Pd-catalysed general access to 7-membered N/O-heterocyclic compounds as potential agents against inflammation

2021 ◽  
Vol 57 (78) ◽  
pp. 10091-10094
Author(s):  
B. Thirupataiah ◽  
Gangireddy Sujeevan Reddy ◽  
Guntipally Mounika ◽  
Jetta Sandeep Kumar ◽  
Kazi Amirul Hossain ◽  
...  
Keyword(s):  
Heterocyclic Compounds ◽  
Bond Formation ◽  
Regioselective Synthesis

A Pd-catalysed regioselective synthesis of 4,5-disubstituted 7-membered N/O-heterocycles was achieved via the 7-endo-dig cyclization followed by C–C bond formation of 2-(1-alkynyl)phenylacetamide.

Iodine-mediated C–N and C–S bond formation: regioselective synthesis of benzo[4,5]imidazo[2,1-b]thiazoles

2017 ◽  
Vol 41 (1) ◽  
pp. 75-80 ◽  
Author(s):  
Sethurajan Ambethkar ◽  
Muthalu Vellimalai ◽  
Vediappen Padmini ◽  
Nattamai Bhuvanesh
Keyword(s):  
Reaction Time ◽  
Intramolecular Cyclization ◽  
Simple Procedure ◽  
Bond Formation ◽  
Molecular Iodine ◽  
Regioselective Synthesis ◽  
Thiazole Derivatives ◽  
Short Reaction Time ◽  
Metal Free

The regioselective synthesis of benzo[4,5]imidazo[2,1-b]thiazole derivatives via amination (C–N) and intramolecular cyclization (C–S) reactions in the presence of molecular iodine has been reported. This method is base and metal free and features inexpensive catalysts, with a simple procedure and a short reaction time.

Dioxygen-triggered oxidative cleavage of the C–S bond towards C–N bond formation

2019 ◽  
Vol 55 (82) ◽  
pp. 12332-12335 ◽  
Author(s):  
Zongchao Lv ◽  
Huamin Wang ◽  
Zhicong Quan ◽  
Yuan Gao ◽  
Aiwen Lei
Keyword(s):  
Heterocyclic Compounds ◽  
Bond Formation ◽  
Oxidative Cleavage

Dioxygen-triggered oxidative cleavage of C–S bonds has been achieved, delivering a series of N-containing heterocyclic compounds that are frequently found in pesticides and pharmaceuticals.

Recent Development in N-Auxilixary-Assisted Intramolecular Amination for Amine Substrates

Synlett ◽  
2015 ◽  
Vol 26 (08) ◽  
pp. 997-1002 ◽  
Author(s):  
Yingsheng Zhao ◽  
Chao Wang ◽  
Jian Han
Keyword(s):  
Transition Metal ◽  
Heterocyclic Compounds ◽  
Bond Formation ◽  
Direct Coupling ◽  
Significant Progress ◽  
Palladium Catalyzed ◽  
Directing Group

Direct coupling of N–H with C–H has aroused great attention in the last decades; during which the directing-group-assisted intramolecular C–N bond formation via transition metal has been achieved significant progress. Herein, we highlight the recent development in the directing-group-assisted intramolecular amination for amine substrates to build the important N-containing heterocyclic compounds.1 Introduction2 Triflamide-Promoted Intramolecular Amination3 Picolinamide-Assisted Intramolecular Amination4 Palladium-Catalyzed Intramolecular Amination under Assistance of Oxalyl Amide5 Conclusion

Reaction of 1,3-Bis(het)arylmonothio-1,3-diketones with Sodium Azide: Regioselective Synthesis of 3,5-Bis(het)arylisoxazoles via Intramolecular N–O Bond Formation

2020 ◽  
Vol 85 (23) ◽  
pp. 15422-15436
Author(s):  
Mary Antony P ◽  
Gantala L. Balaji ◽  
Pethaperumal Iniyavan ◽  
Hiriyakkanavar Ila
Keyword(s):  
Sodium Azide ◽  
Bond Formation ◽  
Regioselective Synthesis

Manganese(ii)-catalysed dehydrogenative annulation involving C–C bond formation: highly regioselective synthesis of quinolines

2019 ◽  
Vol 48 (14) ◽  
pp. 4474-4478 ◽  
Author(s):  
Chengniu Wang ◽  
Jinfei Yang ◽  
Xiao Meng ◽  
Yufeng Sun ◽  
Xuyan Man ◽  
...  
Keyword(s):  
Bond Formation ◽  
Regioselective Synthesis

An inexpensive nontoxic manganese(ii)-catalysed dehydrogenative annulation was developed for C–C bond formation.

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