Iridium-catalyzed stereoselective [3+2] annulation of α-oxocarboxylic acids with 1,3-dienes

2021 ◽  
Author(s):  
Ryota Yabe ◽  
Yusuke Ebe ◽  
Takahiro Nishimura
Keyword(s):  
Relative Stereochemistry ◽  
Oxocarboxylic Acids

Stereoselective annulation between α-oxocarboxoylic acids and 1,3-dienes proceeded in the presence of a hydroxoiridium catalyst to give α-hydroxy-γ-lactones in good yields with high 3,5-trans relative stereochemistry. The use of a...

The Merger of CF3SO2Na and Palladium Catalysis to Enable Decarboxylative Cross-Coupling for the Synthesis of Aromatic Ketones under Room Temperature

2021 ◽  
Author(s):  
Pan Xie ◽  
Cheng Xue ◽  
Cancan Wang ◽  
Dongdong Du ◽  
Sanshan Shi
Keyword(s):  
Visible Light ◽  
Room Temperature ◽  
Palladium Catalysis ◽  
Cross Coupling ◽  
Boronic Acids ◽  
Aromatic Ketones ◽  
Aryl Ketones ◽  
Oxocarboxylic Acids

A CF3SO2Na/Pd(OAc)2 co-catalyzed strategy is developed to produce aryl ketones via visible-light-induced decarboxylative cross-coupling of α-oxocarboxylic acids and aryl boronic acids. This process was perfomed under air at room temperature,...

α-Oxocarboxylic Acids as Three-Carbon Insertion Units for Palladium-Catalyzed Decarboxylative Cascade Synthesis of Diverse Fused Heteropolycycles

2021 ◽  
Vol 23 (8) ◽  
pp. 2878-2883
Author(s):  
Liwei Zhou ◽  
Shujia Qiao ◽  
Fengru Zhou ◽  
Xinyu Xuchen ◽  
Guobo Deng ◽  
...  
Keyword(s):  
Palladium Catalyzed ◽  
Oxocarboxylic Acids

Epimers l- and d-Phenylseptin: How the relative stereochemistry affects the peptide-membrane interactions

2021 ◽  
pp. 183708
Author(s):  
Victor H.O. Munhoz ◽  
Carolina S. Ferreira ◽  
Lucio O. Nunes ◽  
Talita L. Santos ◽  
Christopher Aisenbrey ◽  
...  
Keyword(s):  
Membrane Interactions ◽  
Relative Stereochemistry

Synthesis and Relative Stereochemistry of the A- and F-Rings of Goniodomin A.

ChemInform ◽  
2007 ◽  
Vol 38 (43) ◽  
Author(s):  
Kenshu Fujiwara ◽  
Jota Naka ◽  
Takahiro Katagiri ◽  
Daisuke Sato ◽  
Hidetoshi Kawai ◽  
...  
Keyword(s):  
Relative Stereochemistry

A New General Procedure for the Preparation of α-Oxocarboxylic Acids

Synthesis ◽  
1971 ◽  
Vol 1971 (10) ◽  
pp. 538-539 ◽  
Author(s):  
J. ANATOL ◽  
A. MEDÈTE
Keyword(s):  
General Procedure ◽  
Oxocarboxylic Acids

scholarly journals Asymmetric Synthesis of the C15–C32 Fragment of Alotamide and Determination of the Relative Stereochemistry

Marine Drugs ◽  
2018 ◽  
Vol 16 (11) ◽  
pp. 414 ◽  
Author(s):  
Hao-yun Shi ◽  
Yang Xie ◽  
Pei Hu ◽  
Zi-qiong Guo ◽  
Yi-hong Lu ◽  
...  
Keyword(s):  
Asymmetric Synthesis ◽  
Nmr Spectra ◽  
Calcium Influx ◽  
Aldol Reaction ◽  
13C Nmr Spectra ◽  
Marine Cyanobacterium ◽  
Relative Stereochemistry ◽  
Key Steps ◽  
Relative Structure

Alotamide is a cyclic depsipetide isolated from a marine cyanobacterium and possesses a unique activation of calcium influx in murine cerebrocortical neurons (EC50 4.18 µM). Due to its limited source, the three stereocenters (C19, C28, and C30) in its polyketide fragment remain undetermined. In this study, the first asymmetric synthesis of its polyketide fragment was achieved. Four relative possible diastereomers were constructed with a boron-mediated enantioselective aldol reaction and Julia–Kocienski olefination as the key steps. Comparison of 13C NMR spectra revealed the relative structure of fragment C15–C32 of alotamide.

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