Suppression of Staphylococcus aureus Planktonic Cells and Biofilms

2021 ◽  
Vol 9 ◽  
Author(s):  
Yolande I. Openda ◽  
Bokolombe P. Ngoy ◽  
Tebello Nyokong
Keyword(s):  
Staphylococcus Aureus ◽  
Silver Nanoparticles ◽  
Quantum Yield ◽  
Antimicrobial Agent ◽  
Synergetic Effect ◽  
Detonation Nanodiamonds ◽  
Drug Resistant ◽  
Planktonic Cells ◽  
Photodynamic Antimicrobial Chemotherapy ◽  
Porphyrin Derivatives

New asymmetrical porphyrin derivatives containing a p-hydroxyphenyl moiety and p-acetylphenyl moieties along with their functionalized silver-detonation nanodiamonds nanohybrids were characterized and their photophysicochemical properties were established. The study provides evidence that the metalated porphyrin derivatives were red-shifted in absorption wavelength and possessed high singlet oxygen quantum yield comparative to the unmetalated core, thus making them suitable agents for photodynamic antimicrobial chemotherapy. As a result of conjugation to detonation nanodiamonds and silver nanoparticles, these compounds proved to be more effective as they exhibited stronger antibacterial and anti-biofilm activities on the multi-drug resistant S. aureus strain due to synergetic effect, compared to Ps alone. This suggests that the newly prepared nanohybrids could be used as a potential antimicrobial agent in the treatment of biofilms caused by S. aureus strain.

Photodynamic antimicrobial chemotherapy of asymmetric porphyrin-silver conjugates towards photoinactivation of Staphylococcus aureus

2020 ◽  
Vol 73 (4) ◽  
pp. 593-608 ◽  
Author(s):  
Samuel M. Shabangu ◽  
Balaji Babu ◽  
Rodah C. Soy ◽  
Muthumuni Managa ◽  
Kutloano E. Sekhosana ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Antimicrobial Chemotherapy ◽  
Photodynamic Antimicrobial Chemotherapy
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